Lipoprotein lipase, LDL receptors and apo-lipoproteins in human fetal membranes at term
Ultrastructurally, all cells of human fetal membranes strongly exhibit a large amount of lipid deposits throughout pregnancy. Their origin and function is still unknown. The aim of this study was to investigate the localization of key components of lipid metabolism in this tissue. Using immunohistoc...
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| Veröffentlicht in: | Placenta (Eastbourne) 1997-11, Vol.18 (8), p.707-715 |
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| creator | Huter, O. Wolf, H.J. Schnetzer, A. Pfaller, K. |
| description | Ultrastructurally, all cells of human fetal membranes strongly exhibit a large amount of lipid deposits throughout pregnancy. Their origin and function is still unknown. The aim of this study was to investigate the localization of key components of lipid metabolism in this tissue. Using immunohistochemical techniques, the distribution of lipoprotein lipase (LPL), low density lipoprotein receptors (LDL receptors), and apo-lipoprotein B and E was investigated in 20 human fetal membranes at term. In addition, electron microscopy was used to study the intracellular localization of lipoprotein-sized particles. Amnionic epithelium and trophoblast cells reacted strongly for LPL. LDL receptors and apo-lipoproteins were present in Ammonic epithelium and fibroblasts of the amnion. In none of the investigated cells were lipoprotein-sized particles identified. Similar results were obtained in all 20 cases. The findings indicate that lipoprotein from the amniotic fluid or from the maternal circulation may serve as substrate for lipids in human fetal membranes. |
| doi_str_mv | 10.1016/S0143-4004(97)90013-8 |
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Their origin and function is still unknown. The aim of this study was to investigate the localization of key components of lipid metabolism in this tissue. Using immunohistochemical techniques, the distribution of lipoprotein lipase (LPL), low density lipoprotein receptors (LDL receptors), and apo-lipoprotein B and E was investigated in 20 human fetal membranes at term. In addition, electron microscopy was used to study the intracellular localization of lipoprotein-sized particles. Amnionic epithelium and trophoblast cells reacted strongly for LPL. LDL receptors and apo-lipoproteins were present in Ammonic epithelium and fibroblasts of the amnion. In none of the investigated cells were lipoprotein-sized particles identified. Similar results were obtained in all 20 cases. The findings indicate that lipoprotein from the amniotic fluid or from the maternal circulation may serve as substrate for lipids in human fetal membranes.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/S0143-4004(97)90013-8</identifier><identifier>PMID: 9364607</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amnion - chemistry ; Amnion - cytology ; Amnion - enzymology ; Apolipoproteins - analysis ; Biological and medical sciences ; Chorion - chemistry ; Chorion - cytology ; Chorion - enzymology ; Embryology: invertebrates and vertebrates. Teratology ; Epithelial Cells - chemistry ; Epithelial Cells - enzymology ; Epithelial Cells - ultrastructure ; Female ; Fetal membranes ; Fibroblasts - chemistry ; Fibroblasts - cytology ; Fibroblasts - enzymology ; Fundamental and applied biological sciences. Psychology ; General aspects. 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Fetal membranes ; Humans ; Immunohistochemistry ; Lipoprotein Lipase - analysis ; Microscopy, Electron ; Pregnancy ; Receptors, LDL - analysis ; Trophoblasts - chemistry ; Trophoblasts - cytology ; Trophoblasts - enzymology</subject><ispartof>Placenta (Eastbourne), 1997-11, Vol.18 (8), p.707-715</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-71313357c022f7ba4e96b37a147f50e231b17fef3405c4f7fc6b5e6905e49d9e3</citedby><cites>FETCH-LOGICAL-c389t-71313357c022f7ba4e96b37a147f50e231b17fef3405c4f7fc6b5e6905e49d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400497900138$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2845323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9364607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huter, O.</creatorcontrib><creatorcontrib>Wolf, H.J.</creatorcontrib><creatorcontrib>Schnetzer, A.</creatorcontrib><creatorcontrib>Pfaller, K.</creatorcontrib><title>Lipoprotein lipase, LDL receptors and apo-lipoproteins in human fetal membranes at term</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Ultrastructurally, all cells of human fetal membranes strongly exhibit a large amount of lipid deposits throughout pregnancy. Their origin and function is still unknown. The aim of this study was to investigate the localization of key components of lipid metabolism in this tissue. Using immunohistochemical techniques, the distribution of lipoprotein lipase (LPL), low density lipoprotein receptors (LDL receptors), and apo-lipoprotein B and E was investigated in 20 human fetal membranes at term. In addition, electron microscopy was used to study the intracellular localization of lipoprotein-sized particles. Amnionic epithelium and trophoblast cells reacted strongly for LPL. LDL receptors and apo-lipoproteins were present in Ammonic epithelium and fibroblasts of the amnion. In none of the investigated cells were lipoprotein-sized particles identified. Similar results were obtained in all 20 cases. The findings indicate that lipoprotein from the amniotic fluid or from the maternal circulation may serve as substrate for lipids in human fetal membranes.</description><subject>Amnion - chemistry</subject><subject>Amnion - cytology</subject><subject>Amnion - enzymology</subject><subject>Apolipoproteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Chorion - chemistry</subject><subject>Chorion - cytology</subject><subject>Chorion - enzymology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Epithelial Cells - chemistry</subject><subject>Epithelial Cells - enzymology</subject><subject>Epithelial Cells - ultrastructure</subject><subject>Female</subject><subject>Fetal membranes</subject><subject>Fibroblasts - chemistry</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - enzymology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Development. Fetal membranes</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lipoprotein Lipase - analysis</subject><subject>Microscopy, Electron</subject><subject>Pregnancy</subject><subject>Receptors, LDL - analysis</subject><subject>Trophoblasts - chemistry</subject><subject>Trophoblasts - cytology</subject><subject>Trophoblasts - enzymology</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LJDEQhsOiuKPuTxjIQURhWyuddGdyEhl3VWjwoOIxpNMVNtJfJj2C_96MM4zHPdWhnqp684SQOYMLBqy8fAQmeCYAxJmS5wqA8Wzxg8xYwfOMM8j3yGyH_CSHMb4CgBIsPyAHipeiBDkjL5UfhzEME_qetn40EX_T6qaiAS2O0xAiNX1DzThk7TcZaaL_rTrTU4eTaWmHXR1Mj4me6IShOyb7zrQRf23rEXn---dpeZdVD7f3y-sqs3yhpkwyzjgvpIU8d7I2AlVZc2mYkK4AzDmrmXTouIDCCiedLesCSwUFCtUo5EfkdLM3JXtbYZx056PFtk1hhlXUMj2YlcATWGxAG4YYAzo9Bt-Z8KEZ6LVQ_SVUr21pJfWXUL1Ic_PtgVXdYbOb2hpM_ZNt30RrWpcsWB93WL4Q6T_W5682GCYZ7x6DjtZjb7HxyfSkm8H_J8gniNeRZA</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Huter, O.</creator><creator>Wolf, H.J.</creator><creator>Schnetzer, A.</creator><creator>Pfaller, K.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Lipoprotein lipase, LDL receptors and apo-lipoproteins in human fetal membranes at term</title><author>Huter, O. ; Wolf, H.J. ; Schnetzer, A. ; Pfaller, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-71313357c022f7ba4e96b37a147f50e231b17fef3405c4f7fc6b5e6905e49d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amnion - chemistry</topic><topic>Amnion - cytology</topic><topic>Amnion - enzymology</topic><topic>Apolipoproteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Chorion - chemistry</topic><topic>Chorion - cytology</topic><topic>Chorion - enzymology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Epithelial Cells - chemistry</topic><topic>Epithelial Cells - enzymology</topic><topic>Epithelial Cells - ultrastructure</topic><topic>Female</topic><topic>Fetal membranes</topic><topic>Fibroblasts - chemistry</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - enzymology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Development. Fetal membranes</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lipoprotein Lipase - analysis</topic><topic>Microscopy, Electron</topic><topic>Pregnancy</topic><topic>Receptors, LDL - analysis</topic><topic>Trophoblasts - chemistry</topic><topic>Trophoblasts - cytology</topic><topic>Trophoblasts - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huter, O.</creatorcontrib><creatorcontrib>Wolf, H.J.</creatorcontrib><creatorcontrib>Schnetzer, A.</creatorcontrib><creatorcontrib>Pfaller, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huter, O.</au><au>Wolf, H.J.</au><au>Schnetzer, A.</au><au>Pfaller, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein lipase, LDL receptors and apo-lipoproteins in human fetal membranes at term</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>18</volume><issue>8</issue><spage>707</spage><epage>715</epage><pages>707-715</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Ultrastructurally, all cells of human fetal membranes strongly exhibit a large amount of lipid deposits throughout pregnancy. Their origin and function is still unknown. The aim of this study was to investigate the localization of key components of lipid metabolism in this tissue. Using immunohistochemical techniques, the distribution of lipoprotein lipase (LPL), low density lipoprotein receptors (LDL receptors), and apo-lipoprotein B and E was investigated in 20 human fetal membranes at term. In addition, electron microscopy was used to study the intracellular localization of lipoprotein-sized particles. Amnionic epithelium and trophoblast cells reacted strongly for LPL. LDL receptors and apo-lipoproteins were present in Ammonic epithelium and fibroblasts of the amnion. In none of the investigated cells were lipoprotein-sized particles identified. Similar results were obtained in all 20 cases. The findings indicate that lipoprotein from the amniotic fluid or from the maternal circulation may serve as substrate for lipids in human fetal membranes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9364607</pmid><doi>10.1016/S0143-4004(97)90013-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Amnion - chemistry Amnion - cytology Amnion - enzymology Apolipoproteins - analysis Biological and medical sciences Chorion - chemistry Chorion - cytology Chorion - enzymology Embryology: invertebrates and vertebrates. Teratology Epithelial Cells - chemistry Epithelial Cells - enzymology Epithelial Cells - ultrastructure Female Fetal membranes Fibroblasts - chemistry Fibroblasts - cytology Fibroblasts - enzymology Fundamental and applied biological sciences. Psychology General aspects. Development. Fetal membranes Humans Immunohistochemistry Lipoprotein Lipase - analysis Microscopy, Electron Pregnancy Receptors, LDL - analysis Trophoblasts - chemistry Trophoblasts - cytology Trophoblasts - enzymology |
| title | Lipoprotein lipase, LDL receptors and apo-lipoproteins in human fetal membranes at term |
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