Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-α

Purified myelin from mouse brain was found to contain two forms of neutral sphingomyelinase, one Mg2+ dependent and the other Mg2+ independent. The former had a pH optimum of 7.5 and Km of 0.35 mM, whereas the corresponding values for the latter were pH 8.0 and Km 3.03 mM. Specific activity of the M...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroscience research 1997-11, Vol.50 (3), p.466-476
Hauptverfasser:	Chakraborty, G., Ziemba, S., Drivas, A., Ledeen, R.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Animals Brain - enzymology Brain Stem - enzymology Cell Fractionation ceramide Ceramides - metabolism cholesterol ester Cholesterol Esters - metabolism Choline - metabolism demyelination mechanism Diglycerides - metabolism Isoenzymes - metabolism Kinetics Magnesium - pharmacology Mice myelin Myelin Sheath - drug effects Myelin Sheath - enzymology Myelin Sheath - metabolism myelin-localized enzymes Phosphatidylcholines - metabolism signal transduction in myelin sphingomyelin Sphingomyelin Phosphodiesterase - metabolism sphingomyelinase tumor necrosis factor tumor necrosis factor receptor Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!