Identification of the bcl-2 family of genes in the rat retina

Retinal ganglion cells die by apoptosis after axotomy, and this process may reflect altered expression of cell-death genes. Several of these genes, including bcl-2, bcl-x, and bax, share homology at the amino acid level in the BH1 and BH2 domains, through which they also interact. To understand thei...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1997-11, Vol.38 (12), p.2545-2553
Hauptverfasser:	Levin, LA, Schlamp, CL, Spieldoch, RL, Geszvain, KM, Nickells, RW
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Axotomy bcl-X Protein Biological and medical sciences Blotting, Northern DNA Primers - chemistry Eye and associated structures. Visual pathways and centers. Vision Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Genes, bcl-2 - physiology In Situ Hybridization Molecular Sequence Data Nerve Crush Optic Nerve Injuries Polymerase Chain Reaction Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Retina - metabolism Retinal Ganglion Cells - metabolism RNA - isolation & purification RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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