Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with...

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Veröffentlicht in:	Biological psychiatry (1969) 1997-11, Vol.42 (10), p.871-875
Hauptverfasser:	Kato, Tadafumi, Stine, O. Colin, McMahon, Francis J., Crowe, Raymond R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Affective disorder Biological and medical sciences Bipolar Disorder - genetics Bipolar Disorder - physiopathology Bipolar Disorder - psychology Bipolar disorders Brain - physiopathology Culture Techniques depression DNA, Mitochondrial - genetics energy metabolism Energy Metabolism - physiology Gene Deletion Humans Medical sciences Middle Aged molecular genetics Mood disorders mutation Point Mutation - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry suicide Suicide - psychology Templates, Genetic
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