Oocyte polarity and cell determination in early mammalian embryos
Knowledge on determination and differentiation in the mammalian embryo has not kept pace with discoveries in other phyla. Current concepts overlook well-established pathways leading to polarity in oocytes and embryos of other phyla, modern principles of totipotency in plants and animals, and axis fo...
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| Veröffentlicht in: | Molecular human reproduction 1997-10, Vol.3 (10), p.863-905 |
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| container_title | Molecular human reproduction |
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| creator | EDWARDS, R. G BEARD, H. K |
| description | Knowledge on determination and differentiation in the mammalian embryo has not kept pace with discoveries in other phyla. Current concepts overlook well-established pathways leading to polarity in oocytes and embryos of other phyla, modern principles of totipotency in plants and animals, and axis formation in lower vertebrates. Various models derived from invertebrates and frogs could be relevant to the situation in eutherian mammals, and we explore the nature of strict genetic controls in these species and its implications for early mammalian differentiation. Concepts on totipotency and related phenomena in animal and human embryos are examined and the possibility raised that two cell lines are formed in early human embryos from the 2-4 cell stage. Clinical consequences are assessed, including causes of the high incidence of chromosomal mosaicism in human embryos. Our interpretations are obviously speculative, and must be clarified by experimentation. |
| doi_str_mv | 10.1093/molehr/3.10.863 |
| format | Article |
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Our interpretations are obviously speculative, and must be clarified by experimentation.</description><identifier>ISSN: 1360-9947</identifier><identifier>ISSN: 1460-2407</identifier><identifier>EISSN: 1460-2407</identifier><identifier>DOI: 10.1093/molehr/3.10.863</identifier><identifier>PMID: 9395264</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Cell Differentiation - genetics ; Cell Differentiation - physiology ; Cell Polarity - genetics ; Cell Polarity - physiology ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryo, Mammalian - cytology ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development ; Fundamental and applied biological sciences. 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Clinical consequences are assessed, including causes of the high incidence of chromosomal mosaicism in human embryos. Our interpretations are obviously speculative, and must be clarified by experimentation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Polarity - genetics</subject><subject>Cell Polarity - physiology</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Mammals - embryology</subject><subject>Mammals - genetics</subject><subject>Oocytes - cytology</subject><subject>Oocytes - growth & development</subject><subject>Oocytes - physiology</subject><issn>1360-9947</issn><issn>1460-2407</issn><issn>1460-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UD1PwzAQtRColMLMhJQBsaX1V-J4rCq-pEpdYI6usS2M7LjY6ZB_j6tGne7dvXdPdw-hR4KXBEu28sHpn7hiuVs2NbtCc8JrXFKOxXXGLGMpubhFdyn9YkwErZoZmkkmK1rzOVrvQjcOujgEB9EOYwG9KjrtXKH0oKO3PQw29IXtCw3RjYUH78FZyL3fxzGke3RjwCX9MNUF-n57_dp8lNvd--dmvS07TpuhJHVtMCOGNwbjilEplRT7ihjVcG44VxXpZKUYFsRoDgwI1w0FpSUB3uiKLdDL2fcQw99Rp6H1Np0uhV6HY2qF5PkpzLJwdRZ2MaQUtWkP0XqIY0twewqtPYfWstMgh5Y3nibr495rddFPKWX-eeIhdeBMhL6z6SKjWAhGBfsHnfR1nA</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>EDWARDS, R. G</creator><creator>BEARD, H. 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Neurulation</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Mammals - embryology</topic><topic>Mammals - genetics</topic><topic>Oocytes - cytology</topic><topic>Oocytes - growth & development</topic><topic>Oocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDWARDS, R. G</creatorcontrib><creatorcontrib>BEARD, H. 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| ispartof | Molecular human reproduction, 1997-10, Vol.3 (10), p.863-905 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Cell Differentiation - genetics Cell Differentiation - physiology Cell Polarity - genetics Cell Polarity - physiology Early stages. Segmentation. Gastrulation. Neurulation Embryo, Mammalian - cytology Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Fundamental and applied biological sciences. Psychology Humans Mammals - embryology Mammals - genetics Oocytes - cytology Oocytes - growth & development Oocytes - physiology |
| title | Oocyte polarity and cell determination in early mammalian embryos |
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