Lack of Infectivity of HIV-1 Integrase Zinc Finger-like Domain Mutant with Morphologically Normal Maturation

The integrase (IN) encoded by human immunodeficiency virus type-1 (HIV-1) is required for integration of the viral DNA into a host cell chromosome. The function of the highly conserved HHCC motif in the HIV-1 IN amino-terminal zinc finger-like domain is still unknown. In this study, we examined the...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-10, Vol.239 (3), p.715-722
Hauptverfasser:	Nakamura, Tahei, Masuda, Takao, Goto, Toshiyuki, Sano, Kouichi, Nakai, Masuyo, Harada, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption AIDS/HIV Animals COS Cells HeLa Cells HIV Infections - enzymology HIV Infections - virology HIV Integrase - genetics HIV-1 - enzymology HIV-1 - genetics HIV-1 - physiology HIV-1 - ultrastructure Humans Point Mutation Protein Structure, Tertiary Virion - physiology Virion - ultrastructure Virus Replication Zinc Fingers - genetics
Online-Zugang:	Volltext
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