Dynamic cardiomyoplasty: clinical follow-up at 12 years
OBJECTIVE: The purpose of this study is to evaluate the long-termo utcome of dynamic cardiomyoplasty. This surgical technique was conceived to assist the failing heart. The many proposed mechanisms of action of cardiomyoplasty are: (1) systolic assist; (2) limitation of ventricular dilation; (3) red...
Gespeichert in:
| Veröffentlicht in: | European journal of cardio-thoracic surgery 1997-10, Vol.12 (4), p.560-567 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 567 |
|---|---|
| container_issue | 4 |
| container_start_page | 560 |
| container_title | European journal of cardio-thoracic surgery |
| container_volume | 12 |
| creator | CHACHQUES, J. C MARINO, J.-P LAJOS, P ZEGDI, R D'ATTELLIS, N FORNES, P FABIANI, J.-N CARPENTIER, A |
| description | OBJECTIVE: The purpose of this study is to evaluate the long-termo utcome of dynamic cardiomyoplasty. This surgical technique was conceived to assist the failing heart. The many proposed mechanisms of action of cardiomyoplasty are: (1) systolic assist; (2) limitation of ventricular dilation; (3) reduction of ventricular wall stress (sparing effect); (4) ventricular remodeling with an active girdling effect; (5) angiogenesis;and (6) a neurohumoral effect. METHODS: We investigated 95 patients in our hospital undergoing this procedure due to severe chronic heart failure, refractory to optimal medical treatment. Patients had a mean age of 51 ± 12 years. The etiology of heart failure was ischemic 55%, idiopathic 34%, ventricular tumor 6%, and other 5%. The mean follow-up was 44 months. RESULTS: The mean New York Heart Association (NYHA) functional classi mproved postoperatively from 3.2 to 1.8. Average radioisotopic left ventricular (LV) ejection fraction increased from 17 ± 5 to 27 ± 4% (P< 0.05). Stroke volume index increased from 32 ± 7 to 43 ± 8 ml/beatper m2 (P < 0.05). The heart size remained stable over the long term. Following cardiomyoplasty, the number of hospitalizations due to congestive heart failure was reduced to 0.4 hospitalizations/patient per year (preoperative: 2.5, P < 0.05). Computed tomography scans showed at longterm a preserved latissimus dorsi muscle structure in 84% of patients. Survival probability at 7 years is 54%. Six patients underwent heart transplant after cardiomyoplasty (mean delay: 25 months), due to the natural evolution of their underlying heart disease. There were no specific technical difficulties. CONCLUSIONS: Clinically, this procedure reverses heart failure, improves functional class and ameliorates quality of life. The latissimus dorsi muscle histological structure is maintained atlong-term, when postoperative electrostimulation is performed, avoiding excessive stimulation. Cardiomyoplasty may delay or prevent the progressionof heart failure and the indication of cardiac transplantation. |
| doi_str_mv | 10.1016/S1010-7940(97)00214-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79419728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1016/S1010-7940(97)00214-5</oup_id><sourcerecordid>79419728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-9f2226600ad5a3a2dd9f7178f52421a687c5c0a90d12ea64e3cee535c43e9c993</originalsourceid><addsrcrecordid>eNptkMtKxDAUhoMo3h9B6EJEF9GTpGkad94VhhG8gLgJxzSFajutSYv27e1cHBDcJIHzffk5PyF7DI4ZsOTkcTiBKh3DoVZHAJzFVK6QTZYqQZWIX1aH9y-yQbZCeAeARHC1Tta1UCC03iTqsp9gVdjIos-KuurrpsTQ9qeRLYtJYbGM8ros6y_aNRG2EeNR79CHHbKWYxnc7uLeJs_XV08Xt3R0f3N3cTaiVnLRUp1zzpMEADOJAnmW6VwxleaSx5xhkiorLaCGjHGHSeyEdU4KaWPhtNVabJOD-b-Nrz87F1pTFcG6ssSJq7tghuWYVjwdQDkHra9D8C43jS8q9L1hYKaFmVlhUwGMVmZWmJGDt7cI6N4qly2tRUPDfH8xxzC0kXuc2CIsMQ5xqpNpPMyxumv-T6Z_kuk0mc6VIrTueymh_zCJEkqa25dXox7G48fzkTav4geHK46m</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79419728</pqid></control><display><type>article</type><title>Dynamic cardiomyoplasty: clinical follow-up at 12 years</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CHACHQUES, J. C ; MARINO, J.-P ; LAJOS, P ; ZEGDI, R ; D'ATTELLIS, N ; FORNES, P ; FABIANI, J.-N ; CARPENTIER, A</creator><creatorcontrib>CHACHQUES, J. C ; MARINO, J.-P ; LAJOS, P ; ZEGDI, R ; D'ATTELLIS, N ; FORNES, P ; FABIANI, J.-N ; CARPENTIER, A</creatorcontrib><description>OBJECTIVE: The purpose of this study is to evaluate the long-termo utcome of dynamic cardiomyoplasty. This surgical technique was conceived to assist the failing heart. The many proposed mechanisms of action of cardiomyoplasty are: (1) systolic assist; (2) limitation of ventricular dilation; (3) reduction of ventricular wall stress (sparing effect); (4) ventricular remodeling with an active girdling effect; (5) angiogenesis;and (6) a neurohumoral effect. METHODS: We investigated 95 patients in our hospital undergoing this procedure due to severe chronic heart failure, refractory to optimal medical treatment. Patients had a mean age of 51 ± 12 years. The etiology of heart failure was ischemic 55%, idiopathic 34%, ventricular tumor 6%, and other 5%. The mean follow-up was 44 months. RESULTS: The mean New York Heart Association (NYHA) functional classi mproved postoperatively from 3.2 to 1.8. Average radioisotopic left ventricular (LV) ejection fraction increased from 17 ± 5 to 27 ± 4% (P< 0.05). Stroke volume index increased from 32 ± 7 to 43 ± 8 ml/beatper m2 (P < 0.05). The heart size remained stable over the long term. Following cardiomyoplasty, the number of hospitalizations due to congestive heart failure was reduced to 0.4 hospitalizations/patient per year (preoperative: 2.5, P < 0.05). Computed tomography scans showed at longterm a preserved latissimus dorsi muscle structure in 84% of patients. Survival probability at 7 years is 54%. Six patients underwent heart transplant after cardiomyoplasty (mean delay: 25 months), due to the natural evolution of their underlying heart disease. There were no specific technical difficulties. CONCLUSIONS: Clinically, this procedure reverses heart failure, improves functional class and ameliorates quality of life. The latissimus dorsi muscle histological structure is maintained atlong-term, when postoperative electrostimulation is performed, avoiding excessive stimulation. Cardiomyoplasty may delay or prevent the progressionof heart failure and the indication of cardiac transplantation.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1016/S1010-7940(97)00214-5</identifier><identifier>PMID: 9370399</identifier><identifier>CODEN: EJCSE7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Science B.V</publisher><subject>Actuarial Analysis ; Biological and medical sciences ; Cardiomyoplasty - mortality ; Female ; Follow-Up Studies ; Heart Failure - mortality ; Heart Failure - surgery ; Heart Transplantation - statistics & numerical data ; Humans ; Male ; Medical sciences ; Middle Aged ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors ; Treatment Outcome</subject><ispartof>European journal of cardio-thoracic surgery, 1997-10, Vol.12 (4), p.560-567</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-9f2226600ad5a3a2dd9f7178f52421a687c5c0a90d12ea64e3cee535c43e9c993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2048968$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9370399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHACHQUES, J. C</creatorcontrib><creatorcontrib>MARINO, J.-P</creatorcontrib><creatorcontrib>LAJOS, P</creatorcontrib><creatorcontrib>ZEGDI, R</creatorcontrib><creatorcontrib>D'ATTELLIS, N</creatorcontrib><creatorcontrib>FORNES, P</creatorcontrib><creatorcontrib>FABIANI, J.-N</creatorcontrib><creatorcontrib>CARPENTIER, A</creatorcontrib><title>Dynamic cardiomyoplasty: clinical follow-up at 12 years</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><addtitle>Eur J Cardiothorac Surg</addtitle><description>OBJECTIVE: The purpose of this study is to evaluate the long-termo utcome of dynamic cardiomyoplasty. This surgical technique was conceived to assist the failing heart. The many proposed mechanisms of action of cardiomyoplasty are: (1) systolic assist; (2) limitation of ventricular dilation; (3) reduction of ventricular wall stress (sparing effect); (4) ventricular remodeling with an active girdling effect; (5) angiogenesis;and (6) a neurohumoral effect. METHODS: We investigated 95 patients in our hospital undergoing this procedure due to severe chronic heart failure, refractory to optimal medical treatment. Patients had a mean age of 51 ± 12 years. The etiology of heart failure was ischemic 55%, idiopathic 34%, ventricular tumor 6%, and other 5%. The mean follow-up was 44 months. RESULTS: The mean New York Heart Association (NYHA) functional classi mproved postoperatively from 3.2 to 1.8. Average radioisotopic left ventricular (LV) ejection fraction increased from 17 ± 5 to 27 ± 4% (P< 0.05). Stroke volume index increased from 32 ± 7 to 43 ± 8 ml/beatper m2 (P < 0.05). The heart size remained stable over the long term. Following cardiomyoplasty, the number of hospitalizations due to congestive heart failure was reduced to 0.4 hospitalizations/patient per year (preoperative: 2.5, P < 0.05). Computed tomography scans showed at longterm a preserved latissimus dorsi muscle structure in 84% of patients. Survival probability at 7 years is 54%. Six patients underwent heart transplant after cardiomyoplasty (mean delay: 25 months), due to the natural evolution of their underlying heart disease. There were no specific technical difficulties. CONCLUSIONS: Clinically, this procedure reverses heart failure, improves functional class and ameliorates quality of life. The latissimus dorsi muscle histological structure is maintained atlong-term, when postoperative electrostimulation is performed, avoiding excessive stimulation. Cardiomyoplasty may delay or prevent the progressionof heart failure and the indication of cardiac transplantation.</description><subject>Actuarial Analysis</subject><subject>Biological and medical sciences</subject><subject>Cardiomyoplasty - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - surgery</subject><subject>Heart Transplantation - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtKxDAUhoMo3h9B6EJEF9GTpGkad94VhhG8gLgJxzSFajutSYv27e1cHBDcJIHzffk5PyF7DI4ZsOTkcTiBKh3DoVZHAJzFVK6QTZYqQZWIX1aH9y-yQbZCeAeARHC1Tta1UCC03iTqsp9gVdjIos-KuurrpsTQ9qeRLYtJYbGM8ros6y_aNRG2EeNR79CHHbKWYxnc7uLeJs_XV08Xt3R0f3N3cTaiVnLRUp1zzpMEADOJAnmW6VwxleaSx5xhkiorLaCGjHGHSeyEdU4KaWPhtNVabJOD-b-Nrz87F1pTFcG6ssSJq7tghuWYVjwdQDkHra9D8C43jS8q9L1hYKaFmVlhUwGMVmZWmJGDt7cI6N4qly2tRUPDfH8xxzC0kXuc2CIsMQ5xqpNpPMyxumv-T6Z_kuk0mc6VIrTueymh_zCJEkqa25dXox7G48fzkTav4geHK46m</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>CHACHQUES, J. C</creator><creator>MARINO, J.-P</creator><creator>LAJOS, P</creator><creator>ZEGDI, R</creator><creator>D'ATTELLIS, N</creator><creator>FORNES, P</creator><creator>FABIANI, J.-N</creator><creator>CARPENTIER, A</creator><general>Elsevier Science B.V</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Dynamic cardiomyoplasty: clinical follow-up at 12 years</title><author>CHACHQUES, J. C ; MARINO, J.-P ; LAJOS, P ; ZEGDI, R ; D'ATTELLIS, N ; FORNES, P ; FABIANI, J.-N ; CARPENTIER, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-9f2226600ad5a3a2dd9f7178f52421a687c5c0a90d12ea64e3cee535c43e9c993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Actuarial Analysis</topic><topic>Biological and medical sciences</topic><topic>Cardiomyoplasty - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - surgery</topic><topic>Heart Transplantation - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHACHQUES, J. C</creatorcontrib><creatorcontrib>MARINO, J.-P</creatorcontrib><creatorcontrib>LAJOS, P</creatorcontrib><creatorcontrib>ZEGDI, R</creatorcontrib><creatorcontrib>D'ATTELLIS, N</creatorcontrib><creatorcontrib>FORNES, P</creatorcontrib><creatorcontrib>FABIANI, J.-N</creatorcontrib><creatorcontrib>CARPENTIER, A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHACHQUES, J. C</au><au>MARINO, J.-P</au><au>LAJOS, P</au><au>ZEGDI, R</au><au>D'ATTELLIS, N</au><au>FORNES, P</au><au>FABIANI, J.-N</au><au>CARPENTIER, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic cardiomyoplasty: clinical follow-up at 12 years</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><stitle>Eur J Cardiothorac Surg</stitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>12</volume><issue>4</issue><spage>560</spage><epage>567</epage><pages>560-567</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><coden>EJCSE7</coden><abstract>OBJECTIVE: The purpose of this study is to evaluate the long-termo utcome of dynamic cardiomyoplasty. This surgical technique was conceived to assist the failing heart. The many proposed mechanisms of action of cardiomyoplasty are: (1) systolic assist; (2) limitation of ventricular dilation; (3) reduction of ventricular wall stress (sparing effect); (4) ventricular remodeling with an active girdling effect; (5) angiogenesis;and (6) a neurohumoral effect. METHODS: We investigated 95 patients in our hospital undergoing this procedure due to severe chronic heart failure, refractory to optimal medical treatment. Patients had a mean age of 51 ± 12 years. The etiology of heart failure was ischemic 55%, idiopathic 34%, ventricular tumor 6%, and other 5%. The mean follow-up was 44 months. RESULTS: The mean New York Heart Association (NYHA) functional classi mproved postoperatively from 3.2 to 1.8. Average radioisotopic left ventricular (LV) ejection fraction increased from 17 ± 5 to 27 ± 4% (P< 0.05). Stroke volume index increased from 32 ± 7 to 43 ± 8 ml/beatper m2 (P < 0.05). The heart size remained stable over the long term. Following cardiomyoplasty, the number of hospitalizations due to congestive heart failure was reduced to 0.4 hospitalizations/patient per year (preoperative: 2.5, P < 0.05). Computed tomography scans showed at longterm a preserved latissimus dorsi muscle structure in 84% of patients. Survival probability at 7 years is 54%. Six patients underwent heart transplant after cardiomyoplasty (mean delay: 25 months), due to the natural evolution of their underlying heart disease. There were no specific technical difficulties. CONCLUSIONS: Clinically, this procedure reverses heart failure, improves functional class and ameliorates quality of life. The latissimus dorsi muscle histological structure is maintained atlong-term, when postoperative electrostimulation is performed, avoiding excessive stimulation. Cardiomyoplasty may delay or prevent the progressionof heart failure and the indication of cardiac transplantation.</abstract><cop>Amsterdam</cop><pub>Elsevier Science B.V</pub><pmid>9370399</pmid><doi>10.1016/S1010-7940(97)00214-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-7940 |
| ispartof | European journal of cardio-thoracic surgery, 1997-10, Vol.12 (4), p.560-567 |
| issn | 1010-7940 1873-734X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79419728 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Actuarial Analysis Biological and medical sciences Cardiomyoplasty - mortality Female Follow-Up Studies Heart Failure - mortality Heart Failure - surgery Heart Transplantation - statistics & numerical data Humans Male Medical sciences Middle Aged Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors Treatment Outcome |
| title | Dynamic cardiomyoplasty: clinical follow-up at 12 years |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T05%3A39%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20cardiomyoplasty:%20clinical%20follow-up%20at%2012%20years&rft.jtitle=European%20journal%20of%20cardio-thoracic%20surgery&rft.au=CHACHQUES,%20J.%20C&rft.date=1997-10-01&rft.volume=12&rft.issue=4&rft.spage=560&rft.epage=567&rft.pages=560-567&rft.issn=1010-7940&rft.eissn=1873-734X&rft.coden=EJCSE7&rft_id=info:doi/10.1016/S1010-7940(97)00214-5&rft_dat=%3Cproquest_cross%3E79419728%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79419728&rft_id=info:pmid/9370399&rft_oup_id=10.1016/S1010-7940(97)00214-5&rfr_iscdi=true |