Intracellular metabolism of 3′-azido-3′-deoxythymidine (AZT): A nuclear magnetic resonance study on T-lymphoblastoid cell lines with different resistance to AZT

This paper reports the results of 1P and 1H nuclear magnetic resonance (NMR) studies on the uptake and phosphorylation of 3′-azido-3′-deoxythymidine (AZT) in the human CD4 + T-lymphoblastoid cell line CCRF-CEM (GEM-1.3) and in its AZT-resistant cell variant MT-500, isolated by prolonged culturing of...

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Veröffentlicht in:	Biochemical pharmacology 1997-11, Vol.54 (9), p.979-990
Hauptverfasser:	Di Vito, Massimo, Bozzi, Argante, Ferretti, Amalia, Cianfriglia, Maurizio, Barca, Stefano, Signoretti, Claudia, Lenti, Luisa, d'Agostino, Federica, Strom, Roberto, Podo, Franca
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - metabolism Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents AZT AZT resistance Biological and medical sciences Cell Line Humans lymphoid cells Magnetic Resonance Spectroscopy MDR Medical sciences NMR Pharmacology. Drug treatments Phosphorylation pyrimidine 5′-nucleotidase T-Lymphocytes - metabolism thymidine kinase Thymidine Kinase - genetics Zidovudine - metabolism
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