Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats
The purpose of the present study was to characterize possible effects of dietary-induced plasma lipid elevations on the development of arterial lesions in spontaneously hypertensive rats (SHR) and to reveal any influence of treatment with metoprolol on these parameters. Metoprolol treatment caused a...
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| Veröffentlicht in: | Atherosclerosis 1989-12, Vol.80 (2), p.135-142 |
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| creator | Östlund-Lindgvist, A.-M. Eklund, A. Sjöblom, L. Jonsson, L. |
| description | The purpose of the present study was to characterize possible effects of dietary-induced plasma lipid elevations on the development of arterial lesions in spontaneously hypertensive rats (SHR) and to reveal any influence of treatment with metoprolol on these parameters. Metoprolol treatment caused an 8% decrease in heart rate and a 13% decrease in blood pressure and led to a rise in plasma triglycerides, 24%, 17% and 34% after 1, 3 and 6 months of metoprolol treatment, respectively. However, no effect on plasma triglycerides was observed after 9 months of metoprolol treatment while a reduced cholesterolemic response was observed. Intimal proliferations containing accumulations of lipids were observed in small intramural branches of coronary arteries (> 100 μm in 11 of 31 control rats fed the atherogenic diet for 9 months. In contrast, similar changes were observed in only 1 of 34 metoprolol-treated rats fed an otherwise identical diet. The corresponding figures for the frequency of lipid containing intimal plaques in aorta were
6
19
in controls and
2
24
in the metoprolol-treated group. |
| doi_str_mv | 10.1016/0021-9150(89)90021-X |
| format | Article |
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6
19
in controls and
2
24
in the metoprolol-treated group.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/0021-9150(89)90021-X</identifier><identifier>PMID: 2610725</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Animals ; Aorta ; Aorta - pathology ; Arterial hypertension. Arterial hypotension ; Arteriosclerosis - prevention & control ; Atherosclerosis ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Coronary arteries ; Coronary Vessels - pathology ; Diet, Atherogenic ; Hypertension - drug therapy ; Hypertension - metabolism ; Lipids ; Lipids - blood ; Male ; Medical sciences ; Metoprolol ; Metoprolol - therapeutic use ; Rats ; Rats, Inbred SHR ; Spontaneously hypertensive rats ; Time Factors</subject><ispartof>Atherosclerosis, 1989-12, Vol.80 (2), p.135-142</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-935edd8599ac5e1ad05af3e578210b1becf9ff8177f4689955395495ebcd0c223</citedby><cites>FETCH-LOGICAL-c452t-935edd8599ac5e1ad05af3e578210b1becf9ff8177f4689955395495ebcd0c223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0021-9150(89)90021-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6656703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2610725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Östlund-Lindgvist, A.-M.</creatorcontrib><creatorcontrib>Eklund, A.</creatorcontrib><creatorcontrib>Sjöblom, L.</creatorcontrib><creatorcontrib>Jonsson, L.</creatorcontrib><title>Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>The purpose of the present study was to characterize possible effects of dietary-induced plasma lipid elevations on the development of arterial lesions in spontaneously hypertensive rats (SHR) and to reveal any influence of treatment with metoprolol on these parameters. Metoprolol treatment caused an 8% decrease in heart rate and a 13% decrease in blood pressure and led to a rise in plasma triglycerides, 24%, 17% and 34% after 1, 3 and 6 months of metoprolol treatment, respectively. However, no effect on plasma triglycerides was observed after 9 months of metoprolol treatment while a reduced cholesterolemic response was observed. Intimal proliferations containing accumulations of lipids were observed in small intramural branches of coronary arteries (> 100 μm in 11 of 31 control rats fed the atherogenic diet for 9 months. In contrast, similar changes were observed in only 1 of 34 metoprolol-treated rats fed an otherwise identical diet. The corresponding figures for the frequency of lipid containing intimal plaques in aorta were
6
19
in controls and
2
24
in the metoprolol-treated group.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - pathology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Arteriosclerosis - prevention & control</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Coronary arteries</subject><subject>Coronary Vessels - pathology</subject><subject>Diet, Atherogenic</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - metabolism</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metoprolol</subject><subject>Metoprolol - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Spontaneously hypertensive rats</subject><subject>Time Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rHSEUhqU0JLdp_0EDLkJpFtOqM87oJlBC2gQC3bSQnXj1SC2OTtQbuP--3g_usquDnOc9nPOI0EdKvlBCx6-EMNpJyslnIW_k_vX8Bq2omGRHBzG8RasTcoHelfKXEDJMVJyjczZSMjG-QvHeOTAVJ4dnqGnJKaSAU8RL0GXWOPjF24J1tFjnCtnrgH2sfm5138MWllR89S3jIy5LilVHSJsStvjPdoGWisW_As66lvfozOlQ4MOxXqLf3-9_3T10Tz9_PN59e-rMwFntZM_BWsGl1IYD1ZZw7Xrgk2CUrOkajJPOCTpNbhiFlJz3kg-Sw9pYYhjrL9Gnw9x20MsGSlWzLwZCOKymJjkwJnvRwOEAmpxKyeDUkttxeasoUTvNaudQ7RwqIdVes3pusavj_M16BnsKHb22_vWxr4vRwWUdjS8nbBz5OJG-YbcHDJqLVw9ZFeMhGrA-t19RNvn_7_EPg96bRQ</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Östlund-Lindgvist, A.-M.</creator><creator>Eklund, A.</creator><creator>Sjöblom, L.</creator><creator>Jonsson, L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891201</creationdate><title>Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats</title><author>Östlund-Lindgvist, A.-M. ; Eklund, A. ; Sjöblom, L. ; Jonsson, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-935edd8599ac5e1ad05af3e578210b1becf9ff8177f4689955395495ebcd0c223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - pathology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Arteriosclerosis - prevention & control</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Coronary arteries</topic><topic>Coronary Vessels - pathology</topic><topic>Diet, Atherogenic</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - metabolism</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metoprolol</topic><topic>Metoprolol - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Spontaneously hypertensive rats</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Östlund-Lindgvist, A.-M.</creatorcontrib><creatorcontrib>Eklund, A.</creatorcontrib><creatorcontrib>Sjöblom, L.</creatorcontrib><creatorcontrib>Jonsson, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Östlund-Lindgvist, A.-M.</au><au>Eklund, A.</au><au>Sjöblom, L.</au><au>Jonsson, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>80</volume><issue>2</issue><spage>135</spage><epage>142</epage><pages>135-142</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>The purpose of the present study was to characterize possible effects of dietary-induced plasma lipid elevations on the development of arterial lesions in spontaneously hypertensive rats (SHR) and to reveal any influence of treatment with metoprolol on these parameters. Metoprolol treatment caused an 8% decrease in heart rate and a 13% decrease in blood pressure and led to a rise in plasma triglycerides, 24%, 17% and 34% after 1, 3 and 6 months of metoprolol treatment, respectively. However, no effect on plasma triglycerides was observed after 9 months of metoprolol treatment while a reduced cholesterolemic response was observed. Intimal proliferations containing accumulations of lipids were observed in small intramural branches of coronary arteries (> 100 μm in 11 of 31 control rats fed the atherogenic diet for 9 months. In contrast, similar changes were observed in only 1 of 34 metoprolol-treated rats fed an otherwise identical diet. The corresponding figures for the frequency of lipid containing intimal plaques in aorta were
6
19
in controls and
2
24
in the metoprolol-treated group.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>2610725</pmid><doi>10.1016/0021-9150(89)90021-X</doi><tpages>8</tpages></addata></record> |
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| ispartof | Atherosclerosis, 1989-12, Vol.80 (2), p.135-142 |
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| language | eng |
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| subjects | Animals Aorta Aorta - pathology Arterial hypertension. Arterial hypotension Arteriosclerosis - prevention & control Atherosclerosis Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary arteries Coronary Vessels - pathology Diet, Atherogenic Hypertension - drug therapy Hypertension - metabolism Lipids Lipids - blood Male Medical sciences Metoprolol Metoprolol - therapeutic use Rats Rats, Inbred SHR Spontaneously hypertensive rats Time Factors |
| title | Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats |
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