Intracellular localization of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei

Glycosyl-phosphatidylinositol-specific phospholipase C (GPI-PLC) is a membrane-bound enzyme of bloodstream forms of Trypanosoma brucei, which cleaves the GPI-membrane anchor of the variant surface glycoprotein forming diacylglycerol and 1,2-cyclic phosphate on the inositol ring. The cellular localiz...

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Veröffentlicht in:	Journal of cell science 1989-06, Vol.93 (2), p.233-240
Hauptverfasser:	Bulow, R, Griffiths, G, Webster, P, Stierhof, Y.D, Opperdoes, F.R, Overath, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences cell biology Cell Fractionation Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - ultrastructure detection electron microscopy enzymes Enzymes and enzyme inhibitors Flagella - drug effects Flagella - metabolism Flagella - ultrastructure Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology glycoproteins Glycosylphosphatidylinositol Diacylglycerol-Lyase Hydrolases immunoenzyme techniques Immunohistochemistry - methods Intracellular Membranes - drug effects Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure membranes Mice Microscopy, Electron - methods organelles Rats Substrate Specificity Trypanosoma brucei Trypanosoma brucei brucei - enzymology Trypsin - pharmacology Type C Phospholipases - metabolism
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