Simplified Technetium-99m-EC Clearance in Adults from a Single Plasma Sample
Technetium-99m-EC has recently been introduced as an alternative renal tubular agent to 131I-ortho iodohippurate (OIH). It has been shown that 99mTc-EC clearance shows strong correlation with OIH clearance and it is possible to estimate effective renal plasma flow. In routine clinical studies, it is...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1997-11, Vol.38 (11), p.1784-1786 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Kabasakal, Levent Yapar, A. Fuat Ozker, Kutlan Alkan, Ebru Atay, Saadet Ozcelik, Nihat Onsel, cetin |
| description | Technetium-99m-EC has recently been introduced as an alternative renal tubular agent to 131I-ortho iodohippurate (OIH). It has been shown that 99mTc-EC clearance shows strong correlation with OIH clearance and it is possible to estimate effective renal plasma flow. In routine clinical studies, it is practical to use one or two plasma sample methods instead of multiple plasma samples for clearance determination. An attempt was made to determine 99mTc-EC clearance with one sample method.
Data from 72 subjects were collected. To increase the range of renal function, two anuric hemodialysis patients were also included. Clearances were determined by the open two-compartment model.
The clearance range was 12 ml/min to 660 ml/min with a mean of 275 +/- 117 ml/min. Analysis of correlation was made by Tauxe's method. The least standard error of estimation (s.e.e. = 32.71 ml/min) and the best correlation (r = 0.97) between the theoretical volume distribution and the clearance estimations were obtained from the 54-min plasma sample.
This study suggests that EC clearance could be determined by a simplified single-sample method with an acceptable s.e.e. |
| format | Article |
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Data from 72 subjects were collected. To increase the range of renal function, two anuric hemodialysis patients were also included. Clearances were determined by the open two-compartment model.
The clearance range was 12 ml/min to 660 ml/min with a mean of 275 +/- 117 ml/min. Analysis of correlation was made by Tauxe's method. The least standard error of estimation (s.e.e. = 32.71 ml/min) and the best correlation (r = 0.97) between the theoretical volume distribution and the clearance estimations were obtained from the 54-min plasma sample.
This study suggests that EC clearance could be determined by a simplified single-sample method with an acceptable s.e.e.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 9374355</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Adult ; Biological and medical sciences ; Cysteine - analogs & derivatives ; Cysteine - blood ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney - diagnostic imaging ; Kidney Transplantation - diagnostic imaging ; Male ; Medical sciences ; Middle Aged ; Organotechnetium Compounds - blood ; Radionuclide Imaging ; Radionuclide investigations ; Radiopharmaceuticals - blood ; Renal Insufficiency - diagnostic imaging ; Renal Plasma Flow, Effective ; Time Factors ; Urinary system</subject><ispartof>The Journal of nuclear medicine (1978), 1997-11, Vol.38 (11), p.1784-1786</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Nov 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2065373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9374355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabasakal, Levent</creatorcontrib><creatorcontrib>Yapar, A. Fuat</creatorcontrib><creatorcontrib>Ozker, Kutlan</creatorcontrib><creatorcontrib>Alkan, Ebru</creatorcontrib><creatorcontrib>Atay, Saadet</creatorcontrib><creatorcontrib>Ozcelik, Nihat</creatorcontrib><creatorcontrib>Onsel, cetin</creatorcontrib><title>Simplified Technetium-99m-EC Clearance in Adults from a Single Plasma Sample</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Technetium-99m-EC has recently been introduced as an alternative renal tubular agent to 131I-ortho iodohippurate (OIH). It has been shown that 99mTc-EC clearance shows strong correlation with OIH clearance and it is possible to estimate effective renal plasma flow. In routine clinical studies, it is practical to use one or two plasma sample methods instead of multiple plasma samples for clearance determination. An attempt was made to determine 99mTc-EC clearance with one sample method.
Data from 72 subjects were collected. To increase the range of renal function, two anuric hemodialysis patients were also included. Clearances were determined by the open two-compartment model.
The clearance range was 12 ml/min to 660 ml/min with a mean of 275 +/- 117 ml/min. Analysis of correlation was made by Tauxe's method. The least standard error of estimation (s.e.e. = 32.71 ml/min) and the best correlation (r = 0.97) between the theoretical volume distribution and the clearance estimations were obtained from the 54-min plasma sample.
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Fuat</au><au>Ozker, Kutlan</au><au>Alkan, Ebru</au><au>Atay, Saadet</au><au>Ozcelik, Nihat</au><au>Onsel, cetin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simplified Technetium-99m-EC Clearance in Adults from a Single Plasma Sample</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>38</volume><issue>11</issue><spage>1784</spage><epage>1786</epage><pages>1784-1786</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>Technetium-99m-EC has recently been introduced as an alternative renal tubular agent to 131I-ortho iodohippurate (OIH). It has been shown that 99mTc-EC clearance shows strong correlation with OIH clearance and it is possible to estimate effective renal plasma flow. In routine clinical studies, it is practical to use one or two plasma sample methods instead of multiple plasma samples for clearance determination. An attempt was made to determine 99mTc-EC clearance with one sample method.
Data from 72 subjects were collected. To increase the range of renal function, two anuric hemodialysis patients were also included. Clearances were determined by the open two-compartment model.
The clearance range was 12 ml/min to 660 ml/min with a mean of 275 +/- 117 ml/min. Analysis of correlation was made by Tauxe's method. The least standard error of estimation (s.e.e. = 32.71 ml/min) and the best correlation (r = 0.97) between the theoretical volume distribution and the clearance estimations were obtained from the 54-min plasma sample.
This study suggests that EC clearance could be determined by a simplified single-sample method with an acceptable s.e.e.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>9374355</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1997-11, Vol.38 (11), p.1784-1786 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Cysteine - analogs & derivatives Cysteine - blood Female Humans Investigative techniques, diagnostic techniques (general aspects) Kidney - diagnostic imaging Kidney Transplantation - diagnostic imaging Male Medical sciences Middle Aged Organotechnetium Compounds - blood Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals - blood Renal Insufficiency - diagnostic imaging Renal Plasma Flow, Effective Time Factors Urinary system |
| title | Simplified Technetium-99m-EC Clearance in Adults from a Single Plasma Sample |
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