The fate of γL crystallins in rat lens during diabetic cataractogenesis as determined by a monoclonal antibody

We developed a monoclonal antibody against HPLC purified rat lens γL crystallins. This antibody was specific to both the polypeptides (19,000 and 21,000 daltons) which constituted the HPLC γ1 peak. Least reactivity was shown against γH (24,000b daltons). This antibody was used as a probe to detect t...

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Veröffentlicht in:	Current eye research 1989, Vol.8 (10), p.989-996
Hauptverfasser:	Swamy, M. S., Shyamala, M., Abraham, J., Garver, F. A., Abraham, E. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Antibody Specificity Biological and medical sciences Blotting, Western Cataract - etiology Cataract - metabolism Chromatography, High Pressure Liquid Crystallins - isolation & purification Crystallins - metabolism Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Enzyme-Linked Immunosorbent Assay Lens diseases Lens, Crystalline - metabolism Male Medical sciences Ophthalmology Rats Rats, Inbred Strains Solubility
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