Consequences of Growth Hormone Deficiency on Cardiac Structure, Function, and β-Adrenergic Pathway: Studies in Mutant Dwarf Rats

Abstract To evaluate GH’s role in cardiac physiology and its interrelationship with the β-adrenergic system, we studied GH-deficient dwarf (dw/dw) and control rats in 4 groups of 20 each: dwarf group receiving placebo, dwarf-GH group receiving 2 mg/kg GH, dwarf-GH-propranolol group receiving 2 mg/kg...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-12, Vol.138 (12), p.5161-5169
Hauptverfasser:	Cittadini, Antonio, Strömer, Hinrik, Vatner, Dorothy E., Grossman, Jessica D., Katz, Sarah E., Clark, Ross, Morgan, James P., Douglas, Pamela S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adenosine Adenosine triphosphatase Adenylate cyclase Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Adrenergic receptors Animals Dwarfism - metabolism Dwarfism - pathology Dwarfism - physiopathology Female Growth factors Growth Hormone - deficiency Growth Hormone - pharmacology Growth hormones Heart Heart - drug effects Heart - physiopathology In Vitro Techniques Insulin-like growth factor I Isoproterenol - pharmacology Muscle contraction Myocardium - pathology Myocytes Physiology Placebos Propranolol Propranolol - pharmacology Rats Rats, Inbred Lew Rats, Mutant Strains Receptor density Receptors (physiology) Receptors, Adrenergic, beta - physiology Structure-function relationships Ventricle Ventricular Function, Left - drug effects
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