Adrenoceptors in Raynaud’s Disease
Experiments were designed to study adrenoceptor function in subjects with Raynaud’s disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepi...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1989-12, Vol.14 (6), p.881-885 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Lindblad, Lars Erik Ekenvall, Lena Etzell, Britt-Marie Bevegård, Sture |
| description | Experiments were designed to study adrenoceptor function in subjects with Raynaud’s disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepinephrine (NE, stimulating α1-and α2-adrenoceptors), phenylephrine (stimulating α1-adrenoceptors), and B-HT 933 (stimulating α2-adrenoceptors) were studied in 12 women with Raynaud’s disease and in 12 healthy controls. Controls and cases showed a similar consistent vasoconstriction to NE and B-HT 933. All control subjects showed a vasoconstriction to phenylephrine. In contrast, the Raynaud subjects demonstrated a weaker vasoconstriction or even a vasodilation, especially to low concentrations of the drug. After blockade of the α1-adrenoceptors by doxazosin in the controls, phenylephrine mimicked the reaction in Raynaud subjects. β-Adrenoceptor agonists (isoprenaline and terbutaline) had no effect on finger blood flow in the examined finger skin area in either control or Raynaud subjects. We suggest that Raynaud’s disease is characterized by a defect in α1-adrenoceptor function. |
| doi_str_mv | 10.1097/00005344-198912000-00014 |
| format | Article |
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After blockade of the α1-adrenoceptors by doxazosin in the controls, phenylephrine mimicked the reaction in Raynaud subjects. β-Adrenoceptor agonists (isoprenaline and terbutaline) had no effect on finger blood flow in the examined finger skin area in either control or Raynaud subjects. We suggest that Raynaud’s disease is characterized by a defect in α1-adrenoceptor function.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198912000-00014</identifier><identifier>PMID: 2481777</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Adult ; Azepines - pharmacology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Doxazosin ; Female ; Fingers - blood supply ; Humans ; Isoproterenol - pharmacology ; Male ; Medical sciences ; Middle Aged ; norepinephrine ; Norepinephrine - pharmacology ; phenylephrine ; Prazosin - analogs & derivatives ; Prazosin - pharmacology ; Raynaud Disease - physiopathology ; Raynaud's disease ; Receptors, Adrenergic - drug effects ; Receptors, Adrenergic - physiology ; Regional Blood Flow - drug effects ; Skin - blood supply</subject><ispartof>Journal of cardiovascular pharmacology, 1989-12, Vol.14 (6), p.881-885</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4654-96b3a7a41a44bda061123860b94864a80fb49ada2df5ae03b83f6330bec504f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00005344-198912000-00014$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198912000-00014$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6746828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2481777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindblad, Lars Erik</creatorcontrib><creatorcontrib>Ekenvall, Lena</creatorcontrib><creatorcontrib>Etzell, Britt-Marie</creatorcontrib><creatorcontrib>Bevegård, Sture</creatorcontrib><title>Adrenoceptors in Raynaud’s Disease</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Experiments were designed to study adrenoceptor function in subjects with Raynaud’s disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepinephrine (NE, stimulating α1-and α2-adrenoceptors), phenylephrine (stimulating α1-adrenoceptors), and B-HT 933 (stimulating α2-adrenoceptors) were studied in 12 women with Raynaud’s disease and in 12 healthy controls. Controls and cases showed a similar consistent vasoconstriction to NE and B-HT 933. All control subjects showed a vasoconstriction to phenylephrine. In contrast, the Raynaud subjects demonstrated a weaker vasoconstriction or even a vasodilation, especially to low concentrations of the drug. After blockade of the α1-adrenoceptors by doxazosin in the controls, phenylephrine mimicked the reaction in Raynaud subjects. β-Adrenoceptor agonists (isoprenaline and terbutaline) had no effect on finger blood flow in the examined finger skin area in either control or Raynaud subjects. We suggest that Raynaud’s disease is characterized by a defect in α1-adrenoceptor function.</description><subject>Adult</subject><subject>Azepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Doxazosin</subject><subject>Female</subject><subject>Fingers - blood supply</subject><subject>Humans</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>phenylephrine</subject><subject>Prazosin - analogs & derivatives</subject><subject>Prazosin - pharmacology</subject><subject>Raynaud Disease - physiopathology</subject><subject>Raynaud's disease</subject><subject>Receptors, Adrenergic - drug effects</subject><subject>Receptors, Adrenergic - physiology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Skin - blood supply</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1KwzAUgIMoc04fQejF8K6aNCc_vRzzFwaC6HU4bVNW7dqZtIzd-Rq-nk9i6-ruxMAhhPOdk-Q7hASMXjIaqyvaLcEBQhbrmEXdKeyCwQEZM8F5CDTih2RMmaRhBCCPyYn3rz0hlByRUQSaKaXGZDrLnK3q1K6b2vmgqIIn3FbYZl8fnz64LrxFb0_JUY6lt2fDPiEvtzfP8_tw8Xj3MJ8twhSkgDCWCUeFwBAgyZBKxiKuJU1i0BJQ0zyBGDOMslygpTzRPJec08SmgkKu-YRc7PquXf3eWt-YVeFTW5ZY2br1RsXAlBDyX5AJkFpp2oF6B6au9t7Z3KxdsUK3NYya3qT5NWn2Js2Pya70fLijTVY22xcO6rr8dMijT7HMHVZp4feYVN0Tov5PsMM2ddlY59_KdmOdWVosm6X5a478G-HRiQ4</recordid><startdate>198912</startdate><enddate>198912</enddate><creator>Lindblad, Lars Erik</creator><creator>Ekenvall, Lena</creator><creator>Etzell, Britt-Marie</creator><creator>Bevegård, Sture</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198912</creationdate><title>Adrenoceptors in Raynaud’s Disease</title><author>Lindblad, Lars Erik ; Ekenvall, Lena ; Etzell, Britt-Marie ; Bevegård, Sture</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4654-96b3a7a41a44bda061123860b94864a80fb49ada2df5ae03b83f6330bec504f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Azepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Doxazosin</topic><topic>Female</topic><topic>Fingers - blood supply</topic><topic>Humans</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>phenylephrine</topic><topic>Prazosin - analogs & derivatives</topic><topic>Prazosin - pharmacology</topic><topic>Raynaud Disease - physiopathology</topic><topic>Raynaud's disease</topic><topic>Receptors, Adrenergic - drug effects</topic><topic>Receptors, Adrenergic - physiology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Skin - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindblad, Lars Erik</creatorcontrib><creatorcontrib>Ekenvall, Lena</creatorcontrib><creatorcontrib>Etzell, Britt-Marie</creatorcontrib><creatorcontrib>Bevegård, Sture</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindblad, Lars Erik</au><au>Ekenvall, Lena</au><au>Etzell, Britt-Marie</au><au>Bevegård, Sture</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenoceptors in Raynaud’s Disease</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1989-12</date><risdate>1989</risdate><volume>14</volume><issue>6</issue><spage>881</spage><epage>885</epage><pages>881-885</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>Experiments were designed to study adrenoceptor function in subjects with Raynaud’s disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepinephrine (NE, stimulating α1-and α2-adrenoceptors), phenylephrine (stimulating α1-adrenoceptors), and B-HT 933 (stimulating α2-adrenoceptors) were studied in 12 women with Raynaud’s disease and in 12 healthy controls. Controls and cases showed a similar consistent vasoconstriction to NE and B-HT 933. All control subjects showed a vasoconstriction to phenylephrine. In contrast, the Raynaud subjects demonstrated a weaker vasoconstriction or even a vasodilation, especially to low concentrations of the drug. After blockade of the α1-adrenoceptors by doxazosin in the controls, phenylephrine mimicked the reaction in Raynaud subjects. β-Adrenoceptor agonists (isoprenaline and terbutaline) had no effect on finger blood flow in the examined finger skin area in either control or Raynaud subjects. We suggest that Raynaud’s disease is characterized by a defect in α1-adrenoceptor function.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2481777</pmid><doi>10.1097/00005344-198912000-00014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Azepines - pharmacology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Doxazosin Female Fingers - blood supply Humans Isoproterenol - pharmacology Male Medical sciences Middle Aged norepinephrine Norepinephrine - pharmacology phenylephrine Prazosin - analogs & derivatives Prazosin - pharmacology Raynaud Disease - physiopathology Raynaud's disease Receptors, Adrenergic - drug effects Receptors, Adrenergic - physiology Regional Blood Flow - drug effects Skin - blood supply |
| title | Adrenoceptors in Raynaud’s Disease |
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