Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia
The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoprotein...
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| Veröffentlicht in: | European journal of clinical pharmacology 1989-11, Vol.37 (6), p.545-550 |
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| container_issue | 6 |
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| container_title | European journal of clinical pharmacology |
| container_volume | 37 |
| creator | BARD, J.-M LUC, G DOUSTE-BLAZY, P DROUIN, P ZIEGLER, O JACOTOT, B DACHET, C DE GENNES, J.-L FRUCHART, J.-C |
| description | The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased. |
| doi_str_mv | 10.1007/BF00562541 |
| format | Article |
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It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00562541</identifier><identifier>PMID: 2693115</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Anticholesteremic Agents - pharmacology ; Apolipoproteins - blood ; Biological and medical sciences ; Cholesterol - biosynthesis ; Cholesterol - blood ; Female ; General and cellular metabolism. Vitamins ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypercholesterolemia - drug therapy ; Immunoenzyme Techniques ; Lipoproteins - blood ; Lovastatin - analogs & derivatives ; Lovastatin - pharmacology ; Lovastatin - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Phospholipids - blood ; Simvastatin ; Triglycerides - blood</subject><ispartof>European journal of clinical pharmacology, 1989-11, Vol.37 (6), p.545-550</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-f7c25f803f73b0c207b03364e0bf64e9071155eeacbe2bf3bb3e48c1d8bfdb2e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6687071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2693115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARD, J.-M</creatorcontrib><creatorcontrib>LUC, G</creatorcontrib><creatorcontrib>DOUSTE-BLAZY, P</creatorcontrib><creatorcontrib>DROUIN, P</creatorcontrib><creatorcontrib>ZIEGLER, O</creatorcontrib><creatorcontrib>JACOTOT, B</creatorcontrib><creatorcontrib>DACHET, C</creatorcontrib><creatorcontrib>DE GENNES, J.-L</creatorcontrib><creatorcontrib>FRUCHART, J.-C</creatorcontrib><title>Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>Apolipoproteins - blood</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - biosynthesis</subject><subject>Cholesterol - blood</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Immunoenzyme Techniques</subject><subject>Lipoproteins - blood</subject><subject>Lovastatin - analogs & derivatives</subject><subject>Lovastatin - pharmacology</subject><subject>Lovastatin - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipids - blood</subject><subject>Simvastatin</subject><subject>Triglycerides - blood</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtLBTEQhYMoen009kIKsRBXJ8k-SxVfINhovSTZCTeyu1mTXMXOn27URW3m-TGcOYTsMzhlANXZxTVAUfIiZ2tkwXLBMwY5WycLAMGysqlgi2yH8AzAigbEJtnkZSMYKxbk48oY1JE6Q4MdXmWIMtqRupFOvQyDpL2dbBdOqJxcKt3kXUQ7BirHjv4b0En6aHWPgX430eIYA32zcUknbwfp3-nyfUKvly5BEb3rJQ5W7pINI_uAe3PeIU_XV4-Xt9n9w83d5fl9pjkvY2YqzQtTgzCVUKA5VAqEKHMEZVJsoErvFIhSK-TKCKUE5rVmXa1MpziKHXL0czcJflklBe1gg8a-lyO6VWirJhc1b1gCj39A7V0IHk07628ZtF92t392J_hgvrpSA3a_6Oxv2h_Oexm07I2Xo7bhFyvLukrKxSftSIrP</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>BARD, J.-M</creator><creator>LUC, G</creator><creator>DOUSTE-BLAZY, P</creator><creator>DROUIN, P</creator><creator>ZIEGLER, O</creator><creator>JACOTOT, B</creator><creator>DACHET, C</creator><creator>DE GENNES, J.-L</creator><creator>FRUCHART, J.-C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198911</creationdate><title>Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia</title><author>BARD, J.-M ; LUC, G ; DOUSTE-BLAZY, P ; DROUIN, P ; ZIEGLER, O ; JACOTOT, B ; DACHET, C ; DE GENNES, J.-L ; FRUCHART, J.-C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-f7c25f803f73b0c207b03364e0bf64e9071155eeacbe2bf3bb3e48c1d8bfdb2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>Apolipoproteins - blood</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - biosynthesis</topic><topic>Cholesterol - blood</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Immunoenzyme Techniques</topic><topic>Lipoproteins - blood</topic><topic>Lovastatin - analogs & derivatives</topic><topic>Lovastatin - pharmacology</topic><topic>Lovastatin - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipids - blood</topic><topic>Simvastatin</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARD, J.-M</creatorcontrib><creatorcontrib>LUC, G</creatorcontrib><creatorcontrib>DOUSTE-BLAZY, P</creatorcontrib><creatorcontrib>DROUIN, P</creatorcontrib><creatorcontrib>ZIEGLER, O</creatorcontrib><creatorcontrib>JACOTOT, B</creatorcontrib><creatorcontrib>DACHET, C</creatorcontrib><creatorcontrib>DE GENNES, J.-L</creatorcontrib><creatorcontrib>FRUCHART, J.-C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARD, J.-M</au><au>LUC, G</au><au>DOUSTE-BLAZY, P</au><au>DROUIN, P</au><au>ZIEGLER, O</au><au>JACOTOT, B</au><au>DACHET, C</au><au>DE GENNES, J.-L</au><au>FRUCHART, J.-C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1989-11</date><risdate>1989</risdate><volume>37</volume><issue>6</issue><spage>545</spage><epage>550</epage><pages>545-550</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2693115</pmid><doi>10.1007/BF00562541</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1989-11, Vol.37 (6), p.545-550 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Anticholesteremic Agents - pharmacology Apolipoproteins - blood Biological and medical sciences Cholesterol - biosynthesis Cholesterol - blood Female General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypercholesterolemia - drug therapy Immunoenzyme Techniques Lipoproteins - blood Lovastatin - analogs & derivatives Lovastatin - pharmacology Lovastatin - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments Phospholipids - blood Simvastatin Triglycerides - blood |
| title | Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia |
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