Embryonic retinal grafts have a beneficial effect on the damaged host retina

The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted i...

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Veröffentlicht in:Brain research 1989-10, Vol.500 (1), p.61-66
Hauptverfasser: Laedtke, Thomas W., Turner, James E.
Format: Artikel
Sprache:eng
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Zusammenfassung:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of this degenerative response. In addition, the embryonic graft also exerted a stimulatory effect in the central direction from the lesion site, as increases in layer thicknesses were seen. We speculate that putative diffusable factor(s) may mediate these effects.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(89)90300-4