The Effects of Bupivacaine, L-Nitro-L-Arginine-Methyl Ester, and Phenylephrine on Cardiovascular Adaptations to Asphyxia in the Preterm Fetal Lamb

The preterm fetal lamb that is exposed to clinically relevant plasma concentrations of lidocaine loses its cardiovascular adaptations to asphyxia, and its condition deteriorates further.Nitric oxide (NO) is an important regulator of vascular tone, and local anesthetics are known to inhibit endotheli...

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Veröffentlicht in:	Anesthesia and analgesia 1997-12, Vol.85 (6), p.1299-1306
Hauptverfasser:	Santos, Alan C., Yun, Esther M., Bobby, Paul D., Noble, George, Arthur, G. Richard, Finster, Mieczyslaw
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Anesthetics, Local - pharmacology Animals Animals, Newborn - physiology Asphyxia - blood Asphyxia - physiopathology Biological and medical sciences Blood Pressure - drug effects Bupivacaine - pharmacology Carbon Dioxide - blood Drug toxicity and drugs side effects treatment Female Fetal Blood - chemistry Fetal Blood - drug effects Gestational Age Heart Rate - drug effects Hemodynamics - drug effects Hydrogen-Ion Concentration Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Oxygen - blood Pharmacology. Drug treatments Phenylephrine - pharmacology Pregnancy Regional Blood Flow - drug effects Sheep Toxicity: cardiovascular system Vasoconstrictor Agents - pharmacology
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