Ontogeny of elongation and gene expression in the early developing porcine conceptus
Early porcine conceptus development is characterized by rapid trophoblastic elongation between Days 11 and 12 of pregnancy, a period of embryonic loss in the pig. Growth factors and steroids secreted by the conceptus and uterus, as well as ligand receptors produced by the conceptus, are thought to r...
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| Veröffentlicht in: | Biology of reproduction 1997-11, Vol.57 (5), p.1256-1265 |
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| creator | Yelich, J.V. (Oklahoma State University, Stillwater, OK.) Pomp, D Geisert, R.D |
| description | Early porcine conceptus development is characterized by rapid trophoblastic elongation between Days 11 and 12 of pregnancy,
a period of embryonic loss in the pig. Growth factors and steroids secreted by the conceptus and uterus, as well as ligand
receptors produced by the conceptus, are thought to regulate trophoblastic elongation. Therefore, the objectives of this study
were to characterize conceptus gene expression for the steroidogenic enzymes 17alpha-hydroxylase and aromatase and the mesodermal
marker brachyury, as well as the expression of receptors for fibronectin (integrin beta-1), progesterone, estrogen, oxytocin,
prostaglandin F2alpha, and leukemia inhibitory factor (LIF), prior to and during trophoblastic elongation. Total RNA was extracted
from individual conceptuses from Day 10 to Day 12 of pregnancy. Gene expression was determined by reverse transcription polymerase
chain reaction on conceptuses having 2- to 4-, 5-, 6-, 7-, 8-, 9-, and 10- to 12-mm spherical, 13- to 25-mm tubular, and >
100-mm filamentous morphologies. There was a stage of development effect on both 17alpha-hydroxylase (p < 0.001) and aromatase
(p < 0.003) gene expression. Initial 17alpha-hydroxylase gene expression was detected in early spherical conceptuses (2-4
mm), increasing abruptly through to 7-mm conceptuses. Aromatase gene expression increased dramatically in 6- to 7-mm conceptuses,
with increased expression throughout development. Gene expression for LIF receptor (LIFR) (p < 0.02) was similar to that for
17alpha-hydroxylase, while brachyury gene expression began in 6-mm conceptuses and increased (p < 0.001) throughout development.
Integrin beta-1 was expressed at all stages of development. Conceptus gene expression was not detected for progesterone, estrogen,
oxytocin, and prostaglandin F2alpha receptors. Prior to elongation, dynamic changes in gene expression are occurring that
appear to be associated with estrogen production and preparation of the conceptuses for elongation. LIFR expression is highly
associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation, suggesting
that LIF may be involved in early conceptus development in the pig. |
| doi_str_mv | 10.1095/biolreprod57.5.1256 |
| format | Article |
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a period of embryonic loss in the pig. Growth factors and steroids secreted by the conceptus and uterus, as well as ligand
receptors produced by the conceptus, are thought to regulate trophoblastic elongation. Therefore, the objectives of this study
were to characterize conceptus gene expression for the steroidogenic enzymes 17alpha-hydroxylase and aromatase and the mesodermal
marker brachyury, as well as the expression of receptors for fibronectin (integrin beta-1), progesterone, estrogen, oxytocin,
prostaglandin F2alpha, and leukemia inhibitory factor (LIF), prior to and during trophoblastic elongation. Total RNA was extracted
from individual conceptuses from Day 10 to Day 12 of pregnancy. Gene expression was determined by reverse transcription polymerase
chain reaction on conceptuses having 2- to 4-, 5-, 6-, 7-, 8-, 9-, and 10- to 12-mm spherical, 13- to 25-mm tubular, and >
100-mm filamentous morphologies. There was a stage of development effect on both 17alpha-hydroxylase (p < 0.001) and aromatase
(p < 0.003) gene expression. Initial 17alpha-hydroxylase gene expression was detected in early spherical conceptuses (2-4
mm), increasing abruptly through to 7-mm conceptuses. Aromatase gene expression increased dramatically in 6- to 7-mm conceptuses,
with increased expression throughout development. Gene expression for LIF receptor (LIFR) (p < 0.02) was similar to that for
17alpha-hydroxylase, while brachyury gene expression began in 6-mm conceptuses and increased (p < 0.001) throughout development.
Integrin beta-1 was expressed at all stages of development. Conceptus gene expression was not detected for progesterone, estrogen,
oxytocin, and prostaglandin F2alpha receptors. Prior to elongation, dynamic changes in gene expression are occurring that
appear to be associated with estrogen production and preparation of the conceptuses for elongation. LIFR expression is highly
associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation, suggesting
that LIF may be involved in early conceptus development in the pig.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod57.5.1256</identifier><identifier>PMID: 9369195</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>17ALPHA-HYDROXYLASE ; Animals ; AROMATASE ; Aromatase - metabolism ; Biological and medical sciences ; BRACHYURY ; CYTOKINES ; Densitometry ; DNA - analysis ; DNA - isolation & purification ; DURATION ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryo, Mammalian - enzymology ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - genetics ; Embryonic and Fetal Development - physiology ; EMBRYONIC DEVELOPMENT ; Female ; FIBRONECTINS ; Fundamental and applied biological sciences. Psychology ; GENE EXPRESSION ; Gene Expression Regulation, Developmental - physiology ; GENES ; GENETIC MARKERS ; GLYCOPROTEINS ; Growth Inhibitors ; HORMONE RECEPTORS ; INTEGIN BETA-1 ; Integrin beta1 - biosynthesis ; Integrin beta1 - genetics ; Interleukin-6 ; LEUKEMIA INHIBITORY FACTOR ; Lymphokines ; MARKER GENES ; MESSENGER RNA ; MORPHOLOGY ; OXIDOREDUCTASES ; OXYGENASES ; Polymerase Chain Reaction ; PREGNANCY ; PREIMPLANTATION PERIOD ; RECEPTORS ; Receptors, Cell Surface - biosynthesis ; Receptors, Cytokine - biosynthesis ; Receptors, Cytokine - genetics ; Receptors, OSM-LIF ; RNA, Messenger - analysis ; RNA, Messenger - biosynthesis ; RNA, Messenger - isolation & purification ; Steroid 17-alpha-Hydroxylase - metabolism ; STRUCTURAL GENES ; SWINE ; TROPHOBLAST ; TROPHOBLASTIC ELONGATION</subject><ispartof>Biology of reproduction, 1997-11, Vol.57 (5), p.1256-1265</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2048530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9369195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yelich, J.V. (Oklahoma State University, Stillwater, OK.)</creatorcontrib><creatorcontrib>Pomp, D</creatorcontrib><creatorcontrib>Geisert, R.D</creatorcontrib><title>Ontogeny of elongation and gene expression in the early developing porcine conceptus</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Early porcine conceptus development is characterized by rapid trophoblastic elongation between Days 11 and 12 of pregnancy,
a period of embryonic loss in the pig. Growth factors and steroids secreted by the conceptus and uterus, as well as ligand
receptors produced by the conceptus, are thought to regulate trophoblastic elongation. Therefore, the objectives of this study
were to characterize conceptus gene expression for the steroidogenic enzymes 17alpha-hydroxylase and aromatase and the mesodermal
marker brachyury, as well as the expression of receptors for fibronectin (integrin beta-1), progesterone, estrogen, oxytocin,
prostaglandin F2alpha, and leukemia inhibitory factor (LIF), prior to and during trophoblastic elongation. Total RNA was extracted
from individual conceptuses from Day 10 to Day 12 of pregnancy. Gene expression was determined by reverse transcription polymerase
chain reaction on conceptuses having 2- to 4-, 5-, 6-, 7-, 8-, 9-, and 10- to 12-mm spherical, 13- to 25-mm tubular, and >
100-mm filamentous morphologies. There was a stage of development effect on both 17alpha-hydroxylase (p < 0.001) and aromatase
(p < 0.003) gene expression. Initial 17alpha-hydroxylase gene expression was detected in early spherical conceptuses (2-4
mm), increasing abruptly through to 7-mm conceptuses. Aromatase gene expression increased dramatically in 6- to 7-mm conceptuses,
with increased expression throughout development. Gene expression for LIF receptor (LIFR) (p < 0.02) was similar to that for
17alpha-hydroxylase, while brachyury gene expression began in 6-mm conceptuses and increased (p < 0.001) throughout development.
Integrin beta-1 was expressed at all stages of development. Conceptus gene expression was not detected for progesterone, estrogen,
oxytocin, and prostaglandin F2alpha receptors. Prior to elongation, dynamic changes in gene expression are occurring that
appear to be associated with estrogen production and preparation of the conceptuses for elongation. LIFR expression is highly
associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation, suggesting
that LIF may be involved in early conceptus development in the pig.</description><subject>17ALPHA-HYDROXYLASE</subject><subject>Animals</subject><subject>AROMATASE</subject><subject>Aromatase - metabolism</subject><subject>Biological and medical sciences</subject><subject>BRACHYURY</subject><subject>CYTOKINES</subject><subject>Densitometry</subject><subject>DNA - analysis</subject><subject>DNA - isolation & purification</subject><subject>DURATION</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>Embryo, Mammalian - enzymology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development - genetics</subject><subject>Embryonic and Fetal Development - physiology</subject><subject>EMBRYONIC DEVELOPMENT</subject><subject>Female</subject><subject>FIBRONECTINS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE EXPRESSION</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>GENES</subject><subject>GENETIC MARKERS</subject><subject>GLYCOPROTEINS</subject><subject>Growth Inhibitors</subject><subject>HORMONE RECEPTORS</subject><subject>INTEGIN BETA-1</subject><subject>Integrin beta1 - biosynthesis</subject><subject>Integrin beta1 - genetics</subject><subject>Interleukin-6</subject><subject>LEUKEMIA INHIBITORY FACTOR</subject><subject>Lymphokines</subject><subject>MARKER GENES</subject><subject>MESSENGER RNA</subject><subject>MORPHOLOGY</subject><subject>OXIDOREDUCTASES</subject><subject>OXYGENASES</subject><subject>Polymerase Chain Reaction</subject><subject>PREGNANCY</subject><subject>PREIMPLANTATION PERIOD</subject><subject>RECEPTORS</subject><subject>Receptors, Cell Surface - biosynthesis</subject><subject>Receptors, Cytokine - biosynthesis</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, OSM-LIF</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - isolation & purification</subject><subject>Steroid 17-alpha-Hydroxylase - metabolism</subject><subject>STRUCTURAL GENES</subject><subject>SWINE</subject><subject>TROPHOBLAST</subject><subject>TROPHOBLASTIC ELONGATION</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY8_oLxChFuKu2rwfSxlGRxiYhTPrkMqjOpJOyqTatv-9GWzUnasL53ycezkXgDcIbhFU7MMUS6p-qcUxsWVbhBl_BjaIYTUKzOVzsIEQ8pEQTl6Cy9a-QYgoweQCXCjCFVJsAx7u81pmn09DCYNPJc9mjSUPJruhy37wP5fqW3vSYh7WXVdMTafB-R8dX2Keh6VUGztqS7Z-WQ_tFXgRTGr-9XlegcdPNw_Xt-Pd_ecv1x_vxkCQWkcenPcTdshg6Zjj1sGJkMCZCpOUUkjhnFEoWGpY4MQ4RSiV04RtJxmF5Aq8_53bO_h-8G3V-9isT8lkXw5NC0URU1T8F0ScQIkV6uDbM3iY9t7ppca9qSd97qv7786-adakUE22sf3BMKSSkX8O28V5d4zV67Y3KfVQoo_HIxOa6ad3_d0XTNFmrj3r8StSSkDJKBLkFx3Ik2U</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Yelich, J.V. (Oklahoma State University, Stillwater, OK.)</creator><creator>Pomp, D</creator><creator>Geisert, R.D</creator><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Ontogeny of elongation and gene expression in the early developing porcine conceptus</title><author>Yelich, J.V. (Oklahoma State University, Stillwater, OK.) ; Pomp, D ; Geisert, R.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f319t-6fdeeb2d1a28d5d6cd0b33f659fb888787dda91fc4a5f63ad93448bb2ccd05403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>17ALPHA-HYDROXYLASE</topic><topic>Animals</topic><topic>AROMATASE</topic><topic>Aromatase - metabolism</topic><topic>Biological and medical sciences</topic><topic>BRACHYURY</topic><topic>CYTOKINES</topic><topic>Densitometry</topic><topic>DNA - analysis</topic><topic>DNA - isolation & purification</topic><topic>DURATION</topic><topic>Early stages. Segmentation. Gastrulation. Neurulation</topic><topic>Embryo, Mammalian - enzymology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development - genetics</topic><topic>Embryonic and Fetal Development - physiology</topic><topic>EMBRYONIC DEVELOPMENT</topic><topic>Female</topic><topic>FIBRONECTINS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE EXPRESSION</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>GENES</topic><topic>GENETIC MARKERS</topic><topic>GLYCOPROTEINS</topic><topic>Growth Inhibitors</topic><topic>HORMONE RECEPTORS</topic><topic>INTEGIN BETA-1</topic><topic>Integrin beta1 - biosynthesis</topic><topic>Integrin beta1 - genetics</topic><topic>Interleukin-6</topic><topic>LEUKEMIA INHIBITORY FACTOR</topic><topic>Lymphokines</topic><topic>MARKER GENES</topic><topic>MESSENGER RNA</topic><topic>MORPHOLOGY</topic><topic>OXIDOREDUCTASES</topic><topic>OXYGENASES</topic><topic>Polymerase Chain Reaction</topic><topic>PREGNANCY</topic><topic>PREIMPLANTATION PERIOD</topic><topic>RECEPTORS</topic><topic>Receptors, Cell Surface - biosynthesis</topic><topic>Receptors, Cytokine - biosynthesis</topic><topic>Receptors, Cytokine - genetics</topic><topic>Receptors, OSM-LIF</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - isolation & purification</topic><topic>Steroid 17-alpha-Hydroxylase - metabolism</topic><topic>STRUCTURAL GENES</topic><topic>SWINE</topic><topic>TROPHOBLAST</topic><topic>TROPHOBLASTIC ELONGATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yelich, J.V. (Oklahoma State University, Stillwater, OK.)</creatorcontrib><creatorcontrib>Pomp, D</creatorcontrib><creatorcontrib>Geisert, R.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yelich, J.V. (Oklahoma State University, Stillwater, OK.)</au><au>Pomp, D</au><au>Geisert, R.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogeny of elongation and gene expression in the early developing porcine conceptus</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>57</volume><issue>5</issue><spage>1256</spage><epage>1265</epage><pages>1256-1265</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Early porcine conceptus development is characterized by rapid trophoblastic elongation between Days 11 and 12 of pregnancy,
a period of embryonic loss in the pig. Growth factors and steroids secreted by the conceptus and uterus, as well as ligand
receptors produced by the conceptus, are thought to regulate trophoblastic elongation. Therefore, the objectives of this study
were to characterize conceptus gene expression for the steroidogenic enzymes 17alpha-hydroxylase and aromatase and the mesodermal
marker brachyury, as well as the expression of receptors for fibronectin (integrin beta-1), progesterone, estrogen, oxytocin,
prostaglandin F2alpha, and leukemia inhibitory factor (LIF), prior to and during trophoblastic elongation. Total RNA was extracted
from individual conceptuses from Day 10 to Day 12 of pregnancy. Gene expression was determined by reverse transcription polymerase
chain reaction on conceptuses having 2- to 4-, 5-, 6-, 7-, 8-, 9-, and 10- to 12-mm spherical, 13- to 25-mm tubular, and >
100-mm filamentous morphologies. There was a stage of development effect on both 17alpha-hydroxylase (p < 0.001) and aromatase
(p < 0.003) gene expression. Initial 17alpha-hydroxylase gene expression was detected in early spherical conceptuses (2-4
mm), increasing abruptly through to 7-mm conceptuses. Aromatase gene expression increased dramatically in 6- to 7-mm conceptuses,
with increased expression throughout development. Gene expression for LIF receptor (LIFR) (p < 0.02) was similar to that for
17alpha-hydroxylase, while brachyury gene expression began in 6-mm conceptuses and increased (p < 0.001) throughout development.
Integrin beta-1 was expressed at all stages of development. Conceptus gene expression was not detected for progesterone, estrogen,
oxytocin, and prostaglandin F2alpha receptors. Prior to elongation, dynamic changes in gene expression are occurring that
appear to be associated with estrogen production and preparation of the conceptuses for elongation. LIFR expression is highly
associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation, suggesting
that LIF may be involved in early conceptus development in the pig.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>9369195</pmid><doi>10.1095/biolreprod57.5.1256</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 1997-11, Vol.57 (5), p.1256-1265 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79415947 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | 17ALPHA-HYDROXYLASE Animals AROMATASE Aromatase - metabolism Biological and medical sciences BRACHYURY CYTOKINES Densitometry DNA - analysis DNA - isolation & purification DURATION Early stages. Segmentation. Gastrulation. Neurulation Embryo, Mammalian - enzymology Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - genetics Embryonic and Fetal Development - physiology EMBRYONIC DEVELOPMENT Female FIBRONECTINS Fundamental and applied biological sciences. Psychology GENE EXPRESSION Gene Expression Regulation, Developmental - physiology GENES GENETIC MARKERS GLYCOPROTEINS Growth Inhibitors HORMONE RECEPTORS INTEGIN BETA-1 Integrin beta1 - biosynthesis Integrin beta1 - genetics Interleukin-6 LEUKEMIA INHIBITORY FACTOR Lymphokines MARKER GENES MESSENGER RNA MORPHOLOGY OXIDOREDUCTASES OXYGENASES Polymerase Chain Reaction PREGNANCY PREIMPLANTATION PERIOD RECEPTORS Receptors, Cell Surface - biosynthesis Receptors, Cytokine - biosynthesis Receptors, Cytokine - genetics Receptors, OSM-LIF RNA, Messenger - analysis RNA, Messenger - biosynthesis RNA, Messenger - isolation & purification Steroid 17-alpha-Hydroxylase - metabolism STRUCTURAL GENES SWINE TROPHOBLAST TROPHOBLASTIC ELONGATION |
| title | Ontogeny of elongation and gene expression in the early developing porcine conceptus |
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