Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro
A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities i...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 1997-07, Vol.5 (7), p.1257-1265 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Posner, Gary H. Ploypradith, Poonsakdi Hapangama, Whitney Wang, Dasong Cumming, Jared N. Dolan, Patrick Kensler, Thomas W. Klinedinst, Donna Shapiro, Theresa A. Qun Yi Zheng Murray, Christopher K. Pilkington, Lynn G. Jayasinghe, Lalith R. Bray, Jeff F. Daughenbaugh, Randy |
| description | A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
A series of tetracyclic and tricyclic trioxane dimers with ether and ester tethers of varying length and flexibility were prepared and found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro. |
| doi_str_mv | 10.1016/S0968-0896(97)00079-5 |
| format | Article |
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A series of tetracyclic and tricyclic trioxane dimers with ether and ester tethers of varying length and flexibility were prepared and found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/S0968-0896(97)00079-5</identifier><identifier>PMID: 9377085</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antimalarials - chemical synthesis ; Antimalarials - pharmacology ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Cell Division - drug effects ; Dimerization ; Drug Screening Assays, Antitumor ; Heterocyclic Compounds - chemical synthesis ; Heterocyclic Compounds - pharmacology ; Humans ; Tumor Cells, Cultured</subject><ispartof>Bioorganic & medicinal chemistry, 1997-07, Vol.5 (7), p.1257-1265</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-3667b79b743e416019631a7b13f49310855efd8b63942fd6126448fe35d9acf73</citedby><cites>FETCH-LOGICAL-c407t-3667b79b743e416019631a7b13f49310855efd8b63942fd6126448fe35d9acf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089697000795$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9377085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Posner, Gary H.</creatorcontrib><creatorcontrib>Ploypradith, Poonsakdi</creatorcontrib><creatorcontrib>Hapangama, Whitney</creatorcontrib><creatorcontrib>Wang, Dasong</creatorcontrib><creatorcontrib>Cumming, Jared N.</creatorcontrib><creatorcontrib>Dolan, Patrick</creatorcontrib><creatorcontrib>Kensler, Thomas W.</creatorcontrib><creatorcontrib>Klinedinst, Donna</creatorcontrib><creatorcontrib>Shapiro, Theresa A.</creatorcontrib><creatorcontrib>Qun Yi Zheng</creatorcontrib><creatorcontrib>Murray, Christopher K.</creatorcontrib><creatorcontrib>Pilkington, Lynn G.</creatorcontrib><creatorcontrib>Jayasinghe, Lalith R.</creatorcontrib><creatorcontrib>Bray, Jeff F.</creatorcontrib><creatorcontrib>Daughenbaugh, Randy</creatorcontrib><title>Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
A series of tetracyclic and tricyclic trioxane dimers with ether and ester tethers of varying length and flexibility were prepared and found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.</description><subject>Antimalarials - chemical synthesis</subject><subject>Antimalarials - pharmacology</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Dimerization</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Heterocyclic Compounds - chemical synthesis</subject><subject>Heterocyclic Compounds - pharmacology</subject><subject>Humans</subject><subject>Tumor Cells, Cultured</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6ExZ6EgWrSZMmzUlk8QsWPLgeJaTtFCNtsybpov_ebHfx6mkyM-9k5n0QmhN8TTDhN69Y8iLFheQXUlxijIVM8wM0JYyzlFJJDtH0T3KMTrz_jKKMSTJBE0mFwEU-Re8rZ-y37iGpTQfOJx96A8naBuhDovtgOt1qZ3R7NWZrZ1vTgNPBRJnu67Eahs66RFexaIIBn5g-iS9nT9FRo1sPZ_s4Q28P96vFU7p8eXxe3C3TimERUsq5KIUsBaPACMdEckq0KAltmKQkHppDUxclp5JlTc1JxhkrGqB5LXXVCDpD57t_431fA_igOuMraNtozA5eCUllVmQ0CvOdsHLWeweNWrto0f0ogtUWqxqxqi0zJYUasao8zs33C4ayg_pvas8x9m93fYguNwac8pWBvoLaOKiCqq35Z8MvoDiIVw</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Posner, Gary H.</creator><creator>Ploypradith, Poonsakdi</creator><creator>Hapangama, Whitney</creator><creator>Wang, Dasong</creator><creator>Cumming, Jared N.</creator><creator>Dolan, Patrick</creator><creator>Kensler, Thomas W.</creator><creator>Klinedinst, Donna</creator><creator>Shapiro, Theresa A.</creator><creator>Qun Yi Zheng</creator><creator>Murray, Christopher K.</creator><creator>Pilkington, Lynn G.</creator><creator>Jayasinghe, Lalith R.</creator><creator>Bray, Jeff F.</creator><creator>Daughenbaugh, Randy</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro</title><author>Posner, Gary H. ; Ploypradith, Poonsakdi ; Hapangama, Whitney ; Wang, Dasong ; Cumming, Jared N. ; Dolan, Patrick ; Kensler, Thomas W. ; Klinedinst, Donna ; Shapiro, Theresa A. ; Qun Yi Zheng ; Murray, Christopher K. ; Pilkington, Lynn G. ; Jayasinghe, Lalith R. ; Bray, Jeff F. ; Daughenbaugh, Randy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-3667b79b743e416019631a7b13f49310855efd8b63942fd6126448fe35d9acf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antimalarials - chemical synthesis</topic><topic>Antimalarials - pharmacology</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Dimerization</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Heterocyclic Compounds - chemical synthesis</topic><topic>Heterocyclic Compounds - pharmacology</topic><topic>Humans</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Posner, Gary H.</creatorcontrib><creatorcontrib>Ploypradith, Poonsakdi</creatorcontrib><creatorcontrib>Hapangama, Whitney</creatorcontrib><creatorcontrib>Wang, Dasong</creatorcontrib><creatorcontrib>Cumming, Jared N.</creatorcontrib><creatorcontrib>Dolan, Patrick</creatorcontrib><creatorcontrib>Kensler, Thomas W.</creatorcontrib><creatorcontrib>Klinedinst, Donna</creatorcontrib><creatorcontrib>Shapiro, Theresa A.</creatorcontrib><creatorcontrib>Qun Yi Zheng</creatorcontrib><creatorcontrib>Murray, Christopher K.</creatorcontrib><creatorcontrib>Pilkington, Lynn G.</creatorcontrib><creatorcontrib>Jayasinghe, Lalith R.</creatorcontrib><creatorcontrib>Bray, Jeff F.</creatorcontrib><creatorcontrib>Daughenbaugh, Randy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Posner, Gary H.</au><au>Ploypradith, Poonsakdi</au><au>Hapangama, Whitney</au><au>Wang, Dasong</au><au>Cumming, Jared N.</au><au>Dolan, Patrick</au><au>Kensler, Thomas W.</au><au>Klinedinst, Donna</au><au>Shapiro, Theresa A.</au><au>Qun Yi Zheng</au><au>Murray, Christopher K.</au><au>Pilkington, Lynn G.</au><au>Jayasinghe, Lalith R.</au><au>Bray, Jeff F.</au><au>Daughenbaugh, Randy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>5</volume><issue>7</issue><spage>1257</spage><epage>1265</epage><pages>1257-1265</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
A series of tetracyclic and tricyclic trioxane dimers with ether and ester tethers of varying length and flexibility were prepared and found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>9377085</pmid><doi>10.1016/S0968-0896(97)00079-5</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry, 1997-07, Vol.5 (7), p.1257-1265 |
| issn | 0968-0896 1464-3391 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antimalarials - chemical synthesis Antimalarials - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Cell Division - drug effects Dimerization Drug Screening Assays, Antitumor Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - pharmacology Humans Tumor Cells, Cultured |
| title | Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro |
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