Differential Expression of Egr‐1‐Like DNA‐Binding Activities in the Naive Rat Brain and After Excitatory Stimulation
: Egr‐1 and related proteins are inducible transcription factors within the brain recognizing the same consensus DNA sequence. Three Egr DNA‐binding activities were observed in regions of the naive rat brain. Egr‐1 was present in all brain regions examined. Bands composed, at least in part, of Egr‐2...
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| Veröffentlicht in: | Journal of neurochemistry 1997-12, Vol.69 (6), p.2227-2237 |
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| container_title | Journal of neurochemistry |
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| creator | Beckmann, Alison M. Davidson, Mark S. Goodenough, Sharon Wilce, Peter A. |
| description | : Egr‐1 and related proteins are inducible transcription factors within the brain recognizing the same consensus DNA sequence. Three Egr DNA‐binding activities were observed in regions of the naive rat brain. Egr‐1 was present in all brain regions examined. Bands composed, at least in part, of Egr‐2 and Egr‐3 were present in different relative amounts in the cerebral cortex, striatum, hippocampus, thalamus, and midbrain. All had similar affinity and specificity for the Egr consensus DNA recognition sequence. Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr‐1 and Egr‐2/3 DNA‐binding activities in the cerebral cortex, hippocampus, and cerebellum. All convulsants induced Egr‐1 and Egr‐2 immunoreactivity in the cerebral cortex and hippocampus. These data indicate that the members of the Egr family are regulated at different levels and may interact at promoters containing the Egr consensus sequence to fine tune a program of gene expression resulting from excitatory stimuli. |
| doi_str_mv | 10.1046/j.1471-4159.1997.69062227.x |
| format | Article |
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Three Egr DNA‐binding activities were observed in regions of the naive rat brain. Egr‐1 was present in all brain regions examined. Bands composed, at least in part, of Egr‐2 and Egr‐3 were present in different relative amounts in the cerebral cortex, striatum, hippocampus, thalamus, and midbrain. All had similar affinity and specificity for the Egr consensus DNA recognition sequence. Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr‐1 and Egr‐2/3 DNA‐binding activities in the cerebral cortex, hippocampus, and cerebellum. All convulsants induced Egr‐1 and Egr‐2 immunoreactivity in the cerebral cortex and hippocampus. These data indicate that the members of the Egr family are regulated at different levels and may interact at promoters containing the Egr consensus sequence to fine tune a program of gene expression resulting from excitatory stimuli.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.1997.69062227.x</identifier><identifier>PMID: 9375653</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Behavior, Animal - drug effects ; Binding, Competitive ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - metabolism ; Central nervous system ; Consensus Sequence ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Early Growth Response Protein 1 ; Fundamental and applied biological sciences. Psychology ; Immediate early gene ; Immediate-Early Proteins ; Kainic acid ; Kainic Acid - pharmacology ; Male ; N-Methylaspartate - pharmacology ; NGFI‐A ; NMDA ; Pentylenetetrazole ; Rats ; Rats, Wistar ; Tissue Distribution ; Transcription factor ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 1997-12, Vol.69 (6), p.2227-2237</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5567-695a77aa8d95931663234e3356aaac579b170a38a25c999a3a481c718d5b62903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.1997.69062227.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.1997.69062227.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2087831$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9375653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beckmann, Alison M.</creatorcontrib><creatorcontrib>Davidson, Mark S.</creatorcontrib><creatorcontrib>Goodenough, Sharon</creatorcontrib><creatorcontrib>Wilce, Peter A.</creatorcontrib><title>Differential Expression of Egr‐1‐Like DNA‐Binding Activities in the Naive Rat Brain and After Excitatory Stimulation</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Egr‐1 and related proteins are inducible transcription factors within the brain recognizing the same consensus DNA sequence. Three Egr DNA‐binding activities were observed in regions of the naive rat brain. Egr‐1 was present in all brain regions examined. Bands composed, at least in part, of Egr‐2 and Egr‐3 were present in different relative amounts in the cerebral cortex, striatum, hippocampus, thalamus, and midbrain. All had similar affinity and specificity for the Egr consensus DNA recognition sequence. Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr‐1 and Egr‐2/3 DNA‐binding activities in the cerebral cortex, hippocampus, and cerebellum. All convulsants induced Egr‐1 and Egr‐2 immunoreactivity in the cerebral cortex and hippocampus. These data indicate that the members of the Egr family are regulated at different levels and may interact at promoters containing the Egr consensus sequence to fine tune a program of gene expression resulting from excitatory stimuli.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Binding, Competitive</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Consensus Sequence</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Early Growth Response Protein 1</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immediate early gene</subject><subject>Immediate-Early Proteins</subject><subject>Kainic acid</subject><subject>Kainic Acid - pharmacology</subject><subject>Male</subject><subject>N-Methylaspartate - pharmacology</subject><subject>NGFI‐A</subject><subject>NMDA</subject><subject>Pentylenetetrazole</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tissue Distribution</subject><subject>Transcription factor</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkctuEzEUhi0EKqHwCEiWQOxm8GVsj8UqTVKgioLEZW2deDzFYTITbKckXfEIPGOfhBklzbbqwvLl_845lj6E3lCSU1LI96ucFopmBRU6p1qrXGoiGWMq3z1Bo1P2FI0IYSzjpGDP0YsYV4RQWUh6hs40V0IKPkK3U1_XLrg2eWjwbLcJLkbftbir8ew63P39R_s1978cni7G_fHCt5Vvr_HYJn_jk3cR-xannw4vwN84_BUSvgjQv0Fb4XGdXOjbWp8gdWGPvyW_3jaQ-hEv0bMamuheHfdz9ONy9n3yKZt_-fh5Mp5nVgipMqkFKAVQVlpoTqXkjBeOcyEBwAqll1QR4CUwYbXWwKEoqVW0rMRSMk34OXp36LsJ3e-ti8msfbSuaaB13TYapQsmlOAPglRy3bMD-OEA2tDFGFxtNsGvIewNJWZQZFZm0GAGDWZQZO4VmV1f_fo4Zrtcu-pUe3TS52-POUQLTR2gtT6eMEZKVXLaY9MD9sc3bv-YH5irxeT-xv8Dg0uvvQ</recordid><startdate>199712</startdate><enddate>199712</enddate><creator>Beckmann, Alison M.</creator><creator>Davidson, Mark S.</creator><creator>Goodenough, Sharon</creator><creator>Wilce, Peter A.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199712</creationdate><title>Differential Expression of Egr‐1‐Like DNA‐Binding Activities in the Naive Rat Brain and After Excitatory Stimulation</title><author>Beckmann, Alison M. ; Davidson, Mark S. ; Goodenough, Sharon ; Wilce, Peter A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5567-695a77aa8d95931663234e3356aaac579b170a38a25c999a3a481c718d5b62903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Binding, Competitive</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Central nervous system</topic><topic>Consensus Sequence</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Early Growth Response Protein 1</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immediate early gene</topic><topic>Immediate-Early Proteins</topic><topic>Kainic acid</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>N-Methylaspartate - pharmacology</topic><topic>NGFI‐A</topic><topic>NMDA</topic><topic>Pentylenetetrazole</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tissue Distribution</topic><topic>Transcription factor</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beckmann, Alison M.</creatorcontrib><creatorcontrib>Davidson, Mark S.</creatorcontrib><creatorcontrib>Goodenough, Sharon</creatorcontrib><creatorcontrib>Wilce, Peter A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beckmann, Alison M.</au><au>Davidson, Mark S.</au><au>Goodenough, Sharon</au><au>Wilce, Peter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Expression of Egr‐1‐Like DNA‐Binding Activities in the Naive Rat Brain and After Excitatory Stimulation</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1997-12</date><risdate>1997</risdate><volume>69</volume><issue>6</issue><spage>2227</spage><epage>2237</epage><pages>2227-2237</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Egr‐1 and related proteins are inducible transcription factors within the brain recognizing the same consensus DNA sequence. Three Egr DNA‐binding activities were observed in regions of the naive rat brain. Egr‐1 was present in all brain regions examined. Bands composed, at least in part, of Egr‐2 and Egr‐3 were present in different relative amounts in the cerebral cortex, striatum, hippocampus, thalamus, and midbrain. All had similar affinity and specificity for the Egr consensus DNA recognition sequence. Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr‐1 and Egr‐2/3 DNA‐binding activities in the cerebral cortex, hippocampus, and cerebellum. All convulsants induced Egr‐1 and Egr‐2 immunoreactivity in the cerebral cortex and hippocampus. These data indicate that the members of the Egr family are regulated at different levels and may interact at promoters containing the Egr consensus sequence to fine tune a program of gene expression resulting from excitatory stimuli.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9375653</pmid><doi>10.1046/j.1471-4159.1997.69062227.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Behavior, Animal - drug effects Binding, Competitive Biochemistry and metabolism Biological and medical sciences Brain - metabolism Central nervous system Consensus Sequence DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early Growth Response Protein 1 Fundamental and applied biological sciences. Psychology Immediate early gene Immediate-Early Proteins Kainic acid Kainic Acid - pharmacology Male N-Methylaspartate - pharmacology NGFI‐A NMDA Pentylenetetrazole Rats Rats, Wistar Tissue Distribution Transcription factor Transcription Factors - genetics Transcription Factors - metabolism Vertebrates: nervous system and sense organs |
| title | Differential Expression of Egr‐1‐Like DNA‐Binding Activities in the Naive Rat Brain and After Excitatory Stimulation |
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