Lymphocytic progesterone receptors in normal and pathological human pregnancy
The progesterone receptor-specific monoclonal antibody (MoAb) mPRI was tested for its reactivity towards peripheral blood lymphocytes (PBL) of 49 healthy pregnant women, nine pregnant women with clinical symptoms of threatened preterm delivery, seven women with recurrent spontaneous abortion, ten wo...
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| Veröffentlicht in: | Journal of reproductive immunology 1989-12, Vol.16 (3), p.239-247 |
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| container_title | Journal of reproductive immunology |
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| creator | Szekeres-Bartho, Julia Reznikoff-Etievant, M.F. Varga, P. Pichon, M.-F. Varga, Z. Chaouat, G. |
| description | The progesterone receptor-specific monoclonal antibody (MoAb) mPRI was tested for its reactivity towards peripheral blood lymphocytes (PBL) of 49 healthy pregnant women, nine pregnant women with clinical symptoms of threatened preterm delivery, seven women with recurrent spontaneous abortion, ten women in labour and ten women with spontaneous abortion. Lymphocytes of 12 healthy age-matched non-pregnant volunteers were used as controls. Lymphocytes of nine healthy pregnant women at the 1st trimester of pregnancy and those of two non-pregnant donors were tested for the presence of estrogen and progesterone receptors by enzyme immunoassay.
PBL of healthy pregnant women contained significantly more positive cells than those of non-pregnant controls. Furthermore, the number of receptor-containing cells increased in parallel with gestational age. In blood samples drawn during labour, as well as in those obtained from women with spontaneous abortion or clinical symptoms of threatened pre-term delivery, the percentage of positively stained lymphocytes was significantly lower than normal pregnancy values. This was also the case in peripheral blood of pregnant women with a history of recurrent spontaneous abortions. |
| doi_str_mv | 10.1016/0165-0378(89)90053-3 |
| format | Article |
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PBL of healthy pregnant women contained significantly more positive cells than those of non-pregnant controls. Furthermore, the number of receptor-containing cells increased in parallel with gestational age. In blood samples drawn during labour, as well as in those obtained from women with spontaneous abortion or clinical symptoms of threatened pre-term delivery, the percentage of positively stained lymphocytes was significantly lower than normal pregnancy values. This was also the case in peripheral blood of pregnant women with a history of recurrent spontaneous abortions.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/0165-0378(89)90053-3</identifier><identifier>PMID: 2614759</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>abortion ; Abortion, Habitual - immunology ; Abortion, Spontaneous - immunology ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gestational Age ; human pregnancy ; Humans ; Immunoassay ; Immunobiology ; Lymphocytes - physiology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Obstetric Labor, Premature - immunology ; peripheral blood lyphocytes ; Pregnancy - immunology ; Pregnancy Complications - immunology ; progesterone receptors ; Receptors, Progesterone - physiology</subject><ispartof>Journal of reproductive immunology, 1989-12, Vol.16 (3), p.239-247</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d3a1cb3da0aa34232412f6b61c954325999604d0478bcfd356905f61051800393</citedby><cites>FETCH-LOGICAL-c386t-d3a1cb3da0aa34232412f6b61c954325999604d0478bcfd356905f61051800393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0378(89)90053-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6719941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2614759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szekeres-Bartho, Julia</creatorcontrib><creatorcontrib>Reznikoff-Etievant, M.F.</creatorcontrib><creatorcontrib>Varga, P.</creatorcontrib><creatorcontrib>Pichon, M.-F.</creatorcontrib><creatorcontrib>Varga, Z.</creatorcontrib><creatorcontrib>Chaouat, G.</creatorcontrib><title>Lymphocytic progesterone receptors in normal and pathological human pregnancy</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>The progesterone receptor-specific monoclonal antibody (MoAb) mPRI was tested for its reactivity towards peripheral blood lymphocytes (PBL) of 49 healthy pregnant women, nine pregnant women with clinical symptoms of threatened preterm delivery, seven women with recurrent spontaneous abortion, ten women in labour and ten women with spontaneous abortion. Lymphocytes of 12 healthy age-matched non-pregnant volunteers were used as controls. Lymphocytes of nine healthy pregnant women at the 1st trimester of pregnancy and those of two non-pregnant donors were tested for the presence of estrogen and progesterone receptors by enzyme immunoassay.
PBL of healthy pregnant women contained significantly more positive cells than those of non-pregnant controls. Furthermore, the number of receptor-containing cells increased in parallel with gestational age. In blood samples drawn during labour, as well as in those obtained from women with spontaneous abortion or clinical symptoms of threatened pre-term delivery, the percentage of positively stained lymphocytes was significantly lower than normal pregnancy values. This was also the case in peripheral blood of pregnant women with a history of recurrent spontaneous abortions.</description><subject>abortion</subject><subject>Abortion, Habitual - immunology</subject><subject>Abortion, Spontaneous - immunology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gestational Age</subject><subject>human pregnancy</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunobiology</subject><subject>Lymphocytes - physiology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>Obstetric Labor, Premature - immunology</subject><subject>peripheral blood lyphocytes</subject><subject>Pregnancy - immunology</subject><subject>Pregnancy Complications - immunology</subject><subject>progesterone receptors</subject><subject>Receptors, Progesterone - physiology</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYh4Moc06_gUIPInqovmnSpLkIMvwHEy96DlmabpE2qUkn7NububGjhxDI-_xefnkQOsdwiwGzu3TKHAivritxIwBKkpMDNMYVL3LOgByi8R45RicxfgFgDgKP0KhgmPJSjNHbbN31S6_Xg9VZH_zCxMEE70wWjDb94EPMrMucD51qM-XqrFfD0rd-YXV6WK465VLOLJxyen2KjhrVRnO2uyfo8-nxY_qSz96fX6cPs1yTig15TRTWc1IrUIrQghQUFw2bM6xFSUlRCiEY0Boor-a6qUnJBJQNw1DiCoAIMkFX272p8fcqVZadjdq0rXLGr6LkglLMCp5AugV18DEG08g-2E6FtcQgNxblRpHcKJKVkH8WJUmxi93-1bwz9T6005bml7u5iklDE9LnbdxjjGMhKE7Y_RYzycWPNUFGbY3TprbJ7iBrb__v8Qt7cI1C</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Szekeres-Bartho, Julia</creator><creator>Reznikoff-Etievant, M.F.</creator><creator>Varga, P.</creator><creator>Pichon, M.-F.</creator><creator>Varga, Z.</creator><creator>Chaouat, G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891201</creationdate><title>Lymphocytic progesterone receptors in normal and pathological human pregnancy</title><author>Szekeres-Bartho, Julia ; Reznikoff-Etievant, M.F. ; Varga, P. ; Pichon, M.-F. ; Varga, Z. ; Chaouat, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d3a1cb3da0aa34232412f6b61c954325999604d0478bcfd356905f61051800393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>abortion</topic><topic>Abortion, Habitual - immunology</topic><topic>Abortion, Spontaneous - immunology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gestational Age</topic><topic>human pregnancy</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunobiology</topic><topic>Lymphocytes - physiology</topic><topic>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</topic><topic>Obstetric Labor, Premature - immunology</topic><topic>peripheral blood lyphocytes</topic><topic>Pregnancy - immunology</topic><topic>Pregnancy Complications - immunology</topic><topic>progesterone receptors</topic><topic>Receptors, Progesterone - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szekeres-Bartho, Julia</creatorcontrib><creatorcontrib>Reznikoff-Etievant, M.F.</creatorcontrib><creatorcontrib>Varga, P.</creatorcontrib><creatorcontrib>Pichon, M.-F.</creatorcontrib><creatorcontrib>Varga, Z.</creatorcontrib><creatorcontrib>Chaouat, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szekeres-Bartho, Julia</au><au>Reznikoff-Etievant, M.F.</au><au>Varga, P.</au><au>Pichon, M.-F.</au><au>Varga, Z.</au><au>Chaouat, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocytic progesterone receptors in normal and pathological human pregnancy</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>16</volume><issue>3</issue><spage>239</spage><epage>247</epage><pages>239-247</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>The progesterone receptor-specific monoclonal antibody (MoAb) mPRI was tested for its reactivity towards peripheral blood lymphocytes (PBL) of 49 healthy pregnant women, nine pregnant women with clinical symptoms of threatened preterm delivery, seven women with recurrent spontaneous abortion, ten women in labour and ten women with spontaneous abortion. Lymphocytes of 12 healthy age-matched non-pregnant volunteers were used as controls. Lymphocytes of nine healthy pregnant women at the 1st trimester of pregnancy and those of two non-pregnant donors were tested for the presence of estrogen and progesterone receptors by enzyme immunoassay.
PBL of healthy pregnant women contained significantly more positive cells than those of non-pregnant controls. Furthermore, the number of receptor-containing cells increased in parallel with gestational age. In blood samples drawn during labour, as well as in those obtained from women with spontaneous abortion or clinical symptoms of threatened pre-term delivery, the percentage of positively stained lymphocytes was significantly lower than normal pregnancy values. This was also the case in peripheral blood of pregnant women with a history of recurrent spontaneous abortions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2614759</pmid><doi>10.1016/0165-0378(89)90053-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of reproductive immunology, 1989-12, Vol.16 (3), p.239-247 |
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| language | eng |
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| subjects | abortion Abortion, Habitual - immunology Abortion, Spontaneous - immunology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gestational Age human pregnancy Humans Immunoassay Immunobiology Lymphocytes - physiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Obstetric Labor, Premature - immunology peripheral blood lyphocytes Pregnancy - immunology Pregnancy Complications - immunology progesterone receptors Receptors, Progesterone - physiology |
| title | Lymphocytic progesterone receptors in normal and pathological human pregnancy |
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