Synthesis and antimicrobial testing of novel oxadiazolylbenzimidazole derivatives
Three novel series of oxadiazolylbenzimidazole derivatives have been prepared, namely 1-[(2-alkylthio or aralkylthio-1,3,4-oxadiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 3a-f; 1-[(3-substituted aminomethyl-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl)methyl ]-2-alkyl-1 H-benzimidazoles 4a-f and 1-[(...
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| Veröffentlicht in: | Pharmazie 1997-10, Vol.52 (10), p.746-749 |
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| container_title | Pharmazie |
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| creator | HABIB, N. S SOLIMAN, R ASHOUR, F. A EL-TAIEBI, M |
| description | Three novel series of oxadiazolylbenzimidazole derivatives have been prepared, namely 1-[(2-alkylthio or aralkylthio-1,3,4-oxadiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 3a-f; 1-[(3-substituted aminomethyl-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl)methyl ]-2-alkyl-1 H-benzimidazoles 4a-f and 1-[(2-substituted amino-1,3,4-oxidiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 6a-j. The antimicrobial testing of the prepared compounds was performed, some of them showed week activity. |
| format | Article |
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S ; SOLIMAN, R ; ASHOUR, F. A ; EL-TAIEBI, M</creator><creatorcontrib>HABIB, N. S ; SOLIMAN, R ; ASHOUR, F. A ; EL-TAIEBI, M</creatorcontrib><description>Three novel series of oxadiazolylbenzimidazole derivatives have been prepared, namely 1-[(2-alkylthio or aralkylthio-1,3,4-oxadiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 3a-f; 1-[(3-substituted aminomethyl-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl)methyl ]-2-alkyl-1 H-benzimidazoles 4a-f and 1-[(2-substituted amino-1,3,4-oxidiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 6a-j. The antimicrobial testing of the prepared compounds was performed, some of them showed week activity.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 9362087</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. 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A</creatorcontrib><creatorcontrib>EL-TAIEBI, M</creatorcontrib><title>Synthesis and antimicrobial testing of novel oxadiazolylbenzimidazole derivatives</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>Three novel series of oxadiazolylbenzimidazole derivatives have been prepared, namely 1-[(2-alkylthio or aralkylthio-1,3,4-oxadiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 3a-f; 1-[(3-substituted aminomethyl-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl)methyl ]-2-alkyl-1 H-benzimidazoles 4a-f and 1-[(2-substituted amino-1,3,4-oxidiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 6a-j. The antimicrobial testing of the prepared compounds was performed, some of them showed week activity.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Oxadiazoles - chemical synthesis</subject><subject>Oxadiazoles - pharmacology</subject><subject>Pharmacology. 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Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Oxadiazoles - chemical synthesis</topic><topic>Oxadiazoles - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HABIB, N. S</creatorcontrib><creatorcontrib>SOLIMAN, R</creatorcontrib><creatorcontrib>ASHOUR, F. A</creatorcontrib><creatorcontrib>EL-TAIEBI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HABIB, N. S</au><au>SOLIMAN, R</au><au>ASHOUR, F. 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| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Biological and medical sciences Medical sciences Microbial Sensitivity Tests Oxadiazoles - chemical synthesis Oxadiazoles - pharmacology Pharmacology. Drug treatments |
| title | Synthesis and antimicrobial testing of novel oxadiazolylbenzimidazole derivatives |
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