In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from Human lymphomas

The CTLA4 receptor is a CD28 homologue which induces inhibitory effect on activated T‐cells. Peripheral T‐cells proliferate spontaneously in CTLA4‐deficient mice. These results led to an analysis of CTLA4 expression in human lymphomas (n=82) including Hodgkin's disease (HD) and non‐Hodgkin'...

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Veröffentlicht in:	The Journal of pathology 1997-10, Vol.183 (2), p.182-187
Hauptverfasser:	Xerri, Luc, Devilard, Elisabeth, Hassoun, Jacques, Olive, Daniel, Birg, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Antigens, CD - metabolism Antigens, Differentiation - metabolism Antigens, Neoplasm - metabolism B-Lymphocytes - immunology B7-1 Antigen - metabolism B7-2 Antigen Biological and medical sciences CD80 CD86 CTLA-4 Antigen CTLA4 Hematologic and hematopoietic diseases Hodgkin Disease - immunology Hodgkin's disease Humans Immunoconjugates Immunoenzyme Techniques Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - immunology Lymphoma, B-Cell - immunology Lymphoma, T-Cell - immunology Medical sciences Membrane Glycoproteins - metabolism non-Hodgkin's lymphoma T-Lymphocytes - immunology
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