Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients

Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:British journal of psychiatry 1989-11, Vol.155 (5), p.680-685
Hauptverfasser: Flaskos, J., Theophilopoulos, N., George, A. J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 685
container_issue 5
container_start_page 680
container_title British journal of psychiatry
container_volume 155
creator Flaskos, J.
Theophilopoulos, N.
George, A. J.
description Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.
doi_str_mv 10.1192/bjp.155.5.680
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79438120</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1192_bjp_155_5_680</cupid><sourcerecordid>79438120</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</originalsourceid><addsrcrecordid>eNp1kD1v2zAQhokiReKmHTsWUJZsckiJH-JoBElTIEUyNEsXgh9nm64kKiTdRv--LGwEyNDp7vA-eA94EPpM8JIQ2VyZ3bQkjC3Zknf4HVoQKpqaUM5O0AJjLGrSMHyGPqS0K2dLG3GKThtOCJPdAv187HWGHnL1PYxBD36E6uHFO52gWtnsf_s8V3p0FavvZhfDy5zjPOUD-FSWX1D5sVptQtTTNhhvq0edPYw5fUTv17pP8Ok4z9HT7c2P67v6_uHrt-vVfW1bRnPtKAWJOTjWdZIITdtGSiYs57qhVBgHlgkjbEdaAmS9NhoMldyAJA5zzNtzdHnonWJ43kPKavDJQt_rEcI-KSFp25EGF7A-gDaGlCKs1RT9oOOsCFb_XKriUhWXiqnisvBfjsV7M4B7pY_ySn5xyLd-s_3jI6hopzTb7ZuOq-NPPZjo3QbULuzjWIT85-tfyueLCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79438120</pqid></control><display><type>article</type><title>Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients</title><source>MEDLINE</source><source>Cambridge University Press Journals Complete</source><creator>Flaskos, J. ; Theophilopoulos, N. ; George, A. J.</creator><creatorcontrib>Flaskos, J. ; Theophilopoulos, N. ; George, A. J.</creatorcontrib><description>Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.155.5.680</identifier><identifier>PMID: 2611598</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Agoraphobia - blood ; Agoraphobia - diagnosis ; Agoraphobia - metabolism ; Blood Platelets - enzymology ; Blood Platelets - metabolism ; Depressive Disorder - blood ; Depressive Disorder - diagnosis ; Depressive Disorder - metabolism ; Diagnosis, Differential ; Female ; Humans ; Male ; Monoamine Oxidase - metabolism ; Psychiatric Status Rating Scales ; Serotonin - metabolism</subject><ispartof>British journal of psychiatry, 1989-11, Vol.155 (5), p.680-685</ispartof><rights>Copyright © Royal College of Psychiatrists, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</citedby><cites>FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000018195/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,782,786,27931,27932,55635</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2611598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flaskos, J.</creatorcontrib><creatorcontrib>Theophilopoulos, N.</creatorcontrib><creatorcontrib>George, A. J.</creatorcontrib><title>Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</description><subject>Adult</subject><subject>Agoraphobia - blood</subject><subject>Agoraphobia - diagnosis</subject><subject>Agoraphobia - metabolism</subject><subject>Blood Platelets - enzymology</subject><subject>Blood Platelets - metabolism</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Psychiatric Status Rating Scales</subject><subject>Serotonin - metabolism</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1v2zAQhokiReKmHTsWUJZsckiJH-JoBElTIEUyNEsXgh9nm64kKiTdRv--LGwEyNDp7vA-eA94EPpM8JIQ2VyZ3bQkjC3Zknf4HVoQKpqaUM5O0AJjLGrSMHyGPqS0K2dLG3GKThtOCJPdAv187HWGHnL1PYxBD36E6uHFO52gWtnsf_s8V3p0FavvZhfDy5zjPOUD-FSWX1D5sVptQtTTNhhvq0edPYw5fUTv17pP8Ok4z9HT7c2P67v6_uHrt-vVfW1bRnPtKAWJOTjWdZIITdtGSiYs57qhVBgHlgkjbEdaAmS9NhoMldyAJA5zzNtzdHnonWJ43kPKavDJQt_rEcI-KSFp25EGF7A-gDaGlCKs1RT9oOOsCFb_XKriUhWXiqnisvBfjsV7M4B7pY_ySn5xyLd-s_3jI6hopzTb7ZuOq-NPPZjo3QbULuzjWIT85-tfyueLCw</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Flaskos, J.</creator><creator>Theophilopoulos, N.</creator><creator>George, A. J.</creator><general>Cambridge University Press</general><general>RCP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients</title><author>Flaskos, J. ; Theophilopoulos, N. ; George, A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-d44e906ed588917a4329957c66a2447bdec57b7c8131e1ffbaeb496be91d06063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Agoraphobia - blood</topic><topic>Agoraphobia - diagnosis</topic><topic>Agoraphobia - metabolism</topic><topic>Blood Platelets - enzymology</topic><topic>Blood Platelets - metabolism</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Monoamine Oxidase - metabolism</topic><topic>Psychiatric Status Rating Scales</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flaskos, J.</creatorcontrib><creatorcontrib>Theophilopoulos, N.</creatorcontrib><creatorcontrib>George, A. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flaskos, J.</au><au>Theophilopoulos, N.</au><au>George, A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>155</volume><issue>5</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>2611598</pmid><doi>10.1192/bjp.155.5.680</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0007-1250
ispartof British journal of psychiatry, 1989-11, Vol.155 (5), p.680-685
issn 0007-1250
1472-1465
language eng
recordid cdi_proquest_miscellaneous_79438120
source MEDLINE; Cambridge University Press Journals Complete
subjects Adult
Agoraphobia - blood
Agoraphobia - diagnosis
Agoraphobia - metabolism
Blood Platelets - enzymology
Blood Platelets - metabolism
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - metabolism
Diagnosis, Differential
Female
Humans
Male
Monoamine Oxidase - metabolism
Psychiatric Status Rating Scales
Serotonin - metabolism
title Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T19%3A22%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Platelet%20Monoamine%20Oxidase%20Activity%20and%205-Hydroxytryptamine%20Uptake%20in%20Agoraphobic%20Patients&rft.jtitle=British%20journal%20of%20psychiatry&rft.au=Flaskos,%20J.&rft.date=1989-11-01&rft.volume=155&rft.issue=5&rft.spage=680&rft.epage=685&rft.pages=680-685&rft.issn=0007-1250&rft.eissn=1472-1465&rft_id=info:doi/10.1192/bjp.155.5.680&rft_dat=%3Cproquest_cross%3E79438120%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79438120&rft_id=info:pmid/2611598&rft_cupid=10_1192_bjp_155_5_680&rfr_iscdi=true