Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta

The purpose of this study was to identify the duration of exposure of islets to interleukin 1beta (IL-1beta) that results in irreversible damage. Treatment of rat islets for 18 h with IL-1beta results in an inhibition of glucose-stimulated insulin secretion, mitochondrial aconitase activity, and tot...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-12, Vol.138 (12), p.5301-5307
Hauptverfasser:	Scarim, A L, Heitmeier, M R, Corbett, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - antagonists & inhibitors Aconitate Hydratase - metabolism Animals Dactinomycin - pharmacology Enzyme Induction Enzyme Inhibitors - pharmacology Hormone Antagonists - pharmacology Humans Insulin - metabolism Insulin Antagonists - pharmacology Insulin Secretion Interleukin-1 - administration & dosage Interleukin-1 - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans - pathology Male Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - pharmacology Protein Biosynthesis Rats Rats, Sprague-Dawley Time Factors
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