Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function
Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting re...
Gespeichert in:
| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 1989-11, Vol.13 (6), p.620-622 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 622 |
|---|---|
| container_issue | 6 |
| container_start_page | 620 |
| container_title | JPEN. Journal of parenteral and enteral nutrition |
| container_volume | 13 |
| creator | Herson, Victor C. Block, Charlotte Eisenfeld, Leonard Maderazo, Eufronio G. Krause, Peter J. |
| description | Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting results exist. In order to examine potential adverse hematologic effects of Intralipid, 10 ill neonates were studied before and after a 16-hr infusion of 1 g/kilo of Intralipid. PMN count, chemokinesis, chemotaxis, and aggregation were unchanged pre- and post intralipid infusion. Platelet count, bleeding time, and platelet aggregation were also unchanged. Similar results were obtained in vitro when neonatal and adult PMNs and platelets were incubated in Intralipid and their function analyzed. These findings suggest that short-term, low-dose Intralipid has no measurable impact on neonatal PMN or platelet activity and support its use in neonates even in the presence of infection or thrombocytopenia. (Journal of Parenteral and Enteral Nutrition
13:620-622, 1989) |
| doi_str_mv | 10.1177/0148607189013006620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79442420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0148607189013006620</sage_id><sourcerecordid>79442420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4210-eb76fead6d4c126746269a1edd1b59eca242b106c33ecdef8a8428d0a55613953</originalsourceid><addsrcrecordid>eNqNkEFr3DAQhUVoSLZpf0EJ-NLe3I5kWbaOJey2KSHZQ3I2s_IoddDKW0lOyb-vFi_NJYSAYCTme08zj7FPHL5y3jTfgMtWQcNbDbwCUErAEVtwLXkppJTv2GJPlHvklL2P8QEAKgVwwk5EzesK9IKtl9aSSbEYbXHpU8BH8uMUixWm_LZTHEZf5HNNo8eELl-mFMbd78EV6Pti7TCRo1SsJm9Shj-wY4su0sdDPWN3q-Xtxc_y6ubH5cX3q9JIwaGkTaMsYa96abhQjVRCaeTU93xTazIopNhwUKaqyPRkW2ylaHvAula80nV1xr7Mvrsw_pkopm47REPOoae8QNdoKbMHZLCaQRPGGAPZbheGLYanjkO3z7F7IcesOj_YT5st9f81h-By__Ohj9GgswG9GeKztVbZCVTm9Mz9HRw9veXr7td6eQ3zDDBrI95T9zBOwedEXx37HwqQl1U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79442420</pqid></control><display><type>article</type><title>Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Herson, Victor C. ; Block, Charlotte ; Eisenfeld, Leonard ; Maderazo, Eufronio G. ; Krause, Peter J.</creator><creatorcontrib>Herson, Victor C. ; Block, Charlotte ; Eisenfeld, Leonard ; Maderazo, Eufronio G. ; Krause, Peter J.</creatorcontrib><description>Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting results exist. In order to examine potential adverse hematologic effects of Intralipid, 10 ill neonates were studied before and after a 16-hr infusion of 1 g/kilo of Intralipid. PMN count, chemokinesis, chemotaxis, and aggregation were unchanged pre- and post intralipid infusion. Platelet count, bleeding time, and platelet aggregation were also unchanged. Similar results were obtained in vitro when neonatal and adult PMNs and platelets were incubated in Intralipid and their function analyzed. These findings suggest that short-term, low-dose Intralipid has no measurable impact on neonatal PMN or platelet activity and support its use in neonates even in the presence of infection or thrombocytopenia. (Journal of Parenteral and Enteral Nutrition
13:620-622, 1989)</description><identifier>ISSN: 0148-6071</identifier><identifier>EISSN: 1941-2444</identifier><identifier>DOI: 10.1177/0148607189013006620</identifier><identifier>PMID: 2515309</identifier><identifier>CODEN: JPENDU</identifier><language>eng</language><publisher>Thousand Oaks, CA: Sage Publications</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Platelets - metabolism ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Fat Emulsions, Intravenous - pharmacology ; Humans ; In Vitro Techniques ; Infant, Newborn ; Intensive care medicine ; Medical sciences ; Neutrophils - metabolism ; Parenteral Nutrition, Total</subject><ispartof>JPEN. Journal of parenteral and enteral nutrition, 1989-11, Vol.13 (6), p.620-622</ispartof><rights>1989 by The American Society for Parenteral and Enteral Nutrition</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4210-eb76fead6d4c126746269a1edd1b59eca242b106c33ecdef8a8428d0a55613953</citedby><cites>FETCH-LOGICAL-c4210-eb76fead6d4c126746269a1edd1b59eca242b106c33ecdef8a8428d0a55613953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F0148607189013006620$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F0148607189013006620$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19630006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2515309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herson, Victor C.</creatorcontrib><creatorcontrib>Block, Charlotte</creatorcontrib><creatorcontrib>Eisenfeld, Leonard</creatorcontrib><creatorcontrib>Maderazo, Eufronio G.</creatorcontrib><creatorcontrib>Krause, Peter J.</creatorcontrib><title>Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function</title><title>JPEN. Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting results exist. In order to examine potential adverse hematologic effects of Intralipid, 10 ill neonates were studied before and after a 16-hr infusion of 1 g/kilo of Intralipid. PMN count, chemokinesis, chemotaxis, and aggregation were unchanged pre- and post intralipid infusion. Platelet count, bleeding time, and platelet aggregation were also unchanged. Similar results were obtained in vitro when neonatal and adult PMNs and platelets were incubated in Intralipid and their function analyzed. These findings suggest that short-term, low-dose Intralipid has no measurable impact on neonatal PMN or platelet activity and support its use in neonates even in the presence of infection or thrombocytopenia. (Journal of Parenteral and Enteral Nutrition
13:620-622, 1989)</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Fat Emulsions, Intravenous - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Neutrophils - metabolism</subject><subject>Parenteral Nutrition, Total</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFr3DAQhUVoSLZpf0EJ-NLe3I5kWbaOJey2KSHZQ3I2s_IoddDKW0lOyb-vFi_NJYSAYCTme08zj7FPHL5y3jTfgMtWQcNbDbwCUErAEVtwLXkppJTv2GJPlHvklL2P8QEAKgVwwk5EzesK9IKtl9aSSbEYbXHpU8BH8uMUixWm_LZTHEZf5HNNo8eELl-mFMbd78EV6Pti7TCRo1SsJm9Shj-wY4su0sdDPWN3q-Xtxc_y6ubH5cX3q9JIwaGkTaMsYa96abhQjVRCaeTU93xTazIopNhwUKaqyPRkW2ylaHvAula80nV1xr7Mvrsw_pkopm47REPOoae8QNdoKbMHZLCaQRPGGAPZbheGLYanjkO3z7F7IcesOj_YT5st9f81h-By__Ohj9GgswG9GeKztVbZCVTm9Mz9HRw9veXr7td6eQ3zDDBrI95T9zBOwedEXx37HwqQl1U</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>Herson, Victor C.</creator><creator>Block, Charlotte</creator><creator>Eisenfeld, Leonard</creator><creator>Maderazo, Eufronio G.</creator><creator>Krause, Peter J.</creator><general>Sage Publications</general><general>SAGE Publications</general><general>ASPEN</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198911</creationdate><title>Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function</title><author>Herson, Victor C. ; Block, Charlotte ; Eisenfeld, Leonard ; Maderazo, Eufronio G. ; Krause, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4210-eb76fead6d4c126746269a1edd1b59eca242b106c33ecdef8a8428d0a55613953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Fat Emulsions, Intravenous - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Neutrophils - metabolism</topic><topic>Parenteral Nutrition, Total</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herson, Victor C.</creatorcontrib><creatorcontrib>Block, Charlotte</creatorcontrib><creatorcontrib>Eisenfeld, Leonard</creatorcontrib><creatorcontrib>Maderazo, Eufronio G.</creatorcontrib><creatorcontrib>Krause, Peter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herson, Victor C.</au><au>Block, Charlotte</au><au>Eisenfeld, Leonard</au><au>Maderazo, Eufronio G.</au><au>Krause, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>1989-11</date><risdate>1989</risdate><volume>13</volume><issue>6</issue><spage>620</spage><epage>622</epage><pages>620-622</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><coden>JPENDU</coden><abstract>Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting results exist. In order to examine potential adverse hematologic effects of Intralipid, 10 ill neonates were studied before and after a 16-hr infusion of 1 g/kilo of Intralipid. PMN count, chemokinesis, chemotaxis, and aggregation were unchanged pre- and post intralipid infusion. Platelet count, bleeding time, and platelet aggregation were also unchanged. Similar results were obtained in vitro when neonatal and adult PMNs and platelets were incubated in Intralipid and their function analyzed. These findings suggest that short-term, low-dose Intralipid has no measurable impact on neonatal PMN or platelet activity and support its use in neonates even in the presence of infection or thrombocytopenia. (Journal of Parenteral and Enteral Nutrition
13:620-622, 1989)</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>2515309</pmid><doi>10.1177/0148607189013006620</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-6071 |
| ispartof | JPEN. Journal of parenteral and enteral nutrition, 1989-11, Vol.13 (6), p.620-622 |
| issn | 0148-6071 1941-2444 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79442420 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Platelets - metabolism Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Fat Emulsions, Intravenous - pharmacology Humans In Vitro Techniques Infant, Newborn Intensive care medicine Medical sciences Neutrophils - metabolism Parenteral Nutrition, Total |
| title | Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A34%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Intravenous%20Fat%20Infusion%20on%20Neonatal%20Neutrophil%20and%20Platelet%20Function&rft.jtitle=JPEN.%20Journal%20of%20parenteral%20and%20enteral%20nutrition&rft.au=Herson,%20Victor%20C.&rft.date=1989-11&rft.volume=13&rft.issue=6&rft.spage=620&rft.epage=622&rft.pages=620-622&rft.issn=0148-6071&rft.eissn=1941-2444&rft.coden=JPENDU&rft_id=info:doi/10.1177/0148607189013006620&rft_dat=%3Cproquest_cross%3E79442420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79442420&rft_id=info:pmid/2515309&rft_sage_id=10.1177_0148607189013006620&rfr_iscdi=true |