Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-( p-nitrobenzyl)- trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C-Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1997-10, Vol.5 (10), p.1925-1934
Hauptverfasser:	Wu, C., Kobayashi, H., Sun, B., Yoo, T.M., Paik, C.H., Gansow, O.A., Carrasquillo, J.A., Pastan, I., Brechbiel, M.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chelating Agents - chemical synthesis Chelating Agents - chemistry Chelating Agents - pharmacokinetics Drug Stability Humans Isothiocyanates - chemical synthesis Isothiocyanates - chemistry Ligands Mice Pentetic Acid - analogs & derivatives Pentetic Acid - chemical synthesis Pentetic Acid - chemistry Stereoisomerism Structure-Activity Relationship Tissue Distribution Yttrium - chemistry
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