Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder
Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with...
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| Veröffentlicht in: | Biological psychiatry (1969) 1997-11, Vol.42 (10), p.871-875 |
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| container_end_page | 875 |
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| container_issue | 10 |
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| container_title | Biological psychiatry (1969) |
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| creator | Kato, Tadafumi Stine, O. Colin McMahon, Francis J. Crowe, Raymond R. |
| description | Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. The ratio of deleted to wild-type mtDNA in cerebral cortex was significantly higher in patients with bipolar disorder [0.23 ± 0.18 (mean ± SD)%] compared with that in age-matched controls (0.06 ± 0.07%,
p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder. |
| doi_str_mv | 10.1016/S0006-3223(97)00012-7 |
| format | Article |
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p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affective disorder</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar disorders</subject><subject>Brain - physiopathology</subject><subject>Culture Techniques</subject><subject>depression</subject><subject>DNA, Mitochondrial - genetics</subject><subject>energy metabolism</subject><subject>Energy Metabolism - physiology</subject><subject>Gene Deletion</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>molecular genetics</subject><subject>Mood disorders</subject><subject>mutation</subject><subject>Point Mutation - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>suicide</subject><subject>Suicide - psychology</subject><subject>Templates, Genetic</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEQgC1ERVPKT0DyoUL0sMWP3fX6hFD6ihTBgXK2vPasYuSsg-0E8e9xyCrXnmZG881DH0KXlPyghLY3j4SQtuKM8WspvpeCskqcoBntBK9YTdgpmh2Rz-hLSs-lFIzRM3QmeSOloDOkFqOJoBNY7GEHPuEwYI3XLgezCqONTnv88_4OW_CQXRixG3FeAe6jLlmBNzo7GHPCry6vcO82weuIrUshWohf0adB-wQXUzxHT79__Zv_rZYPfxbzu2Vl6q7LVd1Bw6g1Qtf1IKBuoG9bvX9XCGEpG6g2pAHat0L2lNe6kRZq6LkwA--k4efo6rB3E8PLFlJWa5cMeK9HCNukhOSybVpawOYAmhhSijCoTXRrHd8UJWovVn2IVXtrSgr1IVaJMnc5Hdj2a7DHqclk6X-b-joZ7YeoR-PSEWNE0LZrCnZ7wIpq2DmIKpmiz4B1EUxWNrj_PPIO9fOUeQ</recordid><startdate>19971115</startdate><enddate>19971115</enddate><creator>Kato, Tadafumi</creator><creator>Stine, O. 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Colin ; McMahon, Francis J. ; Crowe, Raymond R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-48e521dc7a44f7e45eb66a0072777d12f1ac05e1b679b134a59de4eb37cf389c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affective disorder</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar disorders</topic><topic>Brain - physiopathology</topic><topic>Culture Techniques</topic><topic>depression</topic><topic>DNA, Mitochondrial - genetics</topic><topic>energy metabolism</topic><topic>Energy Metabolism - physiology</topic><topic>Gene Deletion</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>molecular genetics</topic><topic>Mood disorders</topic><topic>mutation</topic><topic>Point Mutation - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>suicide</topic><topic>Suicide - psychology</topic><topic>Templates, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kato, Tadafumi</creatorcontrib><creatorcontrib>Stine, O. Colin</creatorcontrib><creatorcontrib>McMahon, Francis J.</creatorcontrib><creatorcontrib>Crowe, Raymond R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, Tadafumi</au><au>Stine, O. Colin</au><au>McMahon, Francis J.</au><au>Crowe, Raymond R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1997-11-15</date><risdate>1997</risdate><volume>42</volume><issue>10</issue><spage>871</spage><epage>875</epage><pages>871-875</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. 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| subjects | Adult Adult and adolescent clinical studies Affective disorder Biological and medical sciences Bipolar Disorder - genetics Bipolar Disorder - physiopathology Bipolar Disorder - psychology Bipolar disorders Brain - physiopathology Culture Techniques depression DNA, Mitochondrial - genetics energy metabolism Energy Metabolism - physiology Gene Deletion Humans Medical sciences Middle Aged molecular genetics Mood disorders mutation Point Mutation - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry suicide Suicide - psychology Templates, Genetic |
| title | Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder |
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