Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression

Thyroid hormones influence growth and differentiation of bone cells. In vivo and in vitro data indicate their importance for development and maintenance of the skeleton. Triiodothyronine (T3) inhibits proliferation and accelerates differentiation of osteoblasts. We studied the regulatory effect of T...

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Veröffentlicht in:	Calcified tissue international 1997-11, Vol.61 (5), p.404-411
Hauptverfasser:	Varga, F, Rumpler, M, Luegmayr, E, Fratzl-Zelman, N, Glantschnig, H, Klaushofer, K
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - drug effects Alkaline Phosphatase - analysis Animals Cell Differentiation - drug effects Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Genes, fos - genetics Genes, jun - genetics Histones - antagonists & inhibitors Mice Osteoblasts - drug effects Osteocalcin - biosynthesis Osteocalcin - genetics Phenotype RNA, Messenger - biosynthesis RNA, Messenger - genetics Triiodothyronine - pharmacology
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