Human recombinant interferon‐β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors
Type I interferons (IFN) are important regulators of both innate and acquired immunity. We have used an in vitro system of human CD4+ T cell differentiation to determine how IFN‐β influences development of T helper (Th) subsets and homing receptor expression. IFN‐β promoted differentiation of CD4+ T...
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| Veröffentlicht in: | European journal of immunology 1997-10, Vol.27 (10), p.2650-2656 |
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| creator | McRae, Bradford L. Picker, Louis J. van Seventer, Gijs A. |
| description | Type I interferons (IFN) are important regulators of both innate and acquired immunity. We have used an in vitro system of human CD4+ T cell differentiation to determine how IFN‐β influences development of T helper (Th) subsets and homing receptor expression. IFN‐β promoted differentiation of CD4+ T cells that produce low levels of both IFN‐γ and lymphotoxin compared to interleukin (IL)‐12‐derived Th1 CD4+ T cells. IFN‐β inhibited production of Th2 cytokines (IL‐5 and IL‐13) and augmented IL‐12‐mediated IL‐10 secretion. In addition, IFN‐β significantly enhanced L‐selectin expression on CD4+ T cells and synergized with IL‐12 to induce expression of cutaneous lymphocyte‐associated antigen (CLA). This Th1 L‐selectin+, CLA+ phenotype is characteristic of T cells found in normal human skin and suggests a role for type I IFN in the regulation of Th subset differentiation and tissue‐specific homing receptors. |
| doi_str_mv | 10.1002/eji.1830271026 |
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We have used an in vitro system of human CD4+ T cell differentiation to determine how IFN‐β influences development of T helper (Th) subsets and homing receptor expression. IFN‐β promoted differentiation of CD4+ T cells that produce low levels of both IFN‐γ and lymphotoxin compared to interleukin (IL)‐12‐derived Th1 CD4+ T cells. IFN‐β inhibited production of Th2 cytokines (IL‐5 and IL‐13) and augmented IL‐12‐mediated IL‐10 secretion. In addition, IFN‐β significantly enhanced L‐selectin expression on CD4+ T cells and synergized with IL‐12 to induce expression of cutaneous lymphocyte‐associated antigen (CLA). This Th1 L‐selectin+, CLA+ phenotype is characteristic of T cells found in normal human skin and suggests a role for type I IFN in the regulation of Th subset differentiation and tissue‐specific homing receptors.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830271026</identifier><identifier>PMID: 9368622</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>AIDS/HIV ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Neoplasm ; Cell Differentiation - drug effects ; Cells, Cultured ; Cytokine ; Gene Expression Regulation - drug effects ; Homing ; Human ; Humans ; Interferon-beta - pharmacology ; Interferon‐β ; Interleukin-10 - biosynthesis ; Interleukin-10 - genetics ; Interleukin-10 - secretion ; Interleukin-12 - pharmacology ; Interleukin-13 - biosynthesis ; Interleukin-13 - genetics ; Interleukin-13 - secretion ; Interleukin-5 - biosynthesis ; Interleukin-5 - genetics ; Interleukin-5 - secretion ; L-Selectin - biosynthesis ; L-Selectin - genetics ; Lymphokines - biosynthesis ; Lymphokines - genetics ; Lymphokines - secretion ; Lymphotoxin-alpha - biosynthesis ; Lymphotoxin-alpha - genetics ; Lymphotoxin-alpha - secretion ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - genetics ; Organ Specificity ; Phenotype ; Receptors, Lymphocyte Homing - biosynthesis ; Receptors, Lymphocyte Homing - genetics ; Recombinant Fusion Proteins - pharmacology ; T lymphocyte ; Th1 Cells - drug effects ; Th1 Cells - metabolism ; Th1 Cells - secretion ; Th2 Cells - drug effects ; Th2 Cells - metabolism ; Th2 Cells - secretion</subject><ispartof>European journal of immunology, 1997-10, Vol.27 (10), p.2650-2656</ispartof><rights>Copyright © 1997 WILEY‐VCH Verlag GmbH & Co. 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We have used an in vitro system of human CD4+ T cell differentiation to determine how IFN‐β influences development of T helper (Th) subsets and homing receptor expression. IFN‐β promoted differentiation of CD4+ T cells that produce low levels of both IFN‐γ and lymphotoxin compared to interleukin (IL)‐12‐derived Th1 CD4+ T cells. IFN‐β inhibited production of Th2 cytokines (IL‐5 and IL‐13) and augmented IL‐12‐mediated IL‐10 secretion. In addition, IFN‐β significantly enhanced L‐selectin expression on CD4+ T cells and synergized with IL‐12 to induce expression of cutaneous lymphocyte‐associated antigen (CLA). This Th1 L‐selectin+, CLA+ phenotype is characteristic of T cells found in normal human skin and suggests a role for type I IFN in the regulation of Th subset differentiation and tissue‐specific homing receptors.</description><subject>AIDS/HIV</subject><subject>Antigens, Differentiation, T-Lymphocyte</subject><subject>Antigens, Neoplasm</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>Cytokine</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Homing</subject><subject>Human</subject><subject>Humans</subject><subject>Interferon-beta - pharmacology</subject><subject>Interferon‐β</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - secretion</subject><subject>Interleukin-12 - pharmacology</subject><subject>Interleukin-13 - biosynthesis</subject><subject>Interleukin-13 - genetics</subject><subject>Interleukin-13 - secretion</subject><subject>Interleukin-5 - biosynthesis</subject><subject>Interleukin-5 - genetics</subject><subject>Interleukin-5 - secretion</subject><subject>L-Selectin - biosynthesis</subject><subject>L-Selectin - genetics</subject><subject>Lymphokines - biosynthesis</subject><subject>Lymphokines - genetics</subject><subject>Lymphokines - secretion</subject><subject>Lymphotoxin-alpha - biosynthesis</subject><subject>Lymphotoxin-alpha - genetics</subject><subject>Lymphotoxin-alpha - secretion</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Organ Specificity</subject><subject>Phenotype</subject><subject>Receptors, Lymphocyte Homing - biosynthesis</subject><subject>Receptors, Lymphocyte Homing - genetics</subject><subject>Recombinant Fusion Proteins - pharmacology</subject><subject>T lymphocyte</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - metabolism</subject><subject>Th1 Cells - secretion</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - metabolism</subject><subject>Th2 Cells - secretion</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAQxy1URJePK7dKPvWWrb_iOMcKUaBC4gLnyHEmYJrYqe2o3RuPwJHn6IP0IXiSersr4MZpNDO_-dnSH6FjSpaUEPYF7u2SKk5YRQmTO2hBS0YLQQX9gBaEUFGwWpGPaD_Ge0JILct6D-3VXCrJ2AI9nc-jdjiA8WNrnXYJW5cg9BC8e354_Psn9_0wgzMQ8TW-g2GCgOPcRki4s30GwSWrk_UOt6tsup2H3LlbbFbJ_7AOcAQT4D8w6ZTlDmvXYfg9BYhxPfY9vvPj-iZ_BKbkQzxEu70eIhxt6wG6-XZ6fXJeXF6dXZx8vSwMr6gsNOs6Ba3goiOipkxVSvESOO1Z1dUVlEryyvCSKVVWSiojgLVEZZy2phOaH6DPG-8U_M8ZYmpGGw0Mg3bg59hUtSBUCfkuSCUT-QmSweUGNMHHGKBvpmBHHVYNJc06syZn1rxmlg8-bc1zO0L3gm9Dyvt6s_9lB1i9Y2tOv1-8cf8Dmken1A</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>McRae, Bradford L.</creator><creator>Picker, Louis J.</creator><creator>van Seventer, Gijs A.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199710</creationdate><title>Human recombinant interferon‐β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors</title><author>McRae, Bradford L. ; Picker, Louis J. ; van Seventer, Gijs A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3716-a2dd8eb434d04912878835e31f27d97e58637c3528857868c4e2b0834d1bcd4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS/HIV</topic><topic>Antigens, Differentiation, T-Lymphocyte</topic><topic>Antigens, Neoplasm</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>Cytokine</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Homing</topic><topic>Human</topic><topic>Humans</topic><topic>Interferon-beta - pharmacology</topic><topic>Interferon‐β</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - secretion</topic><topic>Interleukin-12 - pharmacology</topic><topic>Interleukin-13 - biosynthesis</topic><topic>Interleukin-13 - genetics</topic><topic>Interleukin-13 - secretion</topic><topic>Interleukin-5 - biosynthesis</topic><topic>Interleukin-5 - genetics</topic><topic>Interleukin-5 - secretion</topic><topic>L-Selectin - biosynthesis</topic><topic>L-Selectin - genetics</topic><topic>Lymphokines - biosynthesis</topic><topic>Lymphokines - genetics</topic><topic>Lymphokines - secretion</topic><topic>Lymphotoxin-alpha - biosynthesis</topic><topic>Lymphotoxin-alpha - genetics</topic><topic>Lymphotoxin-alpha - secretion</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Organ Specificity</topic><topic>Phenotype</topic><topic>Receptors, Lymphocyte Homing - biosynthesis</topic><topic>Receptors, Lymphocyte Homing - genetics</topic><topic>Recombinant Fusion Proteins - pharmacology</topic><topic>T lymphocyte</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - metabolism</topic><topic>Th1 Cells - secretion</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - metabolism</topic><topic>Th2 Cells - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McRae, Bradford L.</creatorcontrib><creatorcontrib>Picker, Louis J.</creatorcontrib><creatorcontrib>van Seventer, Gijs A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McRae, Bradford L.</au><au>Picker, Louis J.</au><au>van Seventer, Gijs A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human recombinant interferon‐β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1997-10</date><risdate>1997</risdate><volume>27</volume><issue>10</issue><spage>2650</spage><epage>2656</epage><pages>2650-2656</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Type I interferons (IFN) are important regulators of both innate and acquired immunity. We have used an in vitro system of human CD4+ T cell differentiation to determine how IFN‐β influences development of T helper (Th) subsets and homing receptor expression. IFN‐β promoted differentiation of CD4+ T cells that produce low levels of both IFN‐γ and lymphotoxin compared to interleukin (IL)‐12‐derived Th1 CD4+ T cells. IFN‐β inhibited production of Th2 cytokines (IL‐5 and IL‐13) and augmented IL‐12‐mediated IL‐10 secretion. In addition, IFN‐β significantly enhanced L‐selectin expression on CD4+ T cells and synergized with IL‐12 to induce expression of cutaneous lymphocyte‐associated antigen (CLA). This Th1 L‐selectin+, CLA+ phenotype is characteristic of T cells found in normal human skin and suggests a role for type I IFN in the regulation of Th subset differentiation and tissue‐specific homing receptors.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>9368622</pmid><doi>10.1002/eji.1830271026</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of immunology, 1997-10, Vol.27 (10), p.2650-2656 |
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| subjects | AIDS/HIV Antigens, Differentiation, T-Lymphocyte Antigens, Neoplasm Cell Differentiation - drug effects Cells, Cultured Cytokine Gene Expression Regulation - drug effects Homing Human Humans Interferon-beta - pharmacology Interferon‐β Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-10 - secretion Interleukin-12 - pharmacology Interleukin-13 - biosynthesis Interleukin-13 - genetics Interleukin-13 - secretion Interleukin-5 - biosynthesis Interleukin-5 - genetics Interleukin-5 - secretion L-Selectin - biosynthesis L-Selectin - genetics Lymphokines - biosynthesis Lymphokines - genetics Lymphokines - secretion Lymphotoxin-alpha - biosynthesis Lymphotoxin-alpha - genetics Lymphotoxin-alpha - secretion Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Organ Specificity Phenotype Receptors, Lymphocyte Homing - biosynthesis Receptors, Lymphocyte Homing - genetics Recombinant Fusion Proteins - pharmacology T lymphocyte Th1 Cells - drug effects Th1 Cells - metabolism Th1 Cells - secretion Th2 Cells - drug effects Th2 Cells - metabolism Th2 Cells - secretion |
| title | Human recombinant interferon‐β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors |
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