Embryonic retinal grafts have a beneficial effect on the damaged host retina
The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted i...
Gespeichert in:
Veröffentlicht in: | Brain research 1989-10, Vol.500 (1), p.61-66 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of this degenerative response. In addition, the embryonic graft also exerted a stimulatory effect in the central direction from the lesion site, as increases in layer thicknesses were seen. We speculate that putative diffusable factor(s) may mediate these effects. |
---|---|
ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/0006-8993(89)90300-4 |