Effect of Fasciola hepatica excretory-secretory products on the metabolic burst of sheep and human neutrophils
F. hepatica excretory-secretory (ES) products were found to inhibit superoxide output in phorbol myristate acetate (PMA)-stimulated sheep and human neutrophils as measured by spectrophotometry. Luminol-enhanced chemiluminescence by PMA-stimulated neutrophils from both species was again inhibited. Ho...
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| Veröffentlicht in: | International journal for parasitology 1997-09, Vol.27 (9), p.1025-1029 |
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| container_title | International journal for parasitology |
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| creator | Jefferies, J.R. Turner, R.J. Barrett, J. |
| description | F. hepatica excretory-secretory (ES) products were found to inhibit superoxide output in phorbol myristate acetate (PMA)-stimulated sheep and human neutrophils as measured by spectrophotometry. Luminol-enhanced chemiluminescence by PMA-stimulated neutrophils from both species was again inhibited. However, nitric oxide output by PMA-stimulated human neutrophils was significantly increased in the presence of ES products, whilst in sheep it was inhibited. No major effects were noted using resting neutrophils. The results are discussed in relation to the evolution of parasite defence mechanisms. |
| doi_str_mv | 10.1016/S0020-7519(97)00067-2 |
| format | Article |
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Luminol-enhanced chemiluminescence by PMA-stimulated neutrophils from both species was again inhibited. However, nitric oxide output by PMA-stimulated human neutrophils was significantly increased in the presence of ES products, whilst in sheep it was inhibited. No major effects were noted using resting neutrophils. The results are discussed in relation to the evolution of parasite defence mechanisms.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/S0020-7519(97)00067-2</identifier><identifier>PMID: 9363484</identifier><identifier>CODEN: IJPYBT</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; chemiluminescence ; Experimental helminthic diseases. 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Luminol-enhanced chemiluminescence by PMA-stimulated neutrophils from both species was again inhibited. However, nitric oxide output by PMA-stimulated human neutrophils was significantly increased in the presence of ES products, whilst in sheep it was inhibited. No major effects were noted using resting neutrophils. The results are discussed in relation to the evolution of parasite defence mechanisms.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>chemiluminescence</subject><subject>Experimental helminthic diseases. 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Models</topic><topic>Fasciola hepatica - immunology</topic><topic>Fasciola hepatica excretory-secretory products</topic><topic>Female</topic><topic>Helminthic diseases</topic><topic>human neutrophils</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolic burst</topic><topic>Neutrophils - metabolism</topic><topic>Parasitic diseases</topic><topic>Respiratory Burst</topic><topic>Sheep</topic><topic>Sheep neutrophils</topic><topic>Species Specificity</topic><topic>Superoxides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jefferies, J.R.</creatorcontrib><creatorcontrib>Turner, R.J.</creatorcontrib><creatorcontrib>Barrett, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jefferies, J.R.</au><au>Turner, R.J.</au><au>Barrett, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Fasciola hepatica excretory-secretory products on the metabolic burst of sheep and human neutrophils</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>27</volume><issue>9</issue><spage>1025</spage><epage>1029</epage><pages>1025-1029</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><coden>IJPYBT</coden><abstract>F. hepatica excretory-secretory (ES) products were found to inhibit superoxide output in phorbol myristate acetate (PMA)-stimulated sheep and human neutrophils as measured by spectrophotometry. 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| fulltext | fulltext |
| identifier | ISSN: 0020-7519 |
| ispartof | International journal for parasitology, 1997-09, Vol.27 (9), p.1025-1029 |
| issn | 0020-7519 1879-0135 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences chemiluminescence Experimental helminthic diseases. Models Fasciola hepatica - immunology Fasciola hepatica excretory-secretory products Female Helminthic diseases human neutrophils Humans Infectious diseases Male Medical sciences metabolic burst Neutrophils - metabolism Parasitic diseases Respiratory Burst Sheep Sheep neutrophils Species Specificity Superoxides - metabolism |
| title | Effect of Fasciola hepatica excretory-secretory products on the metabolic burst of sheep and human neutrophils |
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