Fatal disseminated intravascular coagulation after autologous islet transplantation
Autologous islet transplantation after pancreatectomy has been used in the surgical management of patients with intractable pain secondary to chronic pancreatitis. Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transpla...
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Veröffentlicht in: | Human pathology 1997-11, Vol.28 (11), p.1295-1298 |
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creator | Froberg, M.Kent Leone, John P Jessurun, Jose Sutherland, David E.R |
description | Autologous islet transplantation after pancreatectomy has been used in the surgical management of patients with intractable pain secondary to chronic pancreatitis. Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transplantation. Transplantation of autologous islet cells harvested from the patient's pancreas into the liver through portal vein infusion has led to long-term euglycemia in 30% to 50% of patients. We report the development of disseminated intravascular coagulation and fatal hemorrhagic shock in a 36-year-old woman after total pancreatectomy and autologous islet transplantation through retrograde infusion into the splenic vein. We report the clinical and pathological findings and discuss the possible pathophysiological mechanisms involved in the development of disseminated intravascular coagulation after this procedure. |
doi_str_mv | 10.1016/S0046-8177(97)90204-5 |
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Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transplantation. Transplantation of autologous islet cells harvested from the patient's pancreas into the liver through portal vein infusion has led to long-term euglycemia in 30% to 50% of patients. We report the development of disseminated intravascular coagulation and fatal hemorrhagic shock in a 36-year-old woman after total pancreatectomy and autologous islet transplantation through retrograde infusion into the splenic vein. We report the clinical and pathological findings and discuss the possible pathophysiological mechanisms involved in the development of disseminated intravascular coagulation after this procedure.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(97)90204-5</identifier><identifier>PMID: 9385936</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Associated diseases and complications ; Biological and medical sciences ; chronic pancreatitis ; Diabetes Mellitus, Type 2 - complications ; Diabetes. Impaired glucose tolerance ; disseminated intravascular coagulation ; Disseminated Intravascular Coagulation - etiology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fatal Outcome ; Female ; Humans ; Immunohistochemistry ; Insulin - analysis ; islet transplantation ; Islets of Langerhans Transplantation - adverse effects ; Lung - chemistry ; Lung - pathology ; Medical sciences ; Pancreatitis - complications ; Pancreatitis - surgery ; Shock, Hemorrhagic - etiology ; trypsin ; Trypsin - analysis</subject><ispartof>Human pathology, 1997-11, Vol.28 (11), p.1295-1298</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-c26ddebdb27bb833ea2a29a941d5c799707d80618ed9407b270a1105489962da3</citedby><cites>FETCH-LOGICAL-c418t-c26ddebdb27bb833ea2a29a941d5c799707d80618ed9407b270a1105489962da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817797902045$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2101953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9385936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Froberg, M.Kent</creatorcontrib><creatorcontrib>Leone, John P</creatorcontrib><creatorcontrib>Jessurun, Jose</creatorcontrib><creatorcontrib>Sutherland, David E.R</creatorcontrib><title>Fatal disseminated intravascular coagulation after autologous islet transplantation</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Autologous islet transplantation after pancreatectomy has been used in the surgical management of patients with intractable pain secondary to chronic pancreatitis. Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transplantation. Transplantation of autologous islet cells harvested from the patient's pancreas into the liver through portal vein infusion has led to long-term euglycemia in 30% to 50% of patients. We report the development of disseminated intravascular coagulation and fatal hemorrhagic shock in a 36-year-old woman after total pancreatectomy and autologous islet transplantation through retrograde infusion into the splenic vein. We report the clinical and pathological findings and discuss the possible pathophysiological mechanisms involved in the development of disseminated intravascular coagulation after this procedure.</description><subject>Adult</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>chronic pancreatitis</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>disseminated intravascular coagulation</subject><subject>Disseminated Intravascular Coagulation - etiology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Insulin - analysis</subject><subject>islet transplantation</subject><subject>Islets of Langerhans Transplantation - adverse effects</subject><subject>Lung - chemistry</subject><subject>Lung - pathology</subject><subject>Medical sciences</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - surgery</subject><subject>Shock, Hemorrhagic - etiology</subject><subject>trypsin</subject><subject>Trypsin - analysis</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_QdiDiB5W87HZbE4i4hcUPKjnMJtMJbLdrUm24L83taVXYSAD88zk5SHkjNFrRll980ZpVZcNU-pSqytNOa1KuUcmTApeNkLzfTLZIUfkOMYvShmTlTwkh1o0Uot6Qt4eIUFXOB8jLnwPCV3h-xRgBdGOHYTCDvCZm-SHvoB5wlDAmIZu-BzGWPjYYSoy3sdlB336w07IwRy6iKfbd0o-Hh_e75_L2evTy_3drLQVa1Jpee0ctq7lqm0bIRA4cA26Yk5apbWiyjW0Zg06XVGVMQqMUVk1WtfcgZiSi83dZRi-R4zJLHy02OUgmMMZpSshlGAZlBvQhiHGgHOzDH4B4ccwatYyzZ9MszZldK61TCPz3tn2g7FdoNttbe3l-fl2nmVBN88arI87jOfTWoqM3W4wzDJWHoOJ1mNv0fmANhk3-H-C_AIoXZIY</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Froberg, M.Kent</creator><creator>Leone, John P</creator><creator>Jessurun, Jose</creator><creator>Sutherland, David E.R</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Fatal disseminated intravascular coagulation after autologous islet transplantation</title><author>Froberg, M.Kent ; Leone, John P ; Jessurun, Jose ; Sutherland, David E.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c26ddebdb27bb833ea2a29a941d5c799707d80618ed9407b270a1105489962da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>chronic pancreatitis</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>disseminated intravascular coagulation</topic><topic>Disseminated Intravascular Coagulation - etiology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Insulin - analysis</topic><topic>islet transplantation</topic><topic>Islets of Langerhans Transplantation - adverse effects</topic><topic>Lung - chemistry</topic><topic>Lung - pathology</topic><topic>Medical sciences</topic><topic>Pancreatitis - complications</topic><topic>Pancreatitis - surgery</topic><topic>Shock, Hemorrhagic - etiology</topic><topic>trypsin</topic><topic>Trypsin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Froberg, M.Kent</creatorcontrib><creatorcontrib>Leone, John P</creatorcontrib><creatorcontrib>Jessurun, Jose</creatorcontrib><creatorcontrib>Sutherland, David E.R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Froberg, M.Kent</au><au>Leone, John P</au><au>Jessurun, Jose</au><au>Sutherland, David E.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatal disseminated intravascular coagulation after autologous islet transplantation</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>28</volume><issue>11</issue><spage>1295</spage><epage>1298</epage><pages>1295-1298</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Autologous islet transplantation after pancreatectomy has been used in the surgical management of patients with intractable pain secondary to chronic pancreatitis. Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transplantation. Transplantation of autologous islet cells harvested from the patient's pancreas into the liver through portal vein infusion has led to long-term euglycemia in 30% to 50% of patients. We report the development of disseminated intravascular coagulation and fatal hemorrhagic shock in a 36-year-old woman after total pancreatectomy and autologous islet transplantation through retrograde infusion into the splenic vein. We report the clinical and pathological findings and discuss the possible pathophysiological mechanisms involved in the development of disseminated intravascular coagulation after this procedure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9385936</pmid><doi>10.1016/S0046-8177(97)90204-5</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Associated diseases and complications Biological and medical sciences chronic pancreatitis Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance disseminated intravascular coagulation Disseminated Intravascular Coagulation - etiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fatal Outcome Female Humans Immunohistochemistry Insulin - analysis islet transplantation Islets of Langerhans Transplantation - adverse effects Lung - chemistry Lung - pathology Medical sciences Pancreatitis - complications Pancreatitis - surgery Shock, Hemorrhagic - etiology trypsin Trypsin - analysis |
title | Fatal disseminated intravascular coagulation after autologous islet transplantation |
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