Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit

The kinetics of insulin-stimulated autophosphorylation of specific tyrosines in the beta subunit of the mouse insulin receptor and activation of receptor kinase-catalyzed phosphorylation of a model substrate were compared. The deduced amino acid sequence of the mouse proreceptor was determined to lo...

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Veröffentlicht in:	The Journal of biological chemistry 1989-12, Vol.264 (36), p.21557-21572
Hauptverfasser:	Flores-Riveros, J R, Sibley, E, Kastelic, T, Lane, M D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adipose Tissue - metabolism Amino Acid Sequence Animals Base Sequence Cells, Cultured DNA - genetics Humans Insulin - pharmacology Kinetics Macromolecular Substances Mice Molecular Sequence Data Phosphorylation Protein Precursors - genetics Protein Sorting Signals - genetics protein-tyrosine kinase Protein-Tyrosine Kinases - metabolism Receptor, Insulin - genetics Receptor, Insulin - metabolism Restriction Mapping Sequence Homology, Nucleic Acid Substrate Specificity
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