Inhibition of animal models of autoimmune disease and the induction of non-specific suppressor cells by SK&F 105685 and related azaspiranes

SK&F 105685 ( N, N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride), administered orally to adjuvant arthritic (AA) rats inhibited immune-mediated hindpaw inflammation with an ED 50 of 20 mg/kg/day. Both prophylactic and therapeutic administration wer effective in this...

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Veröffentlicht in:	International journal of immunopharmacology 1989, Vol.11 (7), p.839-846
Hauptverfasser:	Badger, Alison M., DiMartino, Michael J., Talmadge, James E., Picker, Donald H., Schwartz, David A., Dorman, James W., Mirabelli, Christopher K., Hanna, Nabil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals Arthritis, Experimental - immunology Autoimmune Diseases - etiology Autoimmune Diseases - prevention & control Autoimmunity (experimental aspects and models) Biological and medical sciences Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Lymphoid Tissue - radiation effects Male Rats Rats, Inbred Lew Spiro Compounds - pharmacology T-Lymphocytes, Regulatory - drug effects
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