Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients
Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neu...
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| Veröffentlicht in: | British journal of psychiatry 1989-11, Vol.155 (5), p.680-685 |
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| container_end_page | 685 |
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| container_title | British journal of psychiatry |
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| creator | Flaskos, J. Theophilopoulos, N. George, A. J. |
| description | Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin. |
| doi_str_mv | 10.1192/bjp.155.5.680 |
| format | Article |
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J.</creator><creatorcontrib>Flaskos, J. ; Theophilopoulos, N. ; George, A. J.</creatorcontrib><description>Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.155.5.680</identifier><identifier>PMID: 2611598</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Agoraphobia - blood ; Agoraphobia - diagnosis ; Agoraphobia - metabolism ; Blood Platelets - enzymology ; Blood Platelets - metabolism ; Depressive Disorder - blood ; Depressive Disorder - diagnosis ; Depressive Disorder - metabolism ; Diagnosis, Differential ; Female ; Humans ; Male ; Monoamine Oxidase - metabolism ; Psychiatric Status Rating Scales ; Serotonin - metabolism</subject><ispartof>British journal of psychiatry, 1989-11, Vol.155 (5), p.680-685</ispartof><rights>Copyright © Royal College of Psychiatrists, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</citedby><cites>FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000018195/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,782,786,27931,27932,55635</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2611598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flaskos, J.</creatorcontrib><creatorcontrib>Theophilopoulos, N.</creatorcontrib><creatorcontrib>George, A. 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These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</description><subject>Adult</subject><subject>Agoraphobia - blood</subject><subject>Agoraphobia - diagnosis</subject><subject>Agoraphobia - metabolism</subject><subject>Blood Platelets - enzymology</subject><subject>Blood Platelets - metabolism</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Psychiatric Status Rating Scales</subject><subject>Serotonin - metabolism</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1v2zAQhokiReKmHTsWUJZsckiJH-JoBElTIEUyNEsXgh9nm64kKiTdRv--LGwEyNDp7vA-eA94EPpM8JIQ2VyZ3bQkjC3Zknf4HVoQKpqaUM5O0AJjLGrSMHyGPqS0K2dLG3GKThtOCJPdAv187HWGHnL1PYxBD36E6uHFO52gWtnsf_s8V3p0FavvZhfDy5zjPOUD-FSWX1D5sVptQtTTNhhvq0edPYw5fUTv17pP8Ok4z9HT7c2P67v6_uHrt-vVfW1bRnPtKAWJOTjWdZIITdtGSiYs57qhVBgHlgkjbEdaAmS9NhoMldyAJA5zzNtzdHnonWJ43kPKavDJQt_rEcI-KSFp25EGF7A-gDaGlCKs1RT9oOOsCFb_XKriUhWXiqnisvBfjsV7M4B7pY_ySn5xyLd-s_3jI6hopzTb7ZuOq-NPPZjo3QbULuzjWIT85-tfyueLCw</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Flaskos, J.</creator><creator>Theophilopoulos, N.</creator><creator>George, A. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Agoraphobia - blood</topic><topic>Agoraphobia - diagnosis</topic><topic>Agoraphobia - metabolism</topic><topic>Blood Platelets - enzymology</topic><topic>Blood Platelets - metabolism</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Monoamine Oxidase - metabolism</topic><topic>Psychiatric Status Rating Scales</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flaskos, J.</creatorcontrib><creatorcontrib>Theophilopoulos, N.</creatorcontrib><creatorcontrib>George, A. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>155</volume><issue>5</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>2611598</pmid><doi>10.1192/bjp.155.5.680</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of psychiatry, 1989-11, Vol.155 (5), p.680-685 |
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| language | eng |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Adult Agoraphobia - blood Agoraphobia - diagnosis Agoraphobia - metabolism Blood Platelets - enzymology Blood Platelets - metabolism Depressive Disorder - blood Depressive Disorder - diagnosis Depressive Disorder - metabolism Diagnosis, Differential Female Humans Male Monoamine Oxidase - metabolism Psychiatric Status Rating Scales Serotonin - metabolism |
| title | Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients |
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