Atrial Natriuretic Peptide Lowers Pulmonary Arterial Pressure in Patients with High Altitude Disease
The authors’ previous studies have demonstrated that IV administration of atrial natriuretic peptide (ANP) produces a dose dependent decrease in pulmonary arterial pressure in rats adapted to chronic hypoxia. To examine the effects of ANP on chronic hypoxic pulmonary hypertension in man, α-human ANP...
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| Veröffentlicht in: | The American journal of the medical sciences 1989-12, Vol.298 (6), p.397-401 |
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| container_end_page | 401 |
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| container_issue | 6 |
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| container_title | The American journal of the medical sciences |
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| creator | Liu, Lisheng Cheng, Huayang Chin, Weijuan Jin, Hongkui Oparil, Suzanne |
| description | The authors’ previous studies have demonstrated that IV administration of atrial natriuretic peptide (ANP) produces a dose dependent decrease in pulmonary arterial pressure in rats adapted to chronic hypoxia. To examine the effects of ANP on chronic hypoxic pulmonary hypertension in man, α-human ANP (200 µg) was infused (20 µg/min ×10 min) into the right atrium via a Swan-Ganz catheter in four patients with pulmonary hypertension of high altitude. Following the infusion, pulmonary arterial pressure fell gradually and remained depressed for 1 hour. Peak reductions in pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were 23% and 30%, respectively. Systemic arterial pressure, cardiac output and cardiac index also tended to decrease, but these changes did not reach statistical significance. The data suggest that ANP is useful in the treatment of chronic hypoxic pulmonary hypertension in man. |
| doi_str_mv | 10.1097/00000441-198912000-00007 |
| format | Article |
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To examine the effects of ANP on chronic hypoxic pulmonary hypertension in man, α-human ANP (200 µg) was infused (20 µg/min ×10 min) into the right atrium via a Swan-Ganz catheter in four patients with pulmonary hypertension of high altitude. Following the infusion, pulmonary arterial pressure fell gradually and remained depressed for 1 hour. Peak reductions in pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were 23% and 30%, respectively. Systemic arterial pressure, cardiac output and cardiac index also tended to decrease, but these changes did not reach statistical significance. The data suggest that ANP is useful in the treatment of chronic hypoxic pulmonary hypertension in man.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198912000-00007</identifier><identifier>PMID: 2531977</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Aldosterone - blood ; Altitude Sickness - drug therapy ; Atrial Natriuretic Factor - therapeutic use ; Atrial Natriuretic Peptide ; Biological and medical sciences ; Chronic Hypoxia ; High Altitude ; Hypertension, Pulmonary - drug therapy ; Hypoxia - drug therapy ; Medical sciences ; Pneumology ; Pulmonary Arterial Pressure ; Pulmonary Hypertension ; Renin - blood ; Respiratory system : syndromes and miscellaneous diseases ; Space life sciences</subject><ispartof>The American journal of the medical sciences, 1989-12, Vol.298 (6), p.397-401</ispartof><rights>1989 Southern Society for Clinical Investigation</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-51e07c69e880c512fa27ffaccf2a588dab710a1aa96b04c49811277024a788183</citedby><cites>FETCH-LOGICAL-c399t-51e07c69e880c512fa27ffaccf2a588dab710a1aa96b04c49811277024a788183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19660317$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2531977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Lisheng</creatorcontrib><creatorcontrib>Cheng, Huayang</creatorcontrib><creatorcontrib>Chin, Weijuan</creatorcontrib><creatorcontrib>Jin, Hongkui</creatorcontrib><creatorcontrib>Oparil, Suzanne</creatorcontrib><title>Atrial Natriuretic Peptide Lowers Pulmonary Arterial Pressure in Patients with High Altitude Disease</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>The authors’ previous studies have demonstrated that IV administration of atrial natriuretic peptide (ANP) produces a dose dependent decrease in pulmonary arterial pressure in rats adapted to chronic hypoxia. To examine the effects of ANP on chronic hypoxic pulmonary hypertension in man, α-human ANP (200 µg) was infused (20 µg/min ×10 min) into the right atrium via a Swan-Ganz catheter in four patients with pulmonary hypertension of high altitude. Following the infusion, pulmonary arterial pressure fell gradually and remained depressed for 1 hour. Peak reductions in pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were 23% and 30%, respectively. Systemic arterial pressure, cardiac output and cardiac index also tended to decrease, but these changes did not reach statistical significance. The data suggest that ANP is useful in the treatment of chronic hypoxic pulmonary hypertension in man.</description><subject>Aldosterone - blood</subject><subject>Altitude Sickness - drug therapy</subject><subject>Atrial Natriuretic Factor - therapeutic use</subject><subject>Atrial Natriuretic Peptide</subject><subject>Biological and medical sciences</subject><subject>Chronic Hypoxia</subject><subject>High Altitude</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>Hypoxia - drug therapy</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Pulmonary Arterial Pressure</subject><subject>Pulmonary Hypertension</subject><subject>Renin - blood</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Space life sciences</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9vEzEQxS0EKqHwEZB8gduCx_vH9jG0QJEiyAHO1sQ7S402u8HjpeLb4zShHPFl5Ddv3tg_ISSoN6CceauOp2mgAmcd6HKpjop5JFbQ1rbSzqnHYlUkXblOu6fiGfMPpUBbqC_EhW5rcMasRL_OKeIoP2OpS6Icg9zSIcee5Ga-o8Ryu4z7ecL0W65Tpnv3NhFzccs4yS3mSFNmeRfzrbyJ32_leswxLyXhOjIh03PxZMCR6cW5XopvH95_vbqpNl8-frpab6pQO5erFkiZ0DmyVoUW9IDaDAOGMGhsre1xZ0AhILpup5rQOAugjVG6QWMt2PpSvD7lHtL8cyHOfh850DjiRPPC3rjaKaOgGO3JGNLMnGjwhxT35YselD8C9n8B-wfA95Ipoy_PO5bdnvqHwTPR0n917iMHHIeEU4j8L991narh6Ht38lEB8itS8hwKx0B9TBSy7-f4_8f8Ab47l2I</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Liu, Lisheng</creator><creator>Cheng, Huayang</creator><creator>Chin, Weijuan</creator><creator>Jin, Hongkui</creator><creator>Oparil, Suzanne</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891201</creationdate><title>Atrial Natriuretic Peptide Lowers Pulmonary Arterial Pressure in Patients with High Altitude Disease</title><author>Liu, Lisheng ; Cheng, Huayang ; Chin, Weijuan ; Jin, Hongkui ; Oparil, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-51e07c69e880c512fa27ffaccf2a588dab710a1aa96b04c49811277024a788183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aldosterone - blood</topic><topic>Altitude Sickness - drug therapy</topic><topic>Atrial Natriuretic Factor - therapeutic use</topic><topic>Atrial Natriuretic Peptide</topic><topic>Biological and medical sciences</topic><topic>Chronic Hypoxia</topic><topic>High Altitude</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>Hypoxia - drug therapy</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Pulmonary Arterial Pressure</topic><topic>Pulmonary Hypertension</topic><topic>Renin - blood</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lisheng</creatorcontrib><creatorcontrib>Cheng, Huayang</creatorcontrib><creatorcontrib>Chin, Weijuan</creatorcontrib><creatorcontrib>Jin, Hongkui</creatorcontrib><creatorcontrib>Oparil, Suzanne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lisheng</au><au>Cheng, Huayang</au><au>Chin, Weijuan</au><au>Jin, Hongkui</au><au>Oparil, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial Natriuretic Peptide Lowers Pulmonary Arterial Pressure in Patients with High Altitude Disease</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>298</volume><issue>6</issue><spage>397</spage><epage>401</epage><pages>397-401</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>The authors’ previous studies have demonstrated that IV administration of atrial natriuretic peptide (ANP) produces a dose dependent decrease in pulmonary arterial pressure in rats adapted to chronic hypoxia. To examine the effects of ANP on chronic hypoxic pulmonary hypertension in man, α-human ANP (200 µg) was infused (20 µg/min ×10 min) into the right atrium via a Swan-Ganz catheter in four patients with pulmonary hypertension of high altitude. Following the infusion, pulmonary arterial pressure fell gradually and remained depressed for 1 hour. Peak reductions in pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were 23% and 30%, respectively. Systemic arterial pressure, cardiac output and cardiac index also tended to decrease, but these changes did not reach statistical significance. The data suggest that ANP is useful in the treatment of chronic hypoxic pulmonary hypertension in man.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>2531977</pmid><doi>10.1097/00000441-198912000-00007</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of the medical sciences, 1989-12, Vol.298 (6), p.397-401 |
| issn | 0002-9629 1538-2990 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aldosterone - blood Altitude Sickness - drug therapy Atrial Natriuretic Factor - therapeutic use Atrial Natriuretic Peptide Biological and medical sciences Chronic Hypoxia High Altitude Hypertension, Pulmonary - drug therapy Hypoxia - drug therapy Medical sciences Pneumology Pulmonary Arterial Pressure Pulmonary Hypertension Renin - blood Respiratory system : syndromes and miscellaneous diseases Space life sciences |
| title | Atrial Natriuretic Peptide Lowers Pulmonary Arterial Pressure in Patients with High Altitude Disease |
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