Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro
Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the m...
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| Veröffentlicht in: | Hormone and metabolic research 1997-09, Vol.29 (9), p.427-429 |
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| container_title | Hormone and metabolic research |
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| creator | Mitsuma, T. Rhue, N. Kayama, M. Yokoi, Y. Izumi, M. Adachi, K. Wago, T. Hirooka, Y. Nogimori, T. |
| description | Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro. |
| doi_str_mv | 10.1055/s-2007-979070 |
| format | Article |
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The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-979070</identifier><identifier>PMID: 9370109</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Bacitracin - pharmacology ; Bicuculline - pharmacology ; Dose-Response Relationship, Drug ; GABA Antagonists - pharmacology ; gamma-Aminobutyric Acid - administration & dosage ; gamma-Aminobutyric Acid - pharmacology ; Hydrogen-Ion Concentration ; Male ; Originals Basic ; Rats ; Rats, Wistar ; Retina - drug effects ; Retina - secretion ; Thyrotropin-Releasing Hormone - secretion</subject><ispartof>Hormone and metabolic research, 1997-09, Vol.29 (9), p.427-429</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-979070.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9370109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitsuma, T.</creatorcontrib><creatorcontrib>Rhue, N.</creatorcontrib><creatorcontrib>Kayama, M.</creatorcontrib><creatorcontrib>Yokoi, Y.</creatorcontrib><creatorcontrib>Izumi, M.</creatorcontrib><creatorcontrib>Adachi, K.</creatorcontrib><creatorcontrib>Wago, T.</creatorcontrib><creatorcontrib>Hirooka, Y.</creatorcontrib><creatorcontrib>Nogimori, T.</creatorcontrib><title>Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro.</description><subject>Animals</subject><subject>Bacitracin - pharmacology</subject><subject>Bicuculline - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>GABA Antagonists - pharmacology</subject><subject>gamma-Aminobutyric Acid - administration & dosage</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Originals Basic</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Retina - drug effects</subject><subject>Retina - secretion</subject><subject>Thyrotropin-Releasing Hormone - secretion</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1rGzEQxUVJSd20xxwDOuVUtaMPr6RjGlKnECiU9Cy02tlaxrtyJW3A_33WXdNbT8PM-70H8wi55vCZw3r9pTABoJnVFjS8ISuupGVKmOaCrAC4YWtQ8h15X8puXpXl6pJcWqmBg12R3UPfY6iFpp5u_DB49nWqxxwDvQuxo2mkdYv0J-7RFzxBz9tjTjWnQxxZ_nuO42_6mPKQRqR9TsPi8HV21Th6Gkf6EmfHB_K29_uCH8_zivz69vB8_8iefmy-3989sSAMr8yKTqMIIrTcWi1BQMvN2tgObQjSKi8BIaima0yre8llaHQfWtN65J1RKK_I7ZJ7yOnPhKW6IZaA-70fMU3FaaugEcLMIFvAkFMpGXt3yHHw-eg4uFO3rrhTt27pduZvzsFTO2D3jz6XOeufFr1uIw7odmnK4_zpf-JeAdKdglM</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Mitsuma, T.</creator><creator>Rhue, N.</creator><creator>Kayama, M.</creator><creator>Yokoi, Y.</creator><creator>Izumi, M.</creator><creator>Adachi, K.</creator><creator>Wago, T.</creator><creator>Hirooka, Y.</creator><creator>Nogimori, T.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro</title><author>Mitsuma, T. ; Rhue, N. ; Kayama, M. ; Yokoi, Y. ; Izumi, M. ; Adachi, K. ; Wago, T. ; Hirooka, Y. ; Nogimori, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-92d7e2c2cb19973020b18589de9cc394a30e0c46d68b7f313c67fcb8bae1d84e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Bacitracin - pharmacology</topic><topic>Bicuculline - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>GABA Antagonists - pharmacology</topic><topic>gamma-Aminobutyric Acid - administration & dosage</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Originals Basic</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Retina - drug effects</topic><topic>Retina - secretion</topic><topic>Thyrotropin-Releasing Hormone - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitsuma, T.</creatorcontrib><creatorcontrib>Rhue, N.</creatorcontrib><creatorcontrib>Kayama, M.</creatorcontrib><creatorcontrib>Yokoi, Y.</creatorcontrib><creatorcontrib>Izumi, M.</creatorcontrib><creatorcontrib>Adachi, K.</creatorcontrib><creatorcontrib>Wago, T.</creatorcontrib><creatorcontrib>Hirooka, Y.</creatorcontrib><creatorcontrib>Nogimori, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitsuma, T.</au><au>Rhue, N.</au><au>Kayama, M.</au><au>Yokoi, Y.</au><au>Izumi, M.</au><au>Adachi, K.</au><au>Wago, T.</au><au>Hirooka, Y.</au><au>Nogimori, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>29</volume><issue>9</issue><spage>427</spage><epage>429</epage><pages>427-429</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro.</abstract><cop>Germany</cop><pmid>9370109</pmid><doi>10.1055/s-2007-979070</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Bacitracin - pharmacology Bicuculline - pharmacology Dose-Response Relationship, Drug GABA Antagonists - pharmacology gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - pharmacology Hydrogen-Ion Concentration Male Originals Basic Rats Rats, Wistar Retina - drug effects Retina - secretion Thyrotropin-Releasing Hormone - secretion |
| title | Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro |
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