Convertase PC2 and the neuroendocrine polypeptide 7B2 are co-induced and processed during neuronal differentiation of P19 embryonal carcinoma cells

Convertases of the subtilisin/kexin family are responsible for the biological activation of a variety of pro-proteins, pro-hormones, and pro-trophic factors, and thus can modulate various aspects of embryonic development. We investigated the expression of each convertase by Northern hybridization du...

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Veröffentlicht in:	DNA and cell biology 1997-10, Vol.16 (10), p.1175-1187
Hauptverfasser:	Jeannotte, R, Paquin, J, Petit-Turcotte, C, Day, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Embryonal - enzymology Carcinoma, Embryonal - genetics Carcinoma, Embryonal - metabolism Cell Differentiation - drug effects Enzyme Induction Furin Gene Expression Regulation, Developmental - physiology Lewis X Antigen - analysis Mesoderm Mice Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroendocrine Secretory Protein 7B2 Neurofilament Proteins - analysis Neurons - cytology Neurons - enzymology Pituitary Hormones - biosynthesis Pituitary Hormones - genetics Pituitary Hormones - metabolism Proprotein Convertase 2 Proprotein Convertase 5 Proprotein Convertases Protein Processing, Post-Translational RNA, Messenger - analysis Serine Endopeptidases - genetics Subtilisins - biosynthesis Subtilisins - genetics Subtilisins - metabolism Tretinoin - pharmacology Tumor Cells, Cultured
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