PHARMACOKINETIC AND CLINICAL STUDIES ON CEFODIZIME IN GYNECOLOGIC FIELD
Pharmacokinetic and clinical studies on a new cephalosporin antibiotic, cefodizime (THR-221, CDZM), were performed and the results obtained are summarized as follows: 1. At about 84 minutes after a bolus injection of 1g dose of CDZM, the drug was tranferred well into tissues of internal genital orga...
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| Veröffentlicht in: | Japanese journal of antibiotics 1989/10/25, Vol.42(10), pp.2098-2106 |
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| container_title | Japanese journal of antibiotics |
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| creator | HANADA, SEIJI KINBARA, TOSHIHIRO AOKI, KOUJI YASUI, YOSHIE IKUTA, KATSUO MANZAI, MINORU MIZUNO, KINICHIROU YAGAMI, YOSHIAKI SAKAIDA, HIROSHI OKUMURA, YUTAKA IMANISHI, HARUHIKO KITAMURA, TAKASHI |
| description | Pharmacokinetic and clinical studies on a new cephalosporin antibiotic, cefodizime (THR-221, CDZM), were performed and the results obtained are summarized as follows: 1. At about 84 minutes after a bolus injection of 1g dose of CDZM, the drug was tranferred well into tissues of internal genital organs and remained there at therapeutic levels for 285 minutes. The drug was also transferred quickly and sufficiently into exudate from pelvic dead space and its levels were still kept at high levels at 6 hours after administration. 2. CDZM was given to 8 women affected with gynecologic infections. The outcome of CDZM therapies showed that the drug was effective in all 8 of patients (100%) clinically and bacteriologically. 3. Notable adverse effects or abnormal laboratory test results were not observed except for 2 patients with transient and slight elevation of transaminase levels. Based on these results, it may be concluded that CDZM is a highly effective and a very safe antibiotic for the treatment on infectious diseases in gynecologic field. |
| doi_str_mv | 10.11553/antibiotics1968b.42.2098 |
| format | Article |
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At about 84 minutes after a bolus injection of 1g dose of CDZM, the drug was tranferred well into tissues of internal genital organs and remained there at therapeutic levels for 285 minutes. The drug was also transferred quickly and sufficiently into exudate from pelvic dead space and its levels were still kept at high levels at 6 hours after administration. 2. CDZM was given to 8 women affected with gynecologic infections. The outcome of CDZM therapies showed that the drug was effective in all 8 of patients (100%) clinically and bacteriologically. 3. Notable adverse effects or abnormal laboratory test results were not observed except for 2 patients with transient and slight elevation of transaminase levels. Based on these results, it may be concluded that CDZM is a highly effective and a very safe antibiotic for the treatment on infectious diseases in gynecologic field.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.42.2098</identifier><identifier>PMID: 2607600</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Bacterial Infections - drug therapy ; Bacterial Infections - metabolism ; Cefotaxime - administration & dosage ; Cefotaxime - analogs & derivatives ; Cefotaxime - pharmacokinetics ; Cefotaxime - pharmacology ; Drug Evaluation ; Female ; Genital Diseases, Female - drug therapy ; Genital Diseases, Female - metabolism ; Genitalia, Female - metabolism ; Humans ; Injections, Intravenous ; Middle Aged ; Pelvic Inflammatory Disease - drug therapy ; Pelvic Inflammatory Disease - metabolism ; Tissue Distribution</subject><ispartof>The Japanese Journal of Antibiotics, 1989/10/25, Vol.42(10), pp.2098-2106</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2607600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HANADA, SEIJI</creatorcontrib><creatorcontrib>KINBARA, TOSHIHIRO</creatorcontrib><creatorcontrib>AOKI, KOUJI</creatorcontrib><creatorcontrib>YASUI, YOSHIE</creatorcontrib><creatorcontrib>IKUTA, KATSUO</creatorcontrib><creatorcontrib>MANZAI, MINORU</creatorcontrib><creatorcontrib>MIZUNO, KINICHIROU</creatorcontrib><creatorcontrib>YAGAMI, YOSHIAKI</creatorcontrib><creatorcontrib>SAKAIDA, HIROSHI</creatorcontrib><creatorcontrib>OKUMURA, YUTAKA</creatorcontrib><creatorcontrib>IMANISHI, HARUHIKO</creatorcontrib><creatorcontrib>KITAMURA, TAKASHI</creatorcontrib><title>PHARMACOKINETIC AND CLINICAL STUDIES ON CEFODIZIME IN GYNECOLOGIC FIELD</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>Pharmacokinetic and clinical studies on a new cephalosporin antibiotic, cefodizime (THR-221, CDZM), were performed and the results obtained are summarized as follows: 1. At about 84 minutes after a bolus injection of 1g dose of CDZM, the drug was tranferred well into tissues of internal genital organs and remained there at therapeutic levels for 285 minutes. The drug was also transferred quickly and sufficiently into exudate from pelvic dead space and its levels were still kept at high levels at 6 hours after administration. 2. CDZM was given to 8 women affected with gynecologic infections. The outcome of CDZM therapies showed that the drug was effective in all 8 of patients (100%) clinically and bacteriologically. 3. Notable adverse effects or abnormal laboratory test results were not observed except for 2 patients with transient and slight elevation of transaminase levels. Based on these results, it may be concluded that CDZM is a highly effective and a very safe antibiotic for the treatment on infectious diseases in gynecologic field.</description><subject>Adult</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - metabolism</subject><subject>Cefotaxime - administration & dosage</subject><subject>Cefotaxime - analogs & derivatives</subject><subject>Cefotaxime - pharmacokinetics</subject><subject>Cefotaxime - pharmacology</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Genital Diseases, Female - drug therapy</subject><subject>Genital Diseases, Female - metabolism</subject><subject>Genitalia, Female - metabolism</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Middle Aged</subject><subject>Pelvic Inflammatory Disease - drug therapy</subject><subject>Pelvic Inflammatory Disease - metabolism</subject><subject>Tissue Distribution</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1OwkAURidGgwR5BJO6cVec_5kum7bAxNIagYVuJtN2qiUFtC0L394ihIWbexffuV9yDwAPCE4QYow8mV1XZdW-q_IWeVxmE4onGHryCgwxktxlVIhrMISESxcLiW7BuG2rDBIkJO4rBmCAORQcwiGYvcz914UfpM8qiVYqcPwkdIJYJSrwY2e5WocqWjpp4gTRNA3Vu1pEjkqc2VsSBWmczvqLqYri8A7clKZu7fi8R2A9jVbB3P1j_NjdIA92LkWUEEpkQSExnmC4MCWiBmYQCc4zC2le5txmwtrSMlnkxjDEc2YZg5BbSkbg8dT71ey_D7bt9LZqc1vXZmf3h1YLjyIiJenB-zN4yLa20F9NtTXNjz5_3ufxKd-0nfmwl9w0vdfa6v-SNcUaweM8qr5g-adptN2RX4suc64</recordid><startdate>198910</startdate><enddate>198910</enddate><creator>HANADA, SEIJI</creator><creator>KINBARA, TOSHIHIRO</creator><creator>AOKI, KOUJI</creator><creator>YASUI, YOSHIE</creator><creator>IKUTA, KATSUO</creator><creator>MANZAI, MINORU</creator><creator>MIZUNO, KINICHIROU</creator><creator>YAGAMI, YOSHIAKI</creator><creator>SAKAIDA, HIROSHI</creator><creator>OKUMURA, YUTAKA</creator><creator>IMANISHI, HARUHIKO</creator><creator>KITAMURA, TAKASHI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198910</creationdate><title>PHARMACOKINETIC AND CLINICAL STUDIES ON CEFODIZIME IN GYNECOLOGIC FIELD</title><author>HANADA, SEIJI ; KINBARA, TOSHIHIRO ; AOKI, KOUJI ; YASUI, YOSHIE ; IKUTA, KATSUO ; MANZAI, MINORU ; MIZUNO, KINICHIROU ; YAGAMI, YOSHIAKI ; SAKAIDA, HIROSHI ; OKUMURA, YUTAKA ; IMANISHI, HARUHIKO ; KITAMURA, TAKASHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j190t-41433438d403a9752daf14a0b01766be04cfc6eb7eefe58dcaa516c5e55006e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - metabolism</topic><topic>Cefotaxime - administration & dosage</topic><topic>Cefotaxime - analogs & derivatives</topic><topic>Cefotaxime - pharmacokinetics</topic><topic>Cefotaxime - pharmacology</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Genital Diseases, Female - drug therapy</topic><topic>Genital Diseases, Female - metabolism</topic><topic>Genitalia, Female - metabolism</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Middle Aged</topic><topic>Pelvic Inflammatory Disease - drug therapy</topic><topic>Pelvic Inflammatory Disease - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HANADA, SEIJI</creatorcontrib><creatorcontrib>KINBARA, TOSHIHIRO</creatorcontrib><creatorcontrib>AOKI, KOUJI</creatorcontrib><creatorcontrib>YASUI, YOSHIE</creatorcontrib><creatorcontrib>IKUTA, KATSUO</creatorcontrib><creatorcontrib>MANZAI, MINORU</creatorcontrib><creatorcontrib>MIZUNO, KINICHIROU</creatorcontrib><creatorcontrib>YAGAMI, YOSHIAKI</creatorcontrib><creatorcontrib>SAKAIDA, HIROSHI</creatorcontrib><creatorcontrib>OKUMURA, YUTAKA</creatorcontrib><creatorcontrib>IMANISHI, HARUHIKO</creatorcontrib><creatorcontrib>KITAMURA, TAKASHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HANADA, SEIJI</au><au>KINBARA, TOSHIHIRO</au><au>AOKI, KOUJI</au><au>YASUI, YOSHIE</au><au>IKUTA, KATSUO</au><au>MANZAI, MINORU</au><au>MIZUNO, KINICHIROU</au><au>YAGAMI, YOSHIAKI</au><au>SAKAIDA, HIROSHI</au><au>OKUMURA, YUTAKA</au><au>IMANISHI, HARUHIKO</au><au>KITAMURA, TAKASHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PHARMACOKINETIC AND CLINICAL STUDIES ON CEFODIZIME IN GYNECOLOGIC FIELD</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1989-10</date><risdate>1989</risdate><volume>42</volume><issue>10</issue><spage>2098</spage><epage>2106</epage><pages>2098-2106</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>Pharmacokinetic and clinical studies on a new cephalosporin antibiotic, cefodizime (THR-221, CDZM), were performed and the results obtained are summarized as follows: 1. At about 84 minutes after a bolus injection of 1g dose of CDZM, the drug was tranferred well into tissues of internal genital organs and remained there at therapeutic levels for 285 minutes. The drug was also transferred quickly and sufficiently into exudate from pelvic dead space and its levels were still kept at high levels at 6 hours after administration. 2. CDZM was given to 8 women affected with gynecologic infections. The outcome of CDZM therapies showed that the drug was effective in all 8 of patients (100%) clinically and bacteriologically. 3. 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| ispartof | The Japanese Journal of Antibiotics, 1989/10/25, Vol.42(10), pp.2098-2106 |
| issn | 0368-2781 2186-5477 |
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| subjects | Adult Bacterial Infections - drug therapy Bacterial Infections - metabolism Cefotaxime - administration & dosage Cefotaxime - analogs & derivatives Cefotaxime - pharmacokinetics Cefotaxime - pharmacology Drug Evaluation Female Genital Diseases, Female - drug therapy Genital Diseases, Female - metabolism Genitalia, Female - metabolism Humans Injections, Intravenous Middle Aged Pelvic Inflammatory Disease - drug therapy Pelvic Inflammatory Disease - metabolism Tissue Distribution |
| title | PHARMACOKINETIC AND CLINICAL STUDIES ON CEFODIZIME IN GYNECOLOGIC FIELD |
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