Early events associated with experimental infection of the murine lung with Rhodococcus equi
Pneumonia due to Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs,...
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| Veröffentlicht in: | Journal of comparative pathology 1989-11, Vol.101 (4), p.411-420 |
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| container_title | Journal of comparative pathology |
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| creator | Bowles, Pamela M. Woolcock, J.B. Mutimer, M.D. |
| description | Pneumonia due to
Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs, events in the host-parasite interaction were followed until day 7. Early bacterial clearance from the lung was dose-dependent but was not sustained. A proportion of the inoculated
R. equi was susceptible to the early nonspecific phagocytic cell response, and the contribution of neutrophils to bacterial clearance appeared largely limited to the first 24 hours. A substantial fraction of the organisms survived in the alveoli, probably within macrophages. The contribution phagocytes make to resistance against
R. equi is similar to that which prevails in infection with
Listeria monocytogenes. |
| doi_str_mv | 10.1016/0021-9975(89)90024-8 |
| format | Article |
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Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs, events in the host-parasite interaction were followed until day 7. Early bacterial clearance from the lung was dose-dependent but was not sustained. A proportion of the inoculated
R. equi was susceptible to the early nonspecific phagocytic cell response, and the contribution of neutrophils to bacterial clearance appeared largely limited to the first 24 hours. A substantial fraction of the organisms survived in the alveoli, probably within macrophages. The contribution phagocytes make to resistance against
R. equi is similar to that which prevails in infection with
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Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs, events in the host-parasite interaction were followed until day 7. Early bacterial clearance from the lung was dose-dependent but was not sustained. A proportion of the inoculated
R. equi was susceptible to the early nonspecific phagocytic cell response, and the contribution of neutrophils to bacterial clearance appeared largely limited to the first 24 hours. A substantial fraction of the organisms survived in the alveoli, probably within macrophages. The contribution phagocytes make to resistance against
R. equi is similar to that which prevails in infection with
Listeria monocytogenes.</description><subject>Actinomycetales Infections - immunology</subject><subject>Actinomycetales Infections - microbiology</subject><subject>Actinomycetales Infections - pathology</subject><subject>Animals</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - pathology</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Infectious diseases</subject><subject>Leukocyte Count</subject><subject>Lung - immunology</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - microbiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - microbiology</subject><subject>Phagocytosis</subject><subject>Pneumonia - immunology</subject><subject>Pneumonia - microbiology</subject><subject>Pneumonia - pathology</subject><subject>Rhodococcus - isolation & purification</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVpSBy3_6AFHUpJDtuOtB-SLoFi8gWBQkhvBaFIs7XCeuVIu0787yN3jY85DZr3mWH0EPKFwQ8GrPkJwFmhlKjPpDpX-VUV8gOZsbrkRcm4-khmB-SEnKb0BABS1vyYHPMGBLByRv5emthtKW6wHxI1KQXrzYCOvvhhSfF1jdGvcmY66vsW7eBDT0NLhyXS1Rh9j7Qb-38Tfr8MLthg7ZgoPo_-EzlqTZfw877OyZ-ry4fFTXH3-_p28euusKVshsK4Brkw_NGAYOjKtgXTcmfROJW7gjelqgCsqkVlpKqkcFxyBhKhriRgOSffp73rGJ5HTINe-WSx60yPYUxaqIpJBjyD1QTaGFKK2Op1_p6JW81A76TqnTG9M6al0v-lapnHvu73j48rdIehvcWcf9vnJlnTtdH01qcD1jSyZkJk7GLCMLvYeIw6WY-9RedjNqtd8O_f8QYsH5Os</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Bowles, Pamela M.</creator><creator>Woolcock, J.B.</creator><creator>Mutimer, M.D.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Early events associated with experimental infection of the murine lung with Rhodococcus equi</title><author>Bowles, Pamela M. ; Woolcock, J.B. ; Mutimer, M.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ad6e27a2ba071ed3ff0af2dcead9a2b72639400c9574a89487d282108e05480e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Actinomycetales Infections - immunology</topic><topic>Actinomycetales Infections - microbiology</topic><topic>Actinomycetales Infections - pathology</topic><topic>Animals</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - pathology</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Infectious diseases</topic><topic>Leukocyte Count</topic><topic>Lung - immunology</topic><topic>Lung - microbiology</topic><topic>Lung - pathology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - microbiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - microbiology</topic><topic>Phagocytosis</topic><topic>Pneumonia - immunology</topic><topic>Pneumonia - microbiology</topic><topic>Pneumonia - pathology</topic><topic>Rhodococcus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowles, Pamela M.</creatorcontrib><creatorcontrib>Woolcock, J.B.</creatorcontrib><creatorcontrib>Mutimer, M.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowles, Pamela M.</au><au>Woolcock, J.B.</au><au>Mutimer, M.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early events associated with experimental infection of the murine lung with Rhodococcus equi</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>101</volume><issue>4</issue><spage>411</spage><epage>420</epage><pages>411-420</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><coden>JCVPAR</coden><abstract>Pneumonia due to
Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs, events in the host-parasite interaction were followed until day 7. Early bacterial clearance from the lung was dose-dependent but was not sustained. A proportion of the inoculated
R. equi was susceptible to the early nonspecific phagocytic cell response, and the contribution of neutrophils to bacterial clearance appeared largely limited to the first 24 hours. A substantial fraction of the organisms survived in the alveoli, probably within macrophages. The contribution phagocytes make to resistance against
R. equi is similar to that which prevails in infection with
Listeria monocytogenes.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>2607013</pmid><doi>10.1016/0021-9975(89)90024-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of comparative pathology, 1989-11, Vol.101 (4), p.411-420 |
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| subjects | Actinomycetales Infections - immunology Actinomycetales Infections - microbiology Actinomycetales Infections - pathology Animals Bacterial diseases Biological and medical sciences Bronchoalveolar Lavage Fluid - pathology Experimental bacterial diseases and models Female Infectious diseases Leukocyte Count Lung - immunology Lung - microbiology Lung - pathology Macrophages - immunology Macrophages - microbiology Medical sciences Mice Neutrophils - immunology Neutrophils - microbiology Phagocytosis Pneumonia - immunology Pneumonia - microbiology Pneumonia - pathology Rhodococcus - isolation & purification |
| title | Early events associated with experimental infection of the murine lung with Rhodococcus equi |
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