High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival
Background Carcinoembryonic antigen (CEA) inhibits lymphocyte function and patients with cancer have lower cell‐mediated immunity (CMI) than the normal population. To test this association an investigation was made of the relationship between CMI score, CEA level and survival. Methods CEA level, CMI...
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| Veröffentlicht in: | British journal of surgery 1997-10, Vol.84 (10), p.1382-1385 |
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| creator | King, J. Caplehorn, J. R. M. Ross, W. B. Morris, D. L. |
| description | Background Carcinoembryonic antigen (CEA) inhibits lymphocyte function and patients with cancer have lower cell‐mediated immunity (CMI) than the normal population. To test this association an investigation was made of the relationship between CMI score, CEA level and survival.
Methods CEA level, CMI score and other variables were compared with the survival time of 109 patients with colorectal liver metastases using Cox regression analysis.
Results There was a significant association between CMI and CEA categories (P = 0·04, χ2 test). The odds of patients with normal CMI having a CEA level in the upper quartile observed for all patients were 22 per cent of those of patients with depressed CMI (odds ratio 0·22 (95 per cent confidence interval (c.i.) 0·03–0·90), (mid3 corrected). The median survival time of patients with normal CMI scores was 943 days compared with 488 days for those with depressed CMI (P = 0·03, log rank test; P = 0·04, Peto). The mortality risk of patients with normal CMI at entry to the study was, in the first 2 years of treatment, 40 per cent of that of patients with depressed CMI (95 per cent c.i. for relative risk 0·20–0·82, Cox regression).
Conclusion In patients with colorectal hepatic metastases, CMI is predictive of survival and a raised serum CEA level is associated with depressed CMI. |
| doi_str_mv | 10.1111/j.1365-2168.1997.02838.x |
| format | Article |
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Methods CEA level, CMI score and other variables were compared with the survival time of 109 patients with colorectal liver metastases using Cox regression analysis.
Results There was a significant association between CMI and CEA categories (P = 0·04, χ2 test). The odds of patients with normal CMI having a CEA level in the upper quartile observed for all patients were 22 per cent of those of patients with depressed CMI (odds ratio 0·22 (95 per cent confidence interval (c.i.) 0·03–0·90), (mid3 corrected). The median survival time of patients with normal CMI scores was 943 days compared with 488 days for those with depressed CMI (P = 0·03, log rank test; P = 0·04, Peto). The mortality risk of patients with normal CMI at entry to the study was, in the first 2 years of treatment, 40 per cent of that of patients with depressed CMI (95 per cent c.i. for relative risk 0·20–0·82, Cox regression).
Conclusion In patients with colorectal hepatic metastases, CMI is predictive of survival and a raised serum CEA level is associated with depressed CMI.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1111/j.1365-2168.1997.02838.x</identifier><identifier>PMID: 9361594</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoembryonic Antigen - blood ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - immunology ; Colorectal Neoplasms - mortality ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunity, Cellular ; Liver Neoplasms - blood ; Liver Neoplasms - immunology ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Male ; Medical sciences ; Middle Aged ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Survival Rate ; Tumors</subject><ispartof>British journal of surgery, 1997-10, Vol.84 (10), p.1382-1385</ispartof><rights>Copyright © 1997 British Journal of Surgery Society Ltd.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2168.1997.02838.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2168.1997.02838.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2834105$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9361594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, J.</creatorcontrib><creatorcontrib>Caplehorn, J. R. M.</creatorcontrib><creatorcontrib>Ross, W. B.</creatorcontrib><creatorcontrib>Morris, D. L.</creatorcontrib><title>High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background Carcinoembryonic antigen (CEA) inhibits lymphocyte function and patients with cancer have lower cell‐mediated immunity (CMI) than the normal population. To test this association an investigation was made of the relationship between CMI score, CEA level and survival.
Methods CEA level, CMI score and other variables were compared with the survival time of 109 patients with colorectal liver metastases using Cox regression analysis.
Results There was a significant association between CMI and CEA categories (P = 0·04, χ2 test). The odds of patients with normal CMI having a CEA level in the upper quartile observed for all patients were 22 per cent of those of patients with depressed CMI (odds ratio 0·22 (95 per cent confidence interval (c.i.) 0·03–0·90), (mid3 corrected). The median survival time of patients with normal CMI scores was 943 days compared with 488 days for those with depressed CMI (P = 0·03, log rank test; P = 0·04, Peto). The mortality risk of patients with normal CMI at entry to the study was, in the first 2 years of treatment, 40 per cent of that of patients with depressed CMI (95 per cent c.i. for relative risk 0·20–0·82, Cox regression).
Conclusion In patients with colorectal hepatic metastases, CMI is predictive of survival and a raised serum CEA level is associated with depressed CMI.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - immunology</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UduO0zAUjBBoKQufgOQHxBMJvsRJ_AgFdkEVCAEC7YvlOu72lMQOttPLT_GNOKSqZcnWmfHIM5NliOCCpPV6VxBW8ZySqimIEHWBacOa4vggW1yAh9kCY1znhFH2OHsSwg5jwjCnV9mVYBXholxkf2_hfouC8WOPtPIarDP92p-cBY2UjXBvLNLOamOjVxGcRWDRkG5pENAB4jbBnfNGR9WhDvbGo95EFdI2AUFAKgSnQUXTzvTBOY-06bq8N-08h74fLcTTK3TYgt5OrwafQB2THnIbFEa_h73qnmaPNqoL5tn5vM5-fHj_fXmbr77cfFy-WeVAK87y1pSbNWPKlJRjXrUK44bXglOiRamVaqoUUqsrQWtiONVC15uWEkxIQzmpanadvZx1B-_-jCZE2UOY_qyscWOQtShxilgk4vMzcVwnO3Lw0Ct_kueAE_7ijKugVbfxymoIF1pqrSSYJ9pyph2gM6cLTLCc6pY7ObUqp1blVLf8X7c8yrefvpEmmUsihCWVfFaBEM3xoqL8b5k81Vz-_Hwjxbtfd_iOrORX9g8ygrJu</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>King, J.</creator><creator>Caplehorn, J. R. M.</creator><creator>Ross, W. B.</creator><creator>Morris, D. L.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199710</creationdate><title>High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival</title><author>King, J. ; Caplehorn, J. R. M. ; Ross, W. B. ; Morris, D. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2653-de4fb33ae425056da008579521c94caa86365dc69271e52c9c7fd210118251673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - immunology</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - immunology</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, J.</creatorcontrib><creatorcontrib>Caplehorn, J. R. M.</creatorcontrib><creatorcontrib>Ross, W. B.</creatorcontrib><creatorcontrib>Morris, D. L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, J.</au><au>Caplehorn, J. R. M.</au><au>Ross, W. B.</au><au>Morris, D. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1997-10</date><risdate>1997</risdate><volume>84</volume><issue>10</issue><spage>1382</spage><epage>1385</epage><pages>1382-1385</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background Carcinoembryonic antigen (CEA) inhibits lymphocyte function and patients with cancer have lower cell‐mediated immunity (CMI) than the normal population. To test this association an investigation was made of the relationship between CMI score, CEA level and survival.
Methods CEA level, CMI score and other variables were compared with the survival time of 109 patients with colorectal liver metastases using Cox regression analysis.
Results There was a significant association between CMI and CEA categories (P = 0·04, χ2 test). The odds of patients with normal CMI having a CEA level in the upper quartile observed for all patients were 22 per cent of those of patients with depressed CMI (odds ratio 0·22 (95 per cent confidence interval (c.i.) 0·03–0·90), (mid3 corrected). The median survival time of patients with normal CMI scores was 943 days compared with 488 days for those with depressed CMI (P = 0·03, log rank test; P = 0·04, Peto). The mortality risk of patients with normal CMI at entry to the study was, in the first 2 years of treatment, 40 per cent of that of patients with depressed CMI (95 per cent c.i. for relative risk 0·20–0·82, Cox regression).
Conclusion In patients with colorectal hepatic metastases, CMI is predictive of survival and a raised serum CEA level is associated with depressed CMI.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9361594</pmid><doi>10.1111/j.1365-2168.1997.02838.x</doi><tpages>4</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoembryonic Antigen - blood Colorectal Neoplasms - blood Colorectal Neoplasms - immunology Colorectal Neoplasms - mortality Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunity, Cellular Liver Neoplasms - blood Liver Neoplasms - immunology Liver Neoplasms - mortality Liver Neoplasms - secondary Male Medical sciences Middle Aged Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Survival Rate Tumors |
| title | High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival |
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