False-negative MR imaging of malignant breast tumors
In this study we analyze MR-negative malignant lesions of the breast. A total of 204 patients with palpable and/or mammographic lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastectomy and all spe...
Gespeichert in:
| Veröffentlicht in: | European radiology 1997-01, Vol.7 (8), p.1231-1234 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1234 |
|---|---|
| container_issue | 8 |
| container_start_page | 1231 |
| container_title | European radiology |
| container_volume | 7 |
| creator | Boetes, C Strijk, S P Holland, R Barentsz, J O Van Der Sluis, R F Ruijs, J H |
| description | In this study we analyze MR-negative malignant lesions of the breast. A total of 204 patients with palpable and/or mammographic lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastectomy and all specimens were examined by the correlative radiologic-histologic mapping technique. A total of 208 lesions were evaluated; 145 turned out to be malignant and 63 proved to be benign. Six malignant lesions were misinterpreted as benign on MR imaging; thus, suspicious contrast enhancement was present in 96 % of the lesions detected by mammography, US, or clinical examination. Especially 4 of the 17 ductal carcinoma in situ (DCIS) lesions were misinterpreted (23.5 %). Despite optimal technique, 6 malignant lesions were not identified by MR imaging. The highest prevalence of these MR occult lesions was in the group of DCIS. Although MR imaging has an important role in the evaluation of breast lesions and, primarily, in ruling out malignancy, one should be aware of the fact that false-negative MR findings do occur. |
| doi_str_mv | 10.1007/s003300050281 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79394348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2432038081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-bfc1fa78d6a9d6eef739155e55efbfa0cddfe69feceb96a1213ddb77a38978bb3</originalsourceid><addsrcrecordid>eNpd0E1LxDAQBuAgyrquHj0KxYO36KRJm-Qoi6vCiiB6LkkzKV36sSat4L-3yy6CwsBcnhlmXkIuGdwyAHkXATgHgAxSxY7InAmeUgZKHJM5aK6o1FqckrMYN5PSTMgZmWkuZQZyTsTKNBFph5UZ6i9MXt6SujVV3VVJ75PWNHXVmW5IbEATh2QY2z7Ec3Lid2MXh74gH6uH9-UTXb8-Pi_v17TkmRio9SXzRiqXG-1yRC-5ZlmGU3nrDZTOecy1xxKtzg1LGXfOSmm40lJZyxfkZr93G_rPEeNQtHUssWlMh_0YC6m5FlyoCV7_g5t-DN10W6GUyDOZyh2ie1SGPsaAvtiG6dfwXTAodlEWf6Kc_NVh6WhbdL_6kB3_AcZxbiM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884657278</pqid></control><display><type>article</type><title>False-negative MR imaging of malignant breast tumors</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Boetes, C ; Strijk, S P ; Holland, R ; Barentsz, J O ; Van Der Sluis, R F ; Ruijs, J H</creator><creatorcontrib>Boetes, C ; Strijk, S P ; Holland, R ; Barentsz, J O ; Van Der Sluis, R F ; Ruijs, J H</creatorcontrib><description>In this study we analyze MR-negative malignant lesions of the breast. A total of 204 patients with palpable and/or mammographic lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastectomy and all specimens were examined by the correlative radiologic-histologic mapping technique. A total of 208 lesions were evaluated; 145 turned out to be malignant and 63 proved to be benign. Six malignant lesions were misinterpreted as benign on MR imaging; thus, suspicious contrast enhancement was present in 96 % of the lesions detected by mammography, US, or clinical examination. Especially 4 of the 17 ductal carcinoma in situ (DCIS) lesions were misinterpreted (23.5 %). Despite optimal technique, 6 malignant lesions were not identified by MR imaging. The highest prevalence of these MR occult lesions was in the group of DCIS. Although MR imaging has an important role in the evaluation of breast lesions and, primarily, in ruling out malignancy, one should be aware of the fact that false-negative MR findings do occur.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s003300050281</identifier><identifier>PMID: 9377507</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Breast - pathology ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - epidemiology ; Carcinoma in Situ - diagnosis ; Carcinoma in Situ - epidemiology ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - epidemiology ; Carcinoma, Lobular - diagnosis ; Carcinoma, Lobular - epidemiology ; Contrast Media ; False Negative Reactions ; Female ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - statistics & numerical data ; Medical diagnosis ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity</subject><ispartof>European radiology, 1997-01, Vol.7 (8), p.1231-1234</ispartof><rights>Springer-Verlag Berlin Heidelberg 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-bfc1fa78d6a9d6eef739155e55efbfa0cddfe69feceb96a1213ddb77a38978bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9377507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boetes, C</creatorcontrib><creatorcontrib>Strijk, S P</creatorcontrib><creatorcontrib>Holland, R</creatorcontrib><creatorcontrib>Barentsz, J O</creatorcontrib><creatorcontrib>Van Der Sluis, R F</creatorcontrib><creatorcontrib>Ruijs, J H</creatorcontrib><title>False-negative MR imaging of malignant breast tumors</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>In this study we analyze MR-negative malignant lesions of the breast. A total of 204 patients with palpable and/or mammographic lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastectomy and all specimens were examined by the correlative radiologic-histologic mapping technique. A total of 208 lesions were evaluated; 145 turned out to be malignant and 63 proved to be benign. Six malignant lesions were misinterpreted as benign on MR imaging; thus, suspicious contrast enhancement was present in 96 % of the lesions detected by mammography, US, or clinical examination. Especially 4 of the 17 ductal carcinoma in situ (DCIS) lesions were misinterpreted (23.5 %). Despite optimal technique, 6 malignant lesions were not identified by MR imaging. The highest prevalence of these MR occult lesions was in the group of DCIS. Although MR imaging has an important role in the evaluation of breast lesions and, primarily, in ruling out malignancy, one should be aware of the fact that false-negative MR findings do occur.</description><subject>Breast - pathology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Carcinoma in Situ - diagnosis</subject><subject>Carcinoma in Situ - epidemiology</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - epidemiology</subject><subject>Carcinoma, Lobular - diagnosis</subject><subject>Carcinoma, Lobular - epidemiology</subject><subject>Contrast Media</subject><subject>False Negative Reactions</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0E1LxDAQBuAgyrquHj0KxYO36KRJm-Qoi6vCiiB6LkkzKV36sSat4L-3yy6CwsBcnhlmXkIuGdwyAHkXATgHgAxSxY7InAmeUgZKHJM5aK6o1FqckrMYN5PSTMgZmWkuZQZyTsTKNBFph5UZ6i9MXt6SujVV3VVJ75PWNHXVmW5IbEATh2QY2z7Ec3Lid2MXh74gH6uH9-UTXb8-Pi_v17TkmRio9SXzRiqXG-1yRC-5ZlmGU3nrDZTOecy1xxKtzg1LGXfOSmm40lJZyxfkZr93G_rPEeNQtHUssWlMh_0YC6m5FlyoCV7_g5t-DN10W6GUyDOZyh2ie1SGPsaAvtiG6dfwXTAodlEWf6Kc_NVh6WhbdL_6kB3_AcZxbiM</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Boetes, C</creator><creator>Strijk, S P</creator><creator>Holland, R</creator><creator>Barentsz, J O</creator><creator>Van Der Sluis, R F</creator><creator>Ruijs, J H</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19970101</creationdate><title>False-negative MR imaging of malignant breast tumors</title><author>Boetes, C ; Strijk, S P ; Holland, R ; Barentsz, J O ; Van Der Sluis, R F ; Ruijs, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-bfc1fa78d6a9d6eef739155e55efbfa0cddfe69feceb96a1213ddb77a38978bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Breast - pathology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Carcinoma in Situ - diagnosis</topic><topic>Carcinoma in Situ - epidemiology</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Carcinoma, Ductal, Breast - epidemiology</topic><topic>Carcinoma, Lobular - diagnosis</topic><topic>Carcinoma, Lobular - epidemiology</topic><topic>Contrast Media</topic><topic>False Negative Reactions</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boetes, C</creatorcontrib><creatorcontrib>Strijk, S P</creatorcontrib><creatorcontrib>Holland, R</creatorcontrib><creatorcontrib>Barentsz, J O</creatorcontrib><creatorcontrib>Van Der Sluis, R F</creatorcontrib><creatorcontrib>Ruijs, J H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boetes, C</au><au>Strijk, S P</au><au>Holland, R</au><au>Barentsz, J O</au><au>Van Der Sluis, R F</au><au>Ruijs, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>False-negative MR imaging of malignant breast tumors</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>7</volume><issue>8</issue><spage>1231</spage><epage>1234</epage><pages>1231-1234</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>In this study we analyze MR-negative malignant lesions of the breast. A total of 204 patients with palpable and/or mammographic lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastectomy and all specimens were examined by the correlative radiologic-histologic mapping technique. A total of 208 lesions were evaluated; 145 turned out to be malignant and 63 proved to be benign. Six malignant lesions were misinterpreted as benign on MR imaging; thus, suspicious contrast enhancement was present in 96 % of the lesions detected by mammography, US, or clinical examination. Especially 4 of the 17 ductal carcinoma in situ (DCIS) lesions were misinterpreted (23.5 %). Despite optimal technique, 6 malignant lesions were not identified by MR imaging. The highest prevalence of these MR occult lesions was in the group of DCIS. Although MR imaging has an important role in the evaluation of breast lesions and, primarily, in ruling out malignancy, one should be aware of the fact that false-negative MR findings do occur.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>9377507</pmid><doi>10.1007/s003300050281</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 1997-01, Vol.7 (8), p.1231-1234 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79394348 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Breast - pathology Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - epidemiology Carcinoma in Situ - diagnosis Carcinoma in Situ - epidemiology Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - epidemiology Carcinoma, Lobular - diagnosis Carcinoma, Lobular - epidemiology Contrast Media False Negative Reactions Female Gadolinium DTPA Humans Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - statistics & numerical data Medical diagnosis Middle Aged Retrospective Studies Sensitivity and Specificity |
| title | False-negative MR imaging of malignant breast tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T23%3A15%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=False-negative%20MR%20imaging%20of%20malignant%20breast%20tumors&rft.jtitle=European%20radiology&rft.au=Boetes,%20C&rft.date=1997-01-01&rft.volume=7&rft.issue=8&rft.spage=1231&rft.epage=1234&rft.pages=1231-1234&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s003300050281&rft_dat=%3Cproquest_cross%3E2432038081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=884657278&rft_id=info:pmid/9377507&rfr_iscdi=true |