Na+/H+ exchanger inhibitor HOE-642 improves cardioplegic myocardial preservation under both normothermic and hypothermic conditions

The sarcolemmal Na+/H+ exchanger has been implicated in the pathogenesis of myocardial injury during ischemia/reperfusion. We determined the cardioprotective efficacy of the Na+/H+ exchanger inhibitor HOE-642 (HOE) as an alternative, adjunct, or additive to cardioplegia (CP). In isolated working rat...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1997-11, Vol.96 (9), p.II-266
Hauptverfasser:	SHIPOLINI, A. R, GALINANES, M, EDMONDSON, S. J, HEARSE, D. J, AVKIRAN, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Guanidines - pharmacology Heart Arrest, Induced Hypothermia, Induced Male Medical sciences Rats Rats, Wistar Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - pharmacology Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Zusammenfassung:	The sarcolemmal Na+/H+ exchanger has been implicated in the pathogenesis of myocardial injury during ischemia/reperfusion. We determined the cardioprotective efficacy of the Na+/H+ exchanger inhibitor HOE-642 (HOE) as an alternative, adjunct, or additive to cardioplegia (CP). In isolated working rat hearts (n=6 per group) subjected to 25 minutes of ischemia at 37 degrees C, the postischemic recovery of aortic flow (AF) was 5+/-3% in controls; this was improved to 18+/-4% by the preischemic infusion of 1 micromol/L HOE (P
ISSN:	0009-7322 1524-4539