The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog

To determine the relationship between topotecan and its ring opened hydrolysis product (SK&F 105,992) following intravenous administration of the two agents separately, and to determine the bio-availability of topotecan in female beagle dogs. The pharmacokinetics of topotecan and SK&F 105,99...

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Veröffentlicht in:	Pharmaceutical research 1997-10, Vol.14 (10), p.1461-1465
Hauptverfasser:	DAVIES, B. E, MINTHORN, E. A, DENNIS, M. J, ROSING, H, BEIJNEN, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic agents Biological and medical sciences Biological Availability Biotransformation Chemotherapy Dogs Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - blood Enzyme Inhibitors - pharmacokinetics Female Injections, Intravenous Medical sciences Pharmacology. Drug treatments Topoisomerase I Inhibitors Topotecan - administration & dosage Topotecan - blood Topotecan - pharmacokinetics
Online-Zugang:	Volltext
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