Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration
Apc-associated intestinal tumor formation appears to require functional loss of both Apc alleles. Apc has, therefore, been classified as a tumor suppressor gene. Loss of APC protein function results in increased intracellular beta-catenin, a molecule important to both cell-cell adhesion and regulati...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1997-11, Vol.57 (22), p.5045-5050 |
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