Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

Expression of the apoptosis-inhibitory protein Bcl-2 has frequently been detected in human cancer including mammary carcinoma. The functional significance of its expression has been well established in experimental tumors of the lymphoid system, however, remains to be elucidated for epithelial tumor...

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Veröffentlicht in:	Oncogene 1997-10, Vol.15 (15), p.1787-1795
Hauptverfasser:	JÄGER, R, HERZER, U, SCHENKEL, J, WEIHER, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Apoptosis Apoptosis - genetics Bcl-2 protein Biological and medical sciences c-Myc protein Carcinoma Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Epithelial cells Epithelium Fundamental and applied biological sciences. Psychology Genes, myc Humans Mammary gland Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic Molecular and cellular biology Myc protein Proto-Oncogene Proteins c-bcl-2 - genetics Rodents Transgenic animals Transgenic mice Tumorigenesis Tumors
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