Clocinnamox dose-dependently antagonizes morphine-analgesia and [ [formula omitted]]DAMGO binding in rats

Clocinnamox is a long-lasting, nonequilibrium, μ-opioid receptor antagonist in mice and monkeys. The present studies examined the in vivo and ex vivo effects of clocinnamox in rats. Under control conditions, morphine dose-dependently increased tail-withdrawal latencies from 50°C water, with a mean E...

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Veröffentlicht in:	European journal of pharmacology 1997-10, Vol.337 (1), p.27-34
Hauptverfasser:	Paronis, Carol A., Woods, James H.
Format:	Artikel
Sprache:	eng
Schlagworte:	[ [formula omitted]]DAMGO ([ [formula omitted]][ d-Ala 2, N-Me-Phe 4,Gly 5-ol]-enkephalin) Analgesia Analgesics, Opioid - antagonists & inhibitors Animals Biological and medical sciences Cinnamates - pharmacology Clocinnamox Dose-Response Relationship, Drug Enkephalin, Ala-MePhe-Gly Enkephalins - metabolism Female Kinetics Medical sciences Membranes - drug effects Membranes - metabolism Morphine Morphine - antagonists & inhibitors Morphine Derivatives - pharmacology Narcotic Antagonists - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opioid receptor binding Pain Measurement - drug effects Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rat Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Time Factors
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