Synthesis and properties of the box 9R and 9R' sequences of Tetrahymena rRNA

Synthesis and properties of the box 9R and 9R' sequences of Tetrahymena rRNA

The chloroethoxyethyl (CEE) group is completely stable under the acidic conditions required to remove the 5'-protecting groups in the oligoribonucleotide synthesis, but can be cleaved under the similar condition to that of the tetrahydropyranyl (THP) group in region of pH 2-3. The oligoribonucl...

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Veröffentlicht in:Nucleic acids symposium series (1979) 1989 (21), p.81-82
Hauptverfasser: Yamakage, S, Sakatsume, O, Takaku, H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Oligoribonucleotides - chemical synthesis
RNA, Ribosomal - chemical synthesis
Tetrahymena - genetics
Uridine - analogs & derivatives
Uridine - chemical synthesis
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Zusammenfassung:The chloroethoxyethyl (CEE) group is completely stable under the acidic conditions required to remove the 5'-protecting groups in the oligoribonucleotide synthesis, but can be cleaved under the similar condition to that of the tetrahydropyranyl (THP) group in region of pH 2-3. The oligoribonucleotides were synthesized by the phosphoramidite method on solid supports.
ISSN:0261-3166