Studies on Orally Active Cephalosporin Esters. II. : Chemical Stability of Pivaloyloxymethyl Esters in Phosphate Buffer Solution

The degradation kinetics of pivaloyloxymethyl (POM) esters of cephalosporins in phosphate buffer solution (pH6-8) were investigated. The degradation of the starting Δ3 cephalosporin ester proceeded mainly via isomerization to the Δ2 ester and subsequent hydrolysis to the Δ2 acid. Hydrolysis to the Δ...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/09/25, Vol.37(9), pp.2369-2374
Hauptverfasser:	MIYAUCHI, Masao, SASAHARA, Kunihiro, FUJIMOTO, Koichi, KAWAMOTO, Isao, IDE, Junya, NAKAO, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Buffers cefpodoxime proxetil cephalosporin Cephalosporins - administration & dosage Cephalosporins - chemical synthesis Cephalosporins - pharmacokinetics Chemical Phenomena Chemistry CS-807 Drug Stability Esters Exact sciences and technology isomerization kinetics Kinetics and mechanisms Organic chemistry Pentanoic Acids - administration & dosage Pentanoic Acids - chemical synthesis Pentanoic Acids - pharmacokinetics Phosphates prodrug Reactivity and mechanisms stability Δ2 cephalosporin
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