Coronary Spasm: Clinical Features and Pathogenesis
Coronary artery spasm (coronary spasm) is an abnormal contraction of an epicardial coronary artery resulting in myocardial ischemia and its incidence is relatively high in Japanese as compared with Caucasians. Coronary spasm occurs most often from midnight to early morning when the patient is at res...
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| Veröffentlicht in: | Internal Medicine 1997, Vol.36(11), pp.760-765 |
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| container_title | Internal Medicine |
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| creator | YASUE, Hirofumi KUGIYAMA, Kiyotaka |
| description | Coronary artery spasm (coronary spasm) is an abnormal contraction of an epicardial coronary artery resulting in myocardial ischemia and its incidence is relatively high in Japanese as compared with Caucasians. Coronary spasm occurs most often from midnight to early morning when the patient is at rest and it is usually not induced by exercise in the daytime. Coronary spasm can be induced by acetylcholine, an endothelium-dependent vasodilator which causes vasodilatation in the normal coronary artery. Spasm artery is hyperresponsive to the vasodilator effect of nitroglycerin, an nitric oxide (NO) donor and is deficient in NO activity. The major risk factor for coronary spasm is cigarette smoking. Coronary spasm can be a cause of not only variant angina but also ischemic heart disease in general, including unstable angina, acute myocardial infarction and sudden ischemic death. (Internal Medicine 36: 760-765, 1997) |
| doi_str_mv | 10.2169/internalmedicine.36.760 |
| format | Article |
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Coronary spasm occurs most often from midnight to early morning when the patient is at rest and it is usually not induced by exercise in the daytime. Coronary spasm can be induced by acetylcholine, an endothelium-dependent vasodilator which causes vasodilatation in the normal coronary artery. Spasm artery is hyperresponsive to the vasodilator effect of nitroglycerin, an nitric oxide (NO) donor and is deficient in NO activity. The major risk factor for coronary spasm is cigarette smoking. Coronary spasm can be a cause of not only variant angina but also ischemic heart disease in general, including unstable angina, acute myocardial infarction and sudden ischemic death. (Internal Medicine 36: 760-765, 1997)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.36.760</identifier><identifier>PMID: 9392345</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>acetylcholine ; Acetylcholine - metabolism ; Autonomic Nervous System - metabolism ; Autonomic Nervous System - physiopathology ; Biological and medical sciences ; calcium antagonists ; Cardiology. Vascular system ; Circadian Rhythm ; Coronary Angiography ; Coronary heart disease ; Coronary Vasospasm - etiology ; Coronary Vasospasm - pathology ; Coronary Vasospasm - physiopathology ; Coronary Vessels - metabolism ; Coronary Vessels - pathology ; Electrocardiography ; endothelium ; Endothelium, Vascular - metabolism ; Heart ; Humans ; Hyperventilation - complications ; Hyperventilation - metabolism ; Medical sciences ; nitric oxide (NO) ; Nitric Oxide - metabolism ; Risk Factors ; variant angina ; Vasoconstriction</subject><ispartof>Internal Medicine, 1997, Vol.36(11), pp.760-765</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-c59b664a5ef2f0dd6a176cd3d2e90fb6a77384aa269a4b41972a455091095e8d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2104573$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9392345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YASUE, Hirofumi</creatorcontrib><creatorcontrib>KUGIYAMA, Kiyotaka</creatorcontrib><title>Coronary Spasm: Clinical Features and Pathogenesis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Coronary artery spasm (coronary spasm) is an abnormal contraction of an epicardial coronary artery resulting in myocardial ischemia and its incidence is relatively high in Japanese as compared with Caucasians. Coronary spasm occurs most often from midnight to early morning when the patient is at rest and it is usually not induced by exercise in the daytime. Coronary spasm can be induced by acetylcholine, an endothelium-dependent vasodilator which causes vasodilatation in the normal coronary artery. Spasm artery is hyperresponsive to the vasodilator effect of nitroglycerin, an nitric oxide (NO) donor and is deficient in NO activity. The major risk factor for coronary spasm is cigarette smoking. Coronary spasm can be a cause of not only variant angina but also ischemic heart disease in general, including unstable angina, acute myocardial infarction and sudden ischemic death. (Internal Medicine 36: 760-765, 1997)</description><subject>acetylcholine</subject><subject>Acetylcholine - metabolism</subject><subject>Autonomic Nervous System - metabolism</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Biological and medical sciences</subject><subject>calcium antagonists</subject><subject>Cardiology. Vascular system</subject><subject>Circadian Rhythm</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Coronary Vasospasm - etiology</subject><subject>Coronary Vasospasm - pathology</subject><subject>Coronary Vasospasm - physiopathology</subject><subject>Coronary Vessels - metabolism</subject><subject>Coronary Vessels - pathology</subject><subject>Electrocardiography</subject><subject>endothelium</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Heart</subject><subject>Humans</subject><subject>Hyperventilation - complications</subject><subject>Hyperventilation - metabolism</subject><subject>Medical sciences</subject><subject>nitric oxide (NO)</subject><subject>Nitric Oxide - metabolism</subject><subject>Risk Factors</subject><subject>variant angina</subject><subject>Vasoconstriction</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkElPwzAQhS0EgrL8BEQOiFuLt9gxN1SxSUgglrM1dSatUeoUOz3w73HVqAe4PB_eN543j5ALRiecKXPtQ48xQLvE2jsfcCLURCu6R0ZMSDPWXJT7ZEQNq8Y8yxE5TumLUlFpww_JoRGGC1mOCJ92sQsQf4r3FaTlTTFtffAO2uIeoV9HTAWEuniFftHNMWDy6ZQcNNAmPBveE_J5f_cxfRw_vzw8TW-fx66sZJ_VzJSSUGLDG1rXCphWrhY1R0ObmQKtRSUBuDIgZ5IZzUGWZY5MTYlVLU7I1fbfVey-15h6u_TJYdtCwG6drDZScl2JDOot6GKXUsTGrqJf5psso3bTlv3blhXK5rby5PmwYj3L3m5uqCf7l4MPKXfSRAjOpx3GGZWl3gR422JfqYc57nyIvXct_lvPjOGbCIwNmrPsYLeAaDGIX8QulL4</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>YASUE, Hirofumi</creator><creator>KUGIYAMA, Kiyotaka</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Coronary Spasm: Clinical Features and Pathogenesis</title><author>YASUE, Hirofumi ; KUGIYAMA, Kiyotaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-c59b664a5ef2f0dd6a176cd3d2e90fb6a77384aa269a4b41972a455091095e8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>acetylcholine</topic><topic>Acetylcholine - metabolism</topic><topic>Autonomic Nervous System - metabolism</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Biological and medical sciences</topic><topic>calcium antagonists</topic><topic>Cardiology. Vascular system</topic><topic>Circadian Rhythm</topic><topic>Coronary Angiography</topic><topic>Coronary heart disease</topic><topic>Coronary Vasospasm - etiology</topic><topic>Coronary Vasospasm - pathology</topic><topic>Coronary Vasospasm - physiopathology</topic><topic>Coronary Vessels - metabolism</topic><topic>Coronary Vessels - pathology</topic><topic>Electrocardiography</topic><topic>endothelium</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Heart</topic><topic>Humans</topic><topic>Hyperventilation - complications</topic><topic>Hyperventilation - metabolism</topic><topic>Medical sciences</topic><topic>nitric oxide (NO)</topic><topic>Nitric Oxide - metabolism</topic><topic>Risk Factors</topic><topic>variant angina</topic><topic>Vasoconstriction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YASUE, Hirofumi</creatorcontrib><creatorcontrib>KUGIYAMA, Kiyotaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YASUE, Hirofumi</au><au>KUGIYAMA, Kiyotaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary Spasm: Clinical Features and Pathogenesis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| fulltext | fulltext |
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| ispartof | Internal Medicine, 1997, Vol.36(11), pp.760-765 |
| issn | 0918-2918 1349-7235 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | acetylcholine Acetylcholine - metabolism Autonomic Nervous System - metabolism Autonomic Nervous System - physiopathology Biological and medical sciences calcium antagonists Cardiology. Vascular system Circadian Rhythm Coronary Angiography Coronary heart disease Coronary Vasospasm - etiology Coronary Vasospasm - pathology Coronary Vasospasm - physiopathology Coronary Vessels - metabolism Coronary Vessels - pathology Electrocardiography endothelium Endothelium, Vascular - metabolism Heart Humans Hyperventilation - complications Hyperventilation - metabolism Medical sciences nitric oxide (NO) Nitric Oxide - metabolism Risk Factors variant angina Vasoconstriction |
| title | Coronary Spasm: Clinical Features and Pathogenesis |
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