Haemonchus contortus:Cloning and Functional Expression of a cDNA Encoding Ornithine Decarboxylase and Development of a Screen for Inhibitors

Polyamines (PA) are essential for viability and replication of all cells; organisms either synthesize PA or acquire them from the environment. How nematodes that parasitize the gut satisfy their PA requirement has not been resolved. The primary regulatory enzyme in PA biosynthesis in most animals is...

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Veröffentlicht in:	Experimental parasitology 1997-11, Vol.87 (3), p.171-184
Hauptverfasser:	Klein, R.D., Favreau, M.A., Alexander-Bowman, S.J., Nulf, S.C., Vanover, L., Winterrowd, C.A., Yarlett, N., Martinez, M., Keithly, J.S., Zantello, M.R., Thomas, E.M., Geary, T.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence cloning Cloning, Molecular DNA, Complementary - genetics Drug Evaluation, Preclinical - methods Enzyme Inhibitors Escherichia coli - genetics expression Genetic Complementation Test Haemonchus - enzymology Haemonchus - genetics Haemonchus contortus Helminth Proteins - drug effects Molecular Sequence Data nematode ornithine decarboxylase Ornithine Decarboxylase - genetics Ornithine Decarboxylase Inhibitors Polyamines Polyamines - metabolism Recombinant Proteins - biosynthesis Saccharomyces cerevisiae - genetics screen Selection, Genetic Sequence Homology, Amino Acid Stilbamidines - pharmacology yeast
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